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Effect of atrial fibrillation on plasma NT-proBNP in chronic heart failure.
Int J Cardiol. 2007 May 02; 117(3):395-402.IJ

Abstract

BACKGROUND

Brain natriuretic peptides are elevated in patients with systolic heart failure (HF) as well as in patients with atrial fibrillation (AF) and normal left ventricular ejection fraction (LVEF) and are strong predictors of death in HF patients. The aim of our study was to examine the levels of N-terminal pro brain natriuretic peptide (NT-proBNP) in patients with HF and AF versus HF and sinus rhythm (SR) and if NT-proBNP has prognostic influence in patients with AF.

METHODS

We included 245 patients (72% men, 70 years) with HF referred to a HF clinic. NT-proBNP was measured at referral (baseline).

RESULTS

At baseline, 26% had AF and at follow-up 35% of the surviving patients. Patients with AF were older than patients with SR (p=0.009), but LVEF and NYHA distribution were similar. Median NT-proBNP levels were higher: 2528 vs. 899 pg/ml (p<0.001). NT-proBNP was significantly correlated with AF at baseline (p<0.001), age (p=0.001), P-creatinine (p<0.001) and reduced LVEF (p=0.002). NT-proBNP was an independent predictor of death in patients with AF, adjusted HR 4.0 (95% CI 1.6-10.2) (p=0.003).

CONCLUSION

NT-proBNP levels are higher in HF patients with AF than in HF patients with SR and has prognostic value despite the presence of AF.

Authors+Show Affiliations

Department of Cardiology and Endocrinology E, Frederiksberg University Hospital, Ndr. Fasanvej 57, 2000 Frederiksberg, Denmark. pernillecorell@dadlnet.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16919342

Citation

Corell, Pernille, et al. "Effect of Atrial Fibrillation On Plasma NT-proBNP in Chronic Heart Failure." International Journal of Cardiology, vol. 117, no. 3, 2007, pp. 395-402.
Corell P, Gustafsson F, Kistorp C, et al. Effect of atrial fibrillation on plasma NT-proBNP in chronic heart failure. Int J Cardiol. 2007;117(3):395-402.
Corell, P., Gustafsson, F., Kistorp, C., Madsen, L. H., Schou, M., & Hildebrandt, P. (2007). Effect of atrial fibrillation on plasma NT-proBNP in chronic heart failure. International Journal of Cardiology, 117(3), 395-402.
Corell P, et al. Effect of Atrial Fibrillation On Plasma NT-proBNP in Chronic Heart Failure. Int J Cardiol. 2007 May 2;117(3):395-402. PubMed PMID: 16919342.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of atrial fibrillation on plasma NT-proBNP in chronic heart failure. AU - Corell,Pernille, AU - Gustafsson,Finn, AU - Kistorp,Caroline, AU - Madsen,Lene Helleskov, AU - Schou,Morten, AU - Hildebrandt,Per, Y1 - 2006/08/17/ PY - 2005/08/29/received PY - 2006/03/02/revised PY - 2006/03/04/accepted PY - 2006/8/22/pubmed PY - 2007/7/10/medline PY - 2006/8/22/entrez SP - 395 EP - 402 JF - International journal of cardiology JO - Int J Cardiol VL - 117 IS - 3 N2 - BACKGROUND: Brain natriuretic peptides are elevated in patients with systolic heart failure (HF) as well as in patients with atrial fibrillation (AF) and normal left ventricular ejection fraction (LVEF) and are strong predictors of death in HF patients. The aim of our study was to examine the levels of N-terminal pro brain natriuretic peptide (NT-proBNP) in patients with HF and AF versus HF and sinus rhythm (SR) and if NT-proBNP has prognostic influence in patients with AF. METHODS: We included 245 patients (72% men, 70 years) with HF referred to a HF clinic. NT-proBNP was measured at referral (baseline). RESULTS: At baseline, 26% had AF and at follow-up 35% of the surviving patients. Patients with AF were older than patients with SR (p=0.009), but LVEF and NYHA distribution were similar. Median NT-proBNP levels were higher: 2528 vs. 899 pg/ml (p<0.001). NT-proBNP was significantly correlated with AF at baseline (p<0.001), age (p=0.001), P-creatinine (p<0.001) and reduced LVEF (p=0.002). NT-proBNP was an independent predictor of death in patients with AF, adjusted HR 4.0 (95% CI 1.6-10.2) (p=0.003). CONCLUSION: NT-proBNP levels are higher in HF patients with AF than in HF patients with SR and has prognostic value despite the presence of AF. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/16919342/Effect_of_atrial_fibrillation_on_plasma_NT_proBNP_in_chronic_heart_failure_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(06)00600-0 DB - PRIME DP - Unbound Medicine ER -