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Effect of the C-terminus of murine S100A9 protein on experimental nociception.
Peptides. 2006 Nov; 27(11):2794-802.P

Abstract

Calcium-binding protein S100A9 induces antinociception in mice evaluated by the writhing test. Similarly, a peptide identical to the C-terminus of murine S100A9 (mS100A9p) inhibits the hyperalgesia induced by jararhagin, a metalloprotease. Thus, we investigated the effect of mS100A9p on different models used to evaluate nociception. mS100A9p induced a dose-dependent inhibitory effect on the writhing test, and on mechanical hyperalgesia induced by carrageenan. mS100A9p inhibited thermal hyperalgesia induced by carrageenan. mS100A9p did not modify the nociceptive response in hot plate or tail-flick tests. These data demonstrate that the C-terminus of S100A9 protein interferes with control mechanisms of inflammatory pain.

Authors+Show Affiliations

Laboratory of Pathophysiology, Butantan Institute, Av. Vital Brazil 1500, São Paulo, SP 05503-900, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16920226

Citation

Dale, Camila Squarzoni, et al. "Effect of the C-terminus of Murine S100A9 Protein On Experimental Nociception." Peptides, vol. 27, no. 11, 2006, pp. 2794-802.
Dale CS, Pagano Rde L, Paccola CC, et al. Effect of the C-terminus of murine S100A9 protein on experimental nociception. Peptides. 2006;27(11):2794-802.
Dale, C. S., Pagano, R. d. e. . L., Paccola, C. C., Pinotti-Guirao, T., Juliano, M. A., Juliano, L., & Giorgi, R. (2006). Effect of the C-terminus of murine S100A9 protein on experimental nociception. Peptides, 27(11), 2794-802.
Dale CS, et al. Effect of the C-terminus of Murine S100A9 Protein On Experimental Nociception. Peptides. 2006;27(11):2794-802. PubMed PMID: 16920226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of the C-terminus of murine S100A9 protein on experimental nociception. AU - Dale,Camila Squarzoni, AU - Pagano,Rosana de Lima, AU - Paccola,Carina Cicconi, AU - Pinotti-Guirao,Tatiana, AU - Juliano,Maria Aparecida, AU - Juliano,Luiz, AU - Giorgi,Renata, Y1 - 2006/08/21/ PY - 2006/05/17/received PY - 2006/07/04/revised PY - 2006/07/06/accepted PY - 2006/8/22/pubmed PY - 2007/5/11/medline PY - 2006/8/22/entrez SP - 2794 EP - 802 JF - Peptides JO - Peptides VL - 27 IS - 11 N2 - Calcium-binding protein S100A9 induces antinociception in mice evaluated by the writhing test. Similarly, a peptide identical to the C-terminus of murine S100A9 (mS100A9p) inhibits the hyperalgesia induced by jararhagin, a metalloprotease. Thus, we investigated the effect of mS100A9p on different models used to evaluate nociception. mS100A9p induced a dose-dependent inhibitory effect on the writhing test, and on mechanical hyperalgesia induced by carrageenan. mS100A9p inhibited thermal hyperalgesia induced by carrageenan. mS100A9p did not modify the nociceptive response in hot plate or tail-flick tests. These data demonstrate that the C-terminus of S100A9 protein interferes with control mechanisms of inflammatory pain. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/16920226/Effect_of_the_C_terminus_of_murine_S100A9_protein_on_experimental_nociception_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196-9781(06)00314-7 DB - PRIME DP - Unbound Medicine ER -