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Predicting isolated postchallenge hyperglycaemia: a new approach; Tehran Lipid and Glucose Study (TLGS).
Diabet Med. 2006 Sep; 23(9):982-9.DM

Abstract

AIMS

To determine factors predicting isolated postchallenge hyperglycaemia (IPH) defined as fasting plasma glucose (FPG) < 7.0 mmol/l and 2-h plasma glucose (2-hPG) >or= 11.1 mmol/l after an oral glucose tolerance test (OGTT) and factors influencing the value of 2-hPG in a population-based study.

MATERIALS AND METHODS

From 15,005 participants in the Tehran Lipid and Glucose Study (TLGS), we analysed the results of OGTTs in 5386 individuals (2909 women and 2437 men) aged >or= 20 years, free of known diabetes and any other disorders influencing glucose metabolism. Logistic and multiple linear regression models were developed to predict IPH and the 2-hPG, respectively.

RESULTS

The overall prevalence of non-diabetic subjects, IPH and undiagnosed Type 2 diabetes mellitus (FPG >or= 7.0 mmol/l) were 94.5% (n = 5088), 2.5% (n = 133) and 3.1% (n = 165), respectively. Of subjects with IPH, 29.3% (n = 39) had FPG levels < 5.6 mmol/l. Factors associated with IPH were FPG (mmol/l) [odds ratio (OR) 11.05, 95% confidence interval (CI) 7.9, 15.4], age >or= 40 years (OR 2.0, 95% CI 1.3, 3.2), abnormal waist circumference (OR 2.1, 95% CI 1.4, 3.1) and serum triglycerides >or= 1.7 mmol/l (OR 2.0, 95% CI 1.3, 3.1). In the multiple linear regression model, six explanatory factors (FPG, age, female sex, triglycerides, systolic blood pressure, waist circumference) were positively related to 2-hPG.

CONCLUSIONS

The model could predict 47.7% of total variance of 2-hPG. Based on our results in this Iranian population, OGTT can be recommended in subjects with FPG < 7.0 mmol/l in the presence of abnormal waist circumference and triglycerides, age >or= 40 years and in particular when FPG is close to 7.0 mmol/l.

Authors+Show Affiliations

Endocrine Research Centre, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16922704

Citation

Hosseinpanah, F, et al. "Predicting Isolated Postchallenge Hyperglycaemia: a New Approach; Tehran Lipid and Glucose Study (TLGS)." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 23, no. 9, 2006, pp. 982-9.
Hosseinpanah F, Rambod M, Reza Ghaffari HR, et al. Predicting isolated postchallenge hyperglycaemia: a new approach; Tehran Lipid and Glucose Study (TLGS). Diabet Med. 2006;23(9):982-9.
Hosseinpanah, F., Rambod, M., Reza Ghaffari, H. R., & Azizi, F. (2006). Predicting isolated postchallenge hyperglycaemia: a new approach; Tehran Lipid and Glucose Study (TLGS). Diabetic Medicine : a Journal of the British Diabetic Association, 23(9), 982-9.
Hosseinpanah F, et al. Predicting Isolated Postchallenge Hyperglycaemia: a New Approach; Tehran Lipid and Glucose Study (TLGS). Diabet Med. 2006;23(9):982-9. PubMed PMID: 16922704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicting isolated postchallenge hyperglycaemia: a new approach; Tehran Lipid and Glucose Study (TLGS). AU - Hosseinpanah,F, AU - Rambod,M, AU - Reza Ghaffari,H R, AU - Azizi,F, PY - 2006/8/23/pubmed PY - 2007/4/5/medline PY - 2006/8/23/entrez SP - 982 EP - 9 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet. Med. VL - 23 IS - 9 N2 - AIMS: To determine factors predicting isolated postchallenge hyperglycaemia (IPH) defined as fasting plasma glucose (FPG) < 7.0 mmol/l and 2-h plasma glucose (2-hPG) >or= 11.1 mmol/l after an oral glucose tolerance test (OGTT) and factors influencing the value of 2-hPG in a population-based study. MATERIALS AND METHODS: From 15,005 participants in the Tehran Lipid and Glucose Study (TLGS), we analysed the results of OGTTs in 5386 individuals (2909 women and 2437 men) aged >or= 20 years, free of known diabetes and any other disorders influencing glucose metabolism. Logistic and multiple linear regression models were developed to predict IPH and the 2-hPG, respectively. RESULTS: The overall prevalence of non-diabetic subjects, IPH and undiagnosed Type 2 diabetes mellitus (FPG >or= 7.0 mmol/l) were 94.5% (n = 5088), 2.5% (n = 133) and 3.1% (n = 165), respectively. Of subjects with IPH, 29.3% (n = 39) had FPG levels < 5.6 mmol/l. Factors associated with IPH were FPG (mmol/l) [odds ratio (OR) 11.05, 95% confidence interval (CI) 7.9, 15.4], age >or= 40 years (OR 2.0, 95% CI 1.3, 3.2), abnormal waist circumference (OR 2.1, 95% CI 1.4, 3.1) and serum triglycerides >or= 1.7 mmol/l (OR 2.0, 95% CI 1.3, 3.1). In the multiple linear regression model, six explanatory factors (FPG, age, female sex, triglycerides, systolic blood pressure, waist circumference) were positively related to 2-hPG. CONCLUSIONS: The model could predict 47.7% of total variance of 2-hPG. Based on our results in this Iranian population, OGTT can be recommended in subjects with FPG < 7.0 mmol/l in the presence of abnormal waist circumference and triglycerides, age >or= 40 years and in particular when FPG is close to 7.0 mmol/l. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/16922704/Predicting_isolated_postchallenge_hyperglycaemia:_a_new_approach L2 - https://doi.org/10.1111/j.1464-5491.2006.01939.x DB - PRIME DP - Unbound Medicine ER -