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Effect of prophylactic sucralfate suspension on stomatitis induced by cancer chemotherapy. A randomized, double-blind cross-over study.
Acta Oncol. 1990; 29(2):171-3.AO

Abstract

We have studied whether mouth-swishing with sucralfate, a well-known gastric mucosal protective agent, may be used as prophylaxis against chemotherapy-induced stomatitis. Using radioactively labelled sucralfate we found that 20-30% was still bound to the oral mucosal lining 2 1/2 h after mouth-swishing. Forty patients receiving cisplatin and continuous infusion with 5-fluorouracil (5-FU) for 5 days entered a double-blind placebo-controlled cross-over study. Among 23 evaluable patients a significant reduction (p = 0.04) in an objective score of edema, erythema, erosion and ulcerations was seen during treatment with sucralfate. Patient preference favored sucralfate, but this preference failed to reach statistical significance (p = 0.06). Seven patients were inevaluable for reasons not associated with the study treatment. However, ten patients did not complete the study since the swishing procedure aggravated chemotherapy-induced nausea. An equal rate of non-compliance was seen with sucralfate and placebo. To overcome this problem, the oral medication should have a neutral taste, the solution should not be swallowed after the swishing, which should not be started until the nausea had ceased.

Authors+Show Affiliations

Department of Oncology, Odense University Hospital, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1692228

Citation

Pfeiffer, P, et al. "Effect of Prophylactic Sucralfate Suspension On Stomatitis Induced By Cancer Chemotherapy. a Randomized, Double-blind Cross-over Study." Acta Oncologica (Stockholm, Sweden), vol. 29, no. 2, 1990, pp. 171-3.
Pfeiffer P, Madsen EL, Hansen O, et al. Effect of prophylactic sucralfate suspension on stomatitis induced by cancer chemotherapy. A randomized, double-blind cross-over study. Acta Oncol. 1990;29(2):171-3.
Pfeiffer, P., Madsen, E. L., Hansen, O., & May, O. (1990). Effect of prophylactic sucralfate suspension on stomatitis induced by cancer chemotherapy. A randomized, double-blind cross-over study. Acta Oncologica (Stockholm, Sweden), 29(2), 171-3.
Pfeiffer P, et al. Effect of Prophylactic Sucralfate Suspension On Stomatitis Induced By Cancer Chemotherapy. a Randomized, Double-blind Cross-over Study. Acta Oncol. 1990;29(2):171-3. PubMed PMID: 1692228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of prophylactic sucralfate suspension on stomatitis induced by cancer chemotherapy. A randomized, double-blind cross-over study. AU - Pfeiffer,P, AU - Madsen,E L, AU - Hansen,O, AU - May,O, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 171 EP - 3 JF - Acta oncologica (Stockholm, Sweden) JO - Acta Oncol VL - 29 IS - 2 N2 - We have studied whether mouth-swishing with sucralfate, a well-known gastric mucosal protective agent, may be used as prophylaxis against chemotherapy-induced stomatitis. Using radioactively labelled sucralfate we found that 20-30% was still bound to the oral mucosal lining 2 1/2 h after mouth-swishing. Forty patients receiving cisplatin and continuous infusion with 5-fluorouracil (5-FU) for 5 days entered a double-blind placebo-controlled cross-over study. Among 23 evaluable patients a significant reduction (p = 0.04) in an objective score of edema, erythema, erosion and ulcerations was seen during treatment with sucralfate. Patient preference favored sucralfate, but this preference failed to reach statistical significance (p = 0.06). Seven patients were inevaluable for reasons not associated with the study treatment. However, ten patients did not complete the study since the swishing procedure aggravated chemotherapy-induced nausea. An equal rate of non-compliance was seen with sucralfate and placebo. To overcome this problem, the oral medication should have a neutral taste, the solution should not be swallowed after the swishing, which should not be started until the nausea had ceased. SN - 0284-186X UR - https://www.unboundmedicine.com/medline/citation/1692228/Effect_of_prophylactic_sucralfate_suspension_on_stomatitis_induced_by_cancer_chemotherapy__A_randomized_double_blind_cross_over_study_ L2 - http://www.tandfonline.com/doi/full/10.3109/02841869009126540 DB - PRIME DP - Unbound Medicine ER -