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The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study.
Psychiatry Res 2006; 147(2-3):93-103PR

Abstract

The fornix and mammillary bodies are important limbic structures that have not been systematically investigated in the earliest stages of preclinical dementia. The present study examined volumetric changes in the fornix and mammillary bodies and improved previously established tracing guidelines to increase reliability and provide more comprehensive measurements. Volumetric measurements were made in euthymic older adults, including 16 patients with mild Alzheimer's disease (AD), 20 patients with amnestic mild cognitive impairment (MCI), 20 individuals with cognitive complaints (CC) but normal neuropsychological test performance, and 20 demographically matched healthy controls (HC). Structural magnetic resonance imaging included a T1-weighted 1.5-mm coronal volume, acquired on a GE 1.5T LX scanner. After adjustment for total intracranial volume (ICV), significant volume reductions were observed in the fornix and mammillary bodies in patients with AD as compared with HC, CC, and MCI participants. No volume differences were seen between the HC, CC, and MCI groups. Study findings are consistent with previous research showing volume decreases of the fornix and mammillary bodies in AD, and provide new data on the relative preservation of these structures in preclinical disease stages. Results suggest that atrophy of the fornix and mammillary bodies becomes apparent at the point of conversion from MCI to AD. Longitudinal assessments are needed to delineate the time course and extent of the observed volumetric changes.

Authors+Show Affiliations

Department of Psychology, Dartmouth College, Hanover, NH 03755, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16920336

Citation

Copenhaver, Brittany R., et al. "The Fornix and Mammillary Bodies in Older Adults With Alzheimer's Disease, Mild Cognitive Impairment, and Cognitive Complaints: a Volumetric MRI Study." Psychiatry Research, vol. 147, no. 2-3, 2006, pp. 93-103.
Copenhaver BR, Rabin LA, Saykin AJ, et al. The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study. Psychiatry Res. 2006;147(2-3):93-103.
Copenhaver, B. R., Rabin, L. A., Saykin, A. J., Roth, R. M., Wishart, H. A., Flashman, L. A., ... Mamourian, A. C. (2006). The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study. Psychiatry Research, 147(2-3), pp. 93-103.
Copenhaver BR, et al. The Fornix and Mammillary Bodies in Older Adults With Alzheimer's Disease, Mild Cognitive Impairment, and Cognitive Complaints: a Volumetric MRI Study. Psychiatry Res. 2006 Oct 30;147(2-3):93-103. PubMed PMID: 16920336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The fornix and mammillary bodies in older adults with Alzheimer's disease, mild cognitive impairment, and cognitive complaints: a volumetric MRI study. AU - Copenhaver,Brittany R, AU - Rabin,Laura A, AU - Saykin,Andrew J, AU - Roth,Robert M, AU - Wishart,Heather A, AU - Flashman,Laura A, AU - Santulli,Robert B, AU - McHugh,Tara L, AU - Mamourian,Alexander C, Y1 - 2006/08/22/ PY - 2005/09/13/received PY - 2006/01/21/revised PY - 2006/01/29/accepted PY - 2006/8/22/pubmed PY - 2006/12/9/medline PY - 2006/8/22/entrez SP - 93 EP - 103 JF - Psychiatry research JO - Psychiatry Res VL - 147 IS - 2-3 N2 - The fornix and mammillary bodies are important limbic structures that have not been systematically investigated in the earliest stages of preclinical dementia. The present study examined volumetric changes in the fornix and mammillary bodies and improved previously established tracing guidelines to increase reliability and provide more comprehensive measurements. Volumetric measurements were made in euthymic older adults, including 16 patients with mild Alzheimer's disease (AD), 20 patients with amnestic mild cognitive impairment (MCI), 20 individuals with cognitive complaints (CC) but normal neuropsychological test performance, and 20 demographically matched healthy controls (HC). Structural magnetic resonance imaging included a T1-weighted 1.5-mm coronal volume, acquired on a GE 1.5T LX scanner. After adjustment for total intracranial volume (ICV), significant volume reductions were observed in the fornix and mammillary bodies in patients with AD as compared with HC, CC, and MCI participants. No volume differences were seen between the HC, CC, and MCI groups. Study findings are consistent with previous research showing volume decreases of the fornix and mammillary bodies in AD, and provide new data on the relative preservation of these structures in preclinical disease stages. Results suggest that atrophy of the fornix and mammillary bodies becomes apparent at the point of conversion from MCI to AD. Longitudinal assessments are needed to delineate the time course and extent of the observed volumetric changes. SN - 0165-1781 UR - https://www.unboundmedicine.com/medline/citation/16920336/The_fornix_and_mammillary_bodies_in_older_adults_with_Alzheimer's_disease_mild_cognitive_impairment_and_cognitive_complaints:_a_volumetric_MRI_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4927(06)00020-5 DB - PRIME DP - Unbound Medicine ER -