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Protamine and mast-cell-mediated angiogenesis in the rat.
J Exp Pathol (Oxford). 1990 Apr; 71(2):209-17.JE

Abstract

Different doses of protamine sulphate (PS) given s.c. (at 12-h intervals) were tested for signs of non-specific toxicity measured as effect on body weight and small-gut proliferation as well as on mast-cell secretion and mast-cell-mediated mitogenesis in the mesenteric windows following i.p. injection of Compound 48/80, a potent mast cell secretagogue, in normal rats. In a non-toxic dose range, the effect of PS on mast-cell-mediated angiogenesis, effected by 48/80, was quantified as the number of vessels per mm of mesenteric window in histological sections at x 400. No intelligible dose-effect relationship was discernible between the dose of PS given and the effect on angiogenesis. Only in a tight interval, at 40 mg PS/kg but not at 20 or 60 mg PS/kg, was the angiogenesis statistically significantly suppressed. Hence, it was concluded that PS can be angiostatic but does not exert a more general angiostatic effect in the autogenous systems used.

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Authors+Show Affiliations

Jakobsson A
Department of Pathology, Gothenburg University, Sahlgren's Hospital, Sweden.
Sörbo J
No affiliation info available
Norrby K
No affiliation info available

MeSH

AnimalsMaleMast CellsMesenteric ArteriesMesenteric VeinsNeovascularization, PathologicProtaminesRatsRats, Inbred Strainsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1691920

Citation

Jakobsson, A, et al. "Protamine and Mast-cell-mediated Angiogenesis in the Rat." Journal of Experimental Pathology (Oxford, England), vol. 71, no. 2, 1990, pp. 209-17.
Jakobsson A, Sörbo J, Norrby K. Protamine and mast-cell-mediated angiogenesis in the rat. J Exp Pathol (Oxford). 1990;71(2):209-17.
Jakobsson, A., Sörbo, J., & Norrby, K. (1990). Protamine and mast-cell-mediated angiogenesis in the rat. Journal of Experimental Pathology (Oxford, England), 71(2), 209-17.
Jakobsson A, Sörbo J, Norrby K. Protamine and Mast-cell-mediated Angiogenesis in the Rat. J Exp Pathol (Oxford). 1990;71(2):209-17. PubMed PMID: 1691920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protamine and mast-cell-mediated angiogenesis in the rat. AU - Jakobsson,A, AU - Sörbo,J, AU - Norrby,K, PY - 1990/4/1/pubmed PY - 1990/4/1/medline PY - 1990/4/1/entrez SP - 209 EP - 17 JF - Journal of experimental pathology (Oxford, England) JO - J Exp Pathol (Oxford) VL - 71 IS - 2 N2 - Different doses of protamine sulphate (PS) given s.c. (at 12-h intervals) were tested for signs of non-specific toxicity measured as effect on body weight and small-gut proliferation as well as on mast-cell secretion and mast-cell-mediated mitogenesis in the mesenteric windows following i.p. injection of Compound 48/80, a potent mast cell secretagogue, in normal rats. In a non-toxic dose range, the effect of PS on mast-cell-mediated angiogenesis, effected by 48/80, was quantified as the number of vessels per mm of mesenteric window in histological sections at x 400. No intelligible dose-effect relationship was discernible between the dose of PS given and the effect on angiogenesis. Only in a tight interval, at 40 mg PS/kg but not at 20 or 60 mg PS/kg, was the angiogenesis statistically significantly suppressed. Hence, it was concluded that PS can be angiostatic but does not exert a more general angiostatic effect in the autogenous systems used. SN - 0958-4625 UR - https://www.unboundmedicine.com/medline/citation/1691920/Protamine_and_mast_cell_mediated_angiogenesis_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -