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Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients.
Curr Drug Metab 2006; 7(6):599-612CD

Abstract

Insufficient immunosurveillance is an important aspect in early tumorigenesis and in the pathogenesis of malignant disease. In the later course of cancer, the development of immunodeficiency is considered the major reason for disease progression and death. Within the anti-tumoral host defense reaction, Th1-type cytokine interferon-gamma (IFN-gamma) is of particular relevance. IFN-gamma stimulates several anti-proliferative and thus tumoricidal biochemical pathways in macrophages and other cells and also in tumor cell lines. These include inducible nitric oxide synthase, indoleamine (2, 3)-dioxygenase, an enzyme degrading the essential amino acid tryptophan, and the production of reactive oxygen species and neopterin in human macrophages and dendritic cells. Although the anti-proliferative strategy of the immune system aims to inhibit the growth of malignant cells, it can also affect T-cell response and thus contribute to the development of immunodeficiency. Accelerated degradation of tryptophan and increased production of neopterin were found to parallel the course of malignant diseases. Moreover, a higher degree of these metabolic changes characterizes poor prognosis and is associated with the development of anemia, weight loss and depressive mood in patients. Available data suggest that immunodeficiency in cancer patients may develop as a long-term side-effect of the antiproliferative and pro-apoptotic mechanisms elicited within Th1-type immune response, and enhanced production of pro-inflammatory cytokine IFN-gamma seems to be critically involved.

Authors+Show Affiliations

Department of General and Transplant Surgery, Tyrolean Cancer Research Institute, Innsbruck Medical University, Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16918315

Citation

Brandacher, Gerald, et al. "Antitumoral Activity of Interferon-gamma Involved in Impaired Immune Function in Cancer Patients." Current Drug Metabolism, vol. 7, no. 6, 2006, pp. 599-612.
Brandacher G, Winkler C, Schroecksnadel K, et al. Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients. Curr Drug Metab. 2006;7(6):599-612.
Brandacher, G., Winkler, C., Schroecksnadel, K., Margreiter, R., & Fuchs, D. (2006). Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients. Current Drug Metabolism, 7(6), pp. 599-612.
Brandacher G, et al. Antitumoral Activity of Interferon-gamma Involved in Impaired Immune Function in Cancer Patients. Curr Drug Metab. 2006;7(6):599-612. PubMed PMID: 16918315.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients. AU - Brandacher,Gerald, AU - Winkler,Christiana, AU - Schroecksnadel,Katharina, AU - Margreiter,Raimund, AU - Fuchs,Dietmar, PY - 2006/8/22/pubmed PY - 2006/9/15/medline PY - 2006/8/22/entrez SP - 599 EP - 612 JF - Current drug metabolism JO - Curr. Drug Metab. VL - 7 IS - 6 N2 - Insufficient immunosurveillance is an important aspect in early tumorigenesis and in the pathogenesis of malignant disease. In the later course of cancer, the development of immunodeficiency is considered the major reason for disease progression and death. Within the anti-tumoral host defense reaction, Th1-type cytokine interferon-gamma (IFN-gamma) is of particular relevance. IFN-gamma stimulates several anti-proliferative and thus tumoricidal biochemical pathways in macrophages and other cells and also in tumor cell lines. These include inducible nitric oxide synthase, indoleamine (2, 3)-dioxygenase, an enzyme degrading the essential amino acid tryptophan, and the production of reactive oxygen species and neopterin in human macrophages and dendritic cells. Although the anti-proliferative strategy of the immune system aims to inhibit the growth of malignant cells, it can also affect T-cell response and thus contribute to the development of immunodeficiency. Accelerated degradation of tryptophan and increased production of neopterin were found to parallel the course of malignant diseases. Moreover, a higher degree of these metabolic changes characterizes poor prognosis and is associated with the development of anemia, weight loss and depressive mood in patients. Available data suggest that immunodeficiency in cancer patients may develop as a long-term side-effect of the antiproliferative and pro-apoptotic mechanisms elicited within Th1-type immune response, and enhanced production of pro-inflammatory cytokine IFN-gamma seems to be critically involved. SN - 1389-2002 UR - https://www.unboundmedicine.com/medline/citation/16918315/Antitumoral_activity_of_interferon_gamma_involved_in_impaired_immune_function_in_cancer_patients_ L2 - http://www.eurekaselect.com/56422/article DB - PRIME DP - Unbound Medicine ER -