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Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer.
Prostate. 2006 Oct 01; 66(14):1512-20.P

Abstract

BACKGROUND

The causes of prostate cancer are poorly understood, but genetic factors may be more important than for many other malignancies, and dietary phytoestrogens may be protective. Because phytoestrogens bind tightly to the estrogen receptor-beta, we conducted an epidemiologic investigation of synergistic effects between phytoestrogen intake and estrogen receptor-beta gene polymorphisms.

METHODS

We performed a population-based case-control study in Sweden. All participants reported their phytoestrogen intake and donated a blood sample. We identified four haplotype-tagging single nucleotide polymorphisms (htSNPs) and genotyped these htSNPs in 1314 prostate cancer patients and 782 controls. Odds ratios were estimated by multivariate logistic regression. Interactions between phytoestrogen intake and estrogen receptor-beta SNPs on prostate cancer risk were evaluated considering both multiplicative and additive effect scales.

RESULTS

We found a significant multiplicative interaction (P = 0.04) between dietary intake of phytoestrogens and a promoter SNP in the estrogen receptor-beta gene (rs 2987983-13950), but not with any of the three other htSNPs (P = 0.11, 0.69, 0.85). Among carriers of the variant promoter alleles, we found strong inverse associations with increasing intake of total phytoestrogens (odds ratio for highest vs. lowest quartile = 0.43; P for trend <0.001), isoflavonoids (odds ratio = 0.63; P for trend = 0.05), and coumestrol (odds ratio = 0.57; P for trend = 0.003). We found no association between phytoestrogens and prostate cancer among carriers homozygous for the wild-type allele (TT).

CONCLUSIONS

Our study provides strong evidence that high intake of phytoestrogens substantially reduce prostate cancer risk among men with specific polymorphic variation in the promoter region of the estrogen receptor-beta gene.

Authors+Show Affiliations

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. maria.hedelin@ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16921512

Citation

Hedelin, Maria, et al. "Dietary Intake of Phytoestrogens, Estrogen Receptor-beta Polymorphisms and the Risk of Prostate Cancer." The Prostate, vol. 66, no. 14, 2006, pp. 1512-20.
Hedelin M, Bälter KA, Chang ET, et al. Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer. Prostate. 2006;66(14):1512-20.
Hedelin, M., Bälter, K. A., Chang, E. T., Bellocco, R., Klint, A., Johansson, J. E., Wiklund, F., Thellenberg-Karlsson, C., Adami, H. O., & Grönberg, H. (2006). Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer. The Prostate, 66(14), 1512-20.
Hedelin M, et al. Dietary Intake of Phytoestrogens, Estrogen Receptor-beta Polymorphisms and the Risk of Prostate Cancer. Prostate. 2006 Oct 1;66(14):1512-20. PubMed PMID: 16921512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of phytoestrogens, estrogen receptor-beta polymorphisms and the risk of prostate cancer. AU - Hedelin,Maria, AU - Bälter,Katarina Augustsson, AU - Chang,Ellen T, AU - Bellocco,Rino, AU - Klint,Asa, AU - Johansson,Jan-Erik, AU - Wiklund,Fredrik, AU - Thellenberg-Karlsson,Camilla, AU - Adami,Hans-Olov, AU - Grönberg,Henrik, PY - 2006/8/22/pubmed PY - 2006/11/3/medline PY - 2006/8/22/entrez SP - 1512 EP - 20 JF - The Prostate JO - Prostate VL - 66 IS - 14 N2 - BACKGROUND: The causes of prostate cancer are poorly understood, but genetic factors may be more important than for many other malignancies, and dietary phytoestrogens may be protective. Because phytoestrogens bind tightly to the estrogen receptor-beta, we conducted an epidemiologic investigation of synergistic effects between phytoestrogen intake and estrogen receptor-beta gene polymorphisms. METHODS: We performed a population-based case-control study in Sweden. All participants reported their phytoestrogen intake and donated a blood sample. We identified four haplotype-tagging single nucleotide polymorphisms (htSNPs) and genotyped these htSNPs in 1314 prostate cancer patients and 782 controls. Odds ratios were estimated by multivariate logistic regression. Interactions between phytoestrogen intake and estrogen receptor-beta SNPs on prostate cancer risk were evaluated considering both multiplicative and additive effect scales. RESULTS: We found a significant multiplicative interaction (P = 0.04) between dietary intake of phytoestrogens and a promoter SNP in the estrogen receptor-beta gene (rs 2987983-13950), but not with any of the three other htSNPs (P = 0.11, 0.69, 0.85). Among carriers of the variant promoter alleles, we found strong inverse associations with increasing intake of total phytoestrogens (odds ratio for highest vs. lowest quartile = 0.43; P for trend <0.001), isoflavonoids (odds ratio = 0.63; P for trend = 0.05), and coumestrol (odds ratio = 0.57; P for trend = 0.003). We found no association between phytoestrogens and prostate cancer among carriers homozygous for the wild-type allele (TT). CONCLUSIONS: Our study provides strong evidence that high intake of phytoestrogens substantially reduce prostate cancer risk among men with specific polymorphic variation in the promoter region of the estrogen receptor-beta gene. SN - 0270-4137 UR - https://www.unboundmedicine.com/medline/citation/16921512/Dietary_intake_of_phytoestrogens_estrogen_receptor_beta_polymorphisms_and_the_risk_of_prostate_cancer_ L2 - https://doi.org/10.1002/pros.20487 DB - PRIME DP - Unbound Medicine ER -