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N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain.
J Neurochem. 2006 Sep; 98(5):1487-96.JN

Abstract

The modulation of histamine neuron activity by various non-competitive NMDA-receptor antagonists was evaluated by changes in tele-methylhistamine (t-MeHA) levels and histidine decarboxylase (hdc) mRNA expression induced in rodent brain. The NMDA open-channel blockers phencyclidine (PCP) and MK-801 enhanced t-MeHA levels in mouse brain by 50-60%. Ifenprodil, which interacts with polyamine sites of NR2B-containing NMDA receptors, had no effect. PCP also increased hdc mRNA expression in the rat tuberomammillary nucleus. The enhancement of t-MeHA levels elicited by MK-801 (ED50 of approximately 0.1 mg/kg) was observed in the hypothalamus, cerebral cortex, striatum and hippocampus. Control t-MeHA levels and the t-MeHA response to MK-801 were not different in male and female mice. Double immunostaining for HDC and NMDA receptor subunits showed that histamine neurons of the rat tuberomammillary nucleus express NMDA receptor subunit 1 (NR1) with NMDA receptor subunit 2A (NR2A) and NMDA receptor 2B subunit (NR2B). In addition, immunoreactivity for the neuronal glutamate transporter EAAC1 was observed near most histaminergic perikarya. Hence, these findings support the existence of histamine/glutamate functional interactions in the brain. The increase in histamine neuron activity induced by NMDA receptor antagonists further suggests a role of histamine neurons in psychotic disorders. In addition, the decrease in MK-801-induced hyperlocomotion observed in mice after administration of ciproxifan further strengthens the potential interest of H3-receptor antagonist/inverse agonists for the symptomatic treatment of schizophrenia.

Authors+Show Affiliations

INSERM, U573, Centre Paul Broca, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16923161

Citation

Faucard, Raphaël, et al. "N-methyl-D-aspartate Receptor Antagonists Enhance Histamine Neuron Activity in Rodent Brain." Journal of Neurochemistry, vol. 98, no. 5, 2006, pp. 1487-96.
Faucard R, Armand V, Héron A, et al. N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. J Neurochem. 2006;98(5):1487-96.
Faucard, R., Armand, V., Héron, A., Cochois, V., Schwartz, J. C., & Arrang, J. M. (2006). N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. Journal of Neurochemistry, 98(5), 1487-96.
Faucard R, et al. N-methyl-D-aspartate Receptor Antagonists Enhance Histamine Neuron Activity in Rodent Brain. J Neurochem. 2006;98(5):1487-96. PubMed PMID: 16923161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. AU - Faucard,Raphaël, AU - Armand,Vincent, AU - Héron,Anne, AU - Cochois,Véronique, AU - Schwartz,Jean-Charles, AU - Arrang,Jean-Michel, PY - 2006/8/23/pubmed PY - 2006/10/4/medline PY - 2006/8/23/entrez SP - 1487 EP - 96 JF - Journal of neurochemistry JO - J Neurochem VL - 98 IS - 5 N2 - The modulation of histamine neuron activity by various non-competitive NMDA-receptor antagonists was evaluated by changes in tele-methylhistamine (t-MeHA) levels and histidine decarboxylase (hdc) mRNA expression induced in rodent brain. The NMDA open-channel blockers phencyclidine (PCP) and MK-801 enhanced t-MeHA levels in mouse brain by 50-60%. Ifenprodil, which interacts with polyamine sites of NR2B-containing NMDA receptors, had no effect. PCP also increased hdc mRNA expression in the rat tuberomammillary nucleus. The enhancement of t-MeHA levels elicited by MK-801 (ED50 of approximately 0.1 mg/kg) was observed in the hypothalamus, cerebral cortex, striatum and hippocampus. Control t-MeHA levels and the t-MeHA response to MK-801 were not different in male and female mice. Double immunostaining for HDC and NMDA receptor subunits showed that histamine neurons of the rat tuberomammillary nucleus express NMDA receptor subunit 1 (NR1) with NMDA receptor subunit 2A (NR2A) and NMDA receptor 2B subunit (NR2B). In addition, immunoreactivity for the neuronal glutamate transporter EAAC1 was observed near most histaminergic perikarya. Hence, these findings support the existence of histamine/glutamate functional interactions in the brain. The increase in histamine neuron activity induced by NMDA receptor antagonists further suggests a role of histamine neurons in psychotic disorders. In addition, the decrease in MK-801-induced hyperlocomotion observed in mice after administration of ciproxifan further strengthens the potential interest of H3-receptor antagonist/inverse agonists for the symptomatic treatment of schizophrenia. SN - 0022-3042 UR - https://www.unboundmedicine.com/medline/citation/16923161/N_methyl_D_aspartate_receptor_antagonists_enhance_histamine_neuron_activity_in_rodent_brain_ L2 - https://doi.org/10.1111/j.1471-4159.2006.04002.x DB - PRIME DP - Unbound Medicine ER -