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Influence of drinking alcohol on atherosclerotic risk in alcohol flushers and non-flushers of Oriental patients with type 2 diabetes mellitus.
Alcohol Alcohol. 2006 Nov-Dec; 41(6):672-7.AA

Abstract

AIMS

Facial flushing caused by alcohol drinking is a typical symptom of high sensitivity to alcohol in orientals. We investigated whether drinking alcohol influences atherosclerotic risk factors in alcohol flushers and non-flushers in patients with diabetes mellitus.

METHODS

A cross-sectional study was performed using 225 subjects with type 2 diabetes. Sensitivity to alcohol was surveyed by a questionnaire on facial flushing. Subjects were divided into three groups by average amount of alcohol drinking (non-drinkers; light drinkers: <140 g/week; heavy drinkers: 140 g/week or more).

RESULTS

Systolic blood pressure and blood HDL cholesterol were significantly higher in heavy drinkers than in non-drinkers. There were no significant differences in body mass index, blood pressure, blood total cholesterol, HDL cholesterol, uric acid, fibrinogen and sialic acid levels in flushers and non-flushers. In alcohol flushers, diastolic blood pressure and HDL cholesterol in heavy drinkers were significantly higher than those in non-drinkers, and systolic blood pressure was significantly higher in heavy drinkers than in non-drinkers and light drinkers. On the other hand, blood pressure and HDL cholesterol in non-flushers were not significantly different among non-, light and heavy drinkers. Serum total cholesterol was not significantly different among the three drinking groups both in flushers and non-flushers.

CONCLUSIONS

Blood pressure and HDL cholesterol are more prone to be affected by drinking in flushers than in non-flushers, suggesting that alcohol sensitivity evaluated by flushing response due to drinking alcohol should be taken into account when the effects of alcohol drinking on atherosclerotic risk factors are considered in oriental patients with type 2 diabetes mellitus.

Authors+Show Affiliations

Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata, Japan. wakabaya@med.id.yamagata-u.ac.jpNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16926173

Citation

Wakabayashi, I, and H Masuda. "Influence of Drinking Alcohol On Atherosclerotic Risk in Alcohol Flushers and Non-flushers of Oriental Patients With Type 2 Diabetes Mellitus." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 41, no. 6, 2006, pp. 672-7.
Wakabayashi I, Masuda H. Influence of drinking alcohol on atherosclerotic risk in alcohol flushers and non-flushers of Oriental patients with type 2 diabetes mellitus. Alcohol Alcohol. 2006;41(6):672-7.
Wakabayashi, I., & Masuda, H. (2006). Influence of drinking alcohol on atherosclerotic risk in alcohol flushers and non-flushers of Oriental patients with type 2 diabetes mellitus. Alcohol and Alcoholism (Oxford, Oxfordshire), 41(6), 672-7.
Wakabayashi I, Masuda H. Influence of Drinking Alcohol On Atherosclerotic Risk in Alcohol Flushers and Non-flushers of Oriental Patients With Type 2 Diabetes Mellitus. Alcohol Alcohol. 2006 Nov-Dec;41(6):672-7. PubMed PMID: 16926173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of drinking alcohol on atherosclerotic risk in alcohol flushers and non-flushers of Oriental patients with type 2 diabetes mellitus. AU - Wakabayashi,I, AU - Masuda,H, Y1 - 2006/08/21/ PY - 2006/8/24/pubmed PY - 2007/2/21/medline PY - 2006/8/24/entrez SP - 672 EP - 7 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol. VL - 41 IS - 6 N2 - AIMS: Facial flushing caused by alcohol drinking is a typical symptom of high sensitivity to alcohol in orientals. We investigated whether drinking alcohol influences atherosclerotic risk factors in alcohol flushers and non-flushers in patients with diabetes mellitus. METHODS: A cross-sectional study was performed using 225 subjects with type 2 diabetes. Sensitivity to alcohol was surveyed by a questionnaire on facial flushing. Subjects were divided into three groups by average amount of alcohol drinking (non-drinkers; light drinkers: <140 g/week; heavy drinkers: 140 g/week or more). RESULTS: Systolic blood pressure and blood HDL cholesterol were significantly higher in heavy drinkers than in non-drinkers. There were no significant differences in body mass index, blood pressure, blood total cholesterol, HDL cholesterol, uric acid, fibrinogen and sialic acid levels in flushers and non-flushers. In alcohol flushers, diastolic blood pressure and HDL cholesterol in heavy drinkers were significantly higher than those in non-drinkers, and systolic blood pressure was significantly higher in heavy drinkers than in non-drinkers and light drinkers. On the other hand, blood pressure and HDL cholesterol in non-flushers were not significantly different among non-, light and heavy drinkers. Serum total cholesterol was not significantly different among the three drinking groups both in flushers and non-flushers. CONCLUSIONS: Blood pressure and HDL cholesterol are more prone to be affected by drinking in flushers than in non-flushers, suggesting that alcohol sensitivity evaluated by flushing response due to drinking alcohol should be taken into account when the effects of alcohol drinking on atherosclerotic risk factors are considered in oriental patients with type 2 diabetes mellitus. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/16926173/Influence_of_drinking_alcohol_on_atherosclerotic_risk_in_alcohol_flushers_and_non_flushers_of_Oriental_patients_with_type_2_diabetes_mellitus_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agl067 DB - PRIME DP - Unbound Medicine ER -