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Compromised autoregulatory control of ocular hemodynamics in glaucoma patients after postural change.
Ophthalmology. 2006 Oct; 113(10):1832-6.O

Abstract

PURPOSE

The autoregulatory control of retrobulbar blood flow in response to postural challenge was investigated in normal-tension glaucoma (NTG) patients in comparison with primary open-angle glaucoma (POAG) patients and healthy volunteers.

DESIGN

Prospective cohort study.

PARTICIPANTS AND CONTROLS

Twenty POAG patients, 20 NTG patients, and 20 control subjects.

METHODS

Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistivity index (RI) in the short posterior ciliary artery (SPCA), central retinal artery (CRA) and ophthalmic artery (OA) were recorded after a change from sitting upright to a supine body position using color Doppler imaging.

MAIN OUTCOME MEASURES

Peak systolic velocity, EDV, and RI.

RESULTS

Ten minutes after postural change to a supine position, blood flow velocities in the SPCA remained unchanged in controls, whereas a significant increase of PSV and EDV was found in both glaucoma groups. The RI in the SPCA was significantly lowered in the NTG group. Recordings for the OA and CRA showed a significant increase in EDV and significant decrease in RI in all 3 groups; a significant increase in PSV in the CRA was detected only in the NTG group.

CONCLUSIONS

The unaltered flow velocities in the SPCA of healthy controls may indicate tight autoregulatory control, whereas the flow velocities in the CRA and OA appeared to follow alterations in hydrostatic pressure. In contrast, NTG and POAG patients demonstrated an insufficient compensatory response to postural change, leading to accelerated flow in the SPCA. This compromised autoregulatory control could represent another contributing factor in the pathogenesis of glaucoma.

Authors+Show Affiliations

Glaukomlabor, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16920194

Citation

Galambos, Peter, et al. "Compromised Autoregulatory Control of Ocular Hemodynamics in Glaucoma Patients After Postural Change." Ophthalmology, vol. 113, no. 10, 2006, pp. 1832-6.
Galambos P, Vafiadis J, Vilchez SE, et al. Compromised autoregulatory control of ocular hemodynamics in glaucoma patients after postural change. Ophthalmology. 2006;113(10):1832-6.
Galambos, P., Vafiadis, J., Vilchez, S. E., Wagenfeld, L., Matthiessen, E. T., Richard, G., Klemm, M., & Zeitz, O. (2006). Compromised autoregulatory control of ocular hemodynamics in glaucoma patients after postural change. Ophthalmology, 113(10), 1832-6.
Galambos P, et al. Compromised Autoregulatory Control of Ocular Hemodynamics in Glaucoma Patients After Postural Change. Ophthalmology. 2006;113(10):1832-6. PubMed PMID: 16920194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Compromised autoregulatory control of ocular hemodynamics in glaucoma patients after postural change. AU - Galambos,Peter, AU - Vafiadis,Joanna, AU - Vilchez,Silvia E, AU - Wagenfeld,Lars, AU - Matthiessen,Eike T, AU - Richard,Gisbert, AU - Klemm,Maren, AU - Zeitz,Oliver, Y1 - 2006/08/22/ PY - 2005/06/24/received PY - 2006/05/23/revised PY - 2006/05/26/accepted PY - 2006/8/22/pubmed PY - 2006/10/14/medline PY - 2006/8/22/entrez SP - 1832 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 10 N2 - PURPOSE: The autoregulatory control of retrobulbar blood flow in response to postural challenge was investigated in normal-tension glaucoma (NTG) patients in comparison with primary open-angle glaucoma (POAG) patients and healthy volunteers. DESIGN: Prospective cohort study. PARTICIPANTS AND CONTROLS: Twenty POAG patients, 20 NTG patients, and 20 control subjects. METHODS: Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistivity index (RI) in the short posterior ciliary artery (SPCA), central retinal artery (CRA) and ophthalmic artery (OA) were recorded after a change from sitting upright to a supine body position using color Doppler imaging. MAIN OUTCOME MEASURES: Peak systolic velocity, EDV, and RI. RESULTS: Ten minutes after postural change to a supine position, blood flow velocities in the SPCA remained unchanged in controls, whereas a significant increase of PSV and EDV was found in both glaucoma groups. The RI in the SPCA was significantly lowered in the NTG group. Recordings for the OA and CRA showed a significant increase in EDV and significant decrease in RI in all 3 groups; a significant increase in PSV in the CRA was detected only in the NTG group. CONCLUSIONS: The unaltered flow velocities in the SPCA of healthy controls may indicate tight autoregulatory control, whereas the flow velocities in the CRA and OA appeared to follow alterations in hydrostatic pressure. In contrast, NTG and POAG patients demonstrated an insufficient compensatory response to postural change, leading to accelerated flow in the SPCA. This compromised autoregulatory control could represent another contributing factor in the pathogenesis of glaucoma. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16920194/Compromised_autoregulatory_control_of_ocular_hemodynamics_in_glaucoma_patients_after_postural_change_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00716-0 DB - PRIME DP - Unbound Medicine ER -