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[Airway inflammation and lymphocyte subset analysis in patients with chronic obstructive pulmonary disease and healthy smokers].
Tuberk Toraks. 2006; 54(2):122-7.TT

Abstract

Chronic airway inflammation is reported to have an important role for the development of chronic obstructive pulmonary disease (COPD), in addition to smoking, genetic and environmental factors. The present study was aimed to investigate whether the airway inflammation differed in subjects with stable COPD and healthy smokers. A total of 35 subjects (18 patients with COPD and 17 healthy smokers) were enrolled in this study. Bronchoalveolar lavage (BAL) was performed via fiberoptic bronchoscope in all subjects and cell counts and profiles and lymphocyte subset were analyzed in BAL fluids. The number of neutrophils in BAL of subjects with stable COPD was significantly higher than that of the healthy smokers (p< 0.001), and the number of macrophages was significantly lower than that of the healthy smokers (p< 0.001). Although CD4+ T:CD8+ T lymphocyte ratio was higher in healty smokers, the difference was not significant (p> 0.05). As a result, the most marked cellular change in BAL of subjects with stable COPD is the increase in neutrophils and decrease in macrophages, suggesting a very important role in the chronic airflow limitation.

Authors+Show Affiliations

Department of Chest Diseases, Faculty of Medicine, Gazi University, Ankara, Turkey. ayurdakul@gazi.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

tur

PubMed ID

16924567

Citation

Yurdakul, Ahmet Selim, et al. "[Airway Inflammation and Lymphocyte Subset Analysis in Patients With Chronic Obstructive Pulmonary Disease and Healthy Smokers]." Tuberkuloz Ve Toraks, vol. 54, no. 2, 2006, pp. 122-7.
Yurdakul AS, Taci Hoca N, Cimen F, et al. [Airway inflammation and lymphocyte subset analysis in patients with chronic obstructive pulmonary disease and healthy smokers]. Tuberk Toraks. 2006;54(2):122-7.
Yurdakul, A. S., Taci Hoca, N., Cimen, F., Atikcan, S., Sipit, T., Atasever, M., & Balci, M. (2006). [Airway inflammation and lymphocyte subset analysis in patients with chronic obstructive pulmonary disease and healthy smokers]. Tuberkuloz Ve Toraks, 54(2), 122-7.
Yurdakul AS, et al. [Airway Inflammation and Lymphocyte Subset Analysis in Patients With Chronic Obstructive Pulmonary Disease and Healthy Smokers]. Tuberk Toraks. 2006;54(2):122-7. PubMed PMID: 16924567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Airway inflammation and lymphocyte subset analysis in patients with chronic obstructive pulmonary disease and healthy smokers]. AU - Yurdakul,Ahmet Selim, AU - Taci Hoca,Nevin, AU - Cimen,Filiz, AU - Atikcan,Sükran, AU - Sipit,Tuğrul, AU - Atasever,Melike, AU - Balci,Mustafa, PY - 2006/8/23/pubmed PY - 2006/10/13/medline PY - 2006/8/23/entrez SP - 122 EP - 7 JF - Tuberkuloz ve toraks JO - Tuberk Toraks VL - 54 IS - 2 N2 - Chronic airway inflammation is reported to have an important role for the development of chronic obstructive pulmonary disease (COPD), in addition to smoking, genetic and environmental factors. The present study was aimed to investigate whether the airway inflammation differed in subjects with stable COPD and healthy smokers. A total of 35 subjects (18 patients with COPD and 17 healthy smokers) were enrolled in this study. Bronchoalveolar lavage (BAL) was performed via fiberoptic bronchoscope in all subjects and cell counts and profiles and lymphocyte subset were analyzed in BAL fluids. The number of neutrophils in BAL of subjects with stable COPD was significantly higher than that of the healthy smokers (p< 0.001), and the number of macrophages was significantly lower than that of the healthy smokers (p< 0.001). Although CD4+ T:CD8+ T lymphocyte ratio was higher in healty smokers, the difference was not significant (p> 0.05). As a result, the most marked cellular change in BAL of subjects with stable COPD is the increase in neutrophils and decrease in macrophages, suggesting a very important role in the chronic airflow limitation. SN - 0494-1373 UR - https://www.unboundmedicine.com/medline/citation/16924567/[Airway_inflammation_and_lymphocyte_subset_analysis_in_patients_with_chronic_obstructive_pulmonary_disease_and_healthy_smokers]_ L2 - http://www.diseaseinfosearch.org/result/7979 DB - PRIME DP - Unbound Medicine ER -