Tags

Type your tag names separated by a space and hit enter

Degradation and drug release property of star poly(epsilon-caprolactone)s with dendritic cores.

Abstract

A series of star poly(epsilon-caprolactone)s (PCL) with dendritic cores, PAMAM-PCLs, were synthesized through the ring-opening polymerization of epsilon-caprolactone (CL) initiated by poly(amidoamine) dendrimer (PAMAM-OH). By controlling the feed ratio of the macroinitiator PAMAM-OH to the monomer CL, the star polymers with different branch lengths and properties can be obtained. The successful incorporation of PCL sequences onto the PAMAM-OH core was verified by FTIR, 1H NMR, and combined size-exclusion chromatography and multiangle laser light scattering analysis. The in vitro degradation of PAMAM-PCLs was investigated. The results show the hydrolytic degradation rate increases with increasing content of hydrophilic PAMAM-OH core. While the enzymatic degradation rate is affected by two competitive factors, the catalytic effect of Pseudomonas cepacia lipase on the degradation of PCL branches and the hydrophilicity that depends on the polymer composition. Using the PAMAM-PCLs with different molecular weights, the microsphere drug delivery systems with submicron sizes were fabricated using an "ultrasonic assisted precipitation method." The in vitro drug release from these microspheres was investigated.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16924617

Citation

Miao, Zhi-Mei, et al. "Degradation and Drug Release Property of Star Poly(epsilon-caprolactone)s With Dendritic Cores." Journal of Biomedical Materials Research. Part B, Applied Biomaterials, vol. 81, no. 1, 2007, pp. 40-9.
Miao ZM, Cheng SX, Zhang XZ, et al. Degradation and drug release property of star poly(epsilon-caprolactone)s with dendritic cores. J Biomed Mater Res Part B Appl Biomater. 2007;81(1):40-9.
Miao, Z. M., Cheng, S. X., Zhang, X. Z., Wang, Q. R., & Zhuo, R. X. (2007). Degradation and drug release property of star poly(epsilon-caprolactone)s with dendritic cores. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 81(1), pp. 40-9.
Miao ZM, et al. Degradation and Drug Release Property of Star Poly(epsilon-caprolactone)s With Dendritic Cores. J Biomed Mater Res Part B Appl Biomater. 2007;81(1):40-9. PubMed PMID: 16924617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Degradation and drug release property of star poly(epsilon-caprolactone)s with dendritic cores. AU - Miao,Zhi-Mei, AU - Cheng,Si-Xue, AU - Zhang,Xian-Zheng, AU - Wang,Qing-Rong, AU - Zhuo,Ren-Xi, PY - 2006/8/23/pubmed PY - 2007/6/5/medline PY - 2006/8/23/entrez SP - 40 EP - 9 JF - Journal of biomedical materials research. Part B, Applied biomaterials JO - J. Biomed. Mater. Res. Part B Appl. Biomater. VL - 81 IS - 1 N2 - A series of star poly(epsilon-caprolactone)s (PCL) with dendritic cores, PAMAM-PCLs, were synthesized through the ring-opening polymerization of epsilon-caprolactone (CL) initiated by poly(amidoamine) dendrimer (PAMAM-OH). By controlling the feed ratio of the macroinitiator PAMAM-OH to the monomer CL, the star polymers with different branch lengths and properties can be obtained. The successful incorporation of PCL sequences onto the PAMAM-OH core was verified by FTIR, 1H NMR, and combined size-exclusion chromatography and multiangle laser light scattering analysis. The in vitro degradation of PAMAM-PCLs was investigated. The results show the hydrolytic degradation rate increases with increasing content of hydrophilic PAMAM-OH core. While the enzymatic degradation rate is affected by two competitive factors, the catalytic effect of Pseudomonas cepacia lipase on the degradation of PCL branches and the hydrophilicity that depends on the polymer composition. Using the PAMAM-PCLs with different molecular weights, the microsphere drug delivery systems with submicron sizes were fabricated using an "ultrasonic assisted precipitation method." The in vitro drug release from these microspheres was investigated. SN - 1552-4973 UR - https://www.unboundmedicine.com/medline/citation/16924617/Degradation_and_drug_release_property_of_star_poly_epsilon_caprolactone_s_with_dendritic_cores_ L2 - https://doi.org/10.1002/jbm.b.30634 DB - PRIME DP - Unbound Medicine ER -