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Antiarrhythmic effects of omega-3 fatty acids.
Am J Cardiol. 2006 Aug 21; 98(4A):50i-60i.AJ

Abstract

Fish oil, and omega-3 fatty acids in particular, have been found to reduce plasma levels of triglycerides and increase levels of high-density lipoprotein in patients with marked hypertriglyceridemia, and a pharmaceutical-grade preparation has recently received approval from the US Food and Drug Administration to market for this purpose. However, in both bench research studies and clinical trials, evidence for clinically significant antiarrhythmic properties has also been detected in association with omega-3 fatty acid intake. Arguably the most significant finding in this data set was the reduction in the incidence of sudden death in survivors of myocardial infarction in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione trial and the subsequent recommendation for administration of fish oil as part of the postinfarction regimen in Europe. This article reviews in detail the basic and clinical research studies of fish oil as an antiarrhythmic entity, the forms of preparation and/or administration that appear to possess these properties and those that do not, the types of arrhythmias (ventricular ectopy and atrial fibrillation as well as ventricular tachyarrhythmias) that have been beneficially affected by fish oil administration, and the presumed and known mechanisms by which the beneficial actions are exerted.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University Medical Center, New York, New York 10032, USA. jar2@columbia.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16919517

Citation

Reiffel, James A., and Arline McDonald. "Antiarrhythmic Effects of Omega-3 Fatty Acids." The American Journal of Cardiology, vol. 98, no. 4A, 2006, pp. 50i-60i.
Reiffel JA, McDonald A. Antiarrhythmic effects of omega-3 fatty acids. Am J Cardiol. 2006;98(4A):50i-60i.
Reiffel, J. A., & McDonald, A. (2006). Antiarrhythmic effects of omega-3 fatty acids. The American Journal of Cardiology, 98(4A), 50i-60i.
Reiffel JA, McDonald A. Antiarrhythmic Effects of Omega-3 Fatty Acids. Am J Cardiol. 2006 Aug 21;98(4A):50i-60i. PubMed PMID: 16919517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiarrhythmic effects of omega-3 fatty acids. AU - Reiffel,James A, AU - McDonald,Arline, Y1 - 2006/05/26/ PY - 2006/8/22/pubmed PY - 2006/9/29/medline PY - 2006/8/22/entrez SP - 50i EP - 60i JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 98 IS - 4A N2 - Fish oil, and omega-3 fatty acids in particular, have been found to reduce plasma levels of triglycerides and increase levels of high-density lipoprotein in patients with marked hypertriglyceridemia, and a pharmaceutical-grade preparation has recently received approval from the US Food and Drug Administration to market for this purpose. However, in both bench research studies and clinical trials, evidence for clinically significant antiarrhythmic properties has also been detected in association with omega-3 fatty acid intake. Arguably the most significant finding in this data set was the reduction in the incidence of sudden death in survivors of myocardial infarction in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione trial and the subsequent recommendation for administration of fish oil as part of the postinfarction regimen in Europe. This article reviews in detail the basic and clinical research studies of fish oil as an antiarrhythmic entity, the forms of preparation and/or administration that appear to possess these properties and those that do not, the types of arrhythmias (ventricular ectopy and atrial fibrillation as well as ventricular tachyarrhythmias) that have been beneficially affected by fish oil administration, and the presumed and known mechanisms by which the beneficial actions are exerted. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/16919517/Antiarrhythmic_effects_of_omega_3_fatty_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(05)02190-9 DB - PRIME DP - Unbound Medicine ER -