Tags

Type your tag names separated by a space and hit enter

Emerging resistance to carbapenems in a tertiary care hospital in north India.
Indian J Med Res. 2006 Jul; 124(1):95-8.IJ

Abstract

BACKGROUND AND OBJECTIVES

Carbapenems are beta-lactam antibiotics, presently considered as most potent agents for treating multi-drug resistant Gram-negative bacilli infections. In India carbapenems available for use are meropenem and imipenem, introduced recently. Resistance to these has been reported in a few bacteria especially Pseudomonas spp. We therefore retrospectively evaluated the antibiotic susceptibility pattern to these agents amongst various clinical isolates in a tertiary care hospital in north India.

METHODS

In this study Gram-negative bacterial pathogens isolated from clinical samples were tested for extended spectrum beta lactamase (ESBL) production. All ESBL positive bacteria were tested for meropenem and imipenem activity pattern using NCCLS guidelines. A total of 2626 consecutively isolated Gram-negative bacteria, which tested positive for ESBL production by the double disk diffusion method, were included.

RESULTS

The different bacteria isolated were Pseudomonas spp. 759, Acinetobacter spp. 676, Escherichia coli 569, Klebsiella spp. 343, Enterobacter spp. 150, Citrobacter spp. 57 and Proteus spp. 72. Overall resistance to meropenem was more (22.16%) than imipenem (17.32%). Maximum resistance was seen in Pseudomonas spp. M(R) 37.6 per cent, I(R) 30 per cent. In isolates from intensive care units (ICU) resistance to carbapenems was significantly higher than non-ICU patients.

INTERPRETATION AND CONCLUSION

Resistance to meropenem and imipenem was seen in various clinical isolates of Gram-negative ESBL-positive bacteria. There is a need to alarm our clinicians for judicious use of antibiotics.

Authors+Show Affiliations

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16926463

Citation

Gupta, Ekta, et al. "Emerging Resistance to Carbapenems in a Tertiary Care Hospital in North India." The Indian Journal of Medical Research, vol. 124, no. 1, 2006, pp. 95-8.
Gupta E, Mohanty S, Sood S, et al. Emerging resistance to carbapenems in a tertiary care hospital in north India. Indian J Med Res. 2006;124(1):95-8.
Gupta, E., Mohanty, S., Sood, S., Dhawan, B., Das, B. K., & Kapil, A. (2006). Emerging resistance to carbapenems in a tertiary care hospital in north India. The Indian Journal of Medical Research, 124(1), 95-8.
Gupta E, et al. Emerging Resistance to Carbapenems in a Tertiary Care Hospital in North India. Indian J Med Res. 2006;124(1):95-8. PubMed PMID: 16926463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging resistance to carbapenems in a tertiary care hospital in north India. AU - Gupta,Ekta, AU - Mohanty,Srujana, AU - Sood,Seema, AU - Dhawan,Benu, AU - Das,Bimal K, AU - Kapil,Arti, PY - 2006/8/24/pubmed PY - 2006/10/27/medline PY - 2006/8/24/entrez SP - 95 EP - 8 JF - The Indian journal of medical research JO - Indian J. Med. Res. VL - 124 IS - 1 N2 - BACKGROUND AND OBJECTIVES: Carbapenems are beta-lactam antibiotics, presently considered as most potent agents for treating multi-drug resistant Gram-negative bacilli infections. In India carbapenems available for use are meropenem and imipenem, introduced recently. Resistance to these has been reported in a few bacteria especially Pseudomonas spp. We therefore retrospectively evaluated the antibiotic susceptibility pattern to these agents amongst various clinical isolates in a tertiary care hospital in north India. METHODS: In this study Gram-negative bacterial pathogens isolated from clinical samples were tested for extended spectrum beta lactamase (ESBL) production. All ESBL positive bacteria were tested for meropenem and imipenem activity pattern using NCCLS guidelines. A total of 2626 consecutively isolated Gram-negative bacteria, which tested positive for ESBL production by the double disk diffusion method, were included. RESULTS: The different bacteria isolated were Pseudomonas spp. 759, Acinetobacter spp. 676, Escherichia coli 569, Klebsiella spp. 343, Enterobacter spp. 150, Citrobacter spp. 57 and Proteus spp. 72. Overall resistance to meropenem was more (22.16%) than imipenem (17.32%). Maximum resistance was seen in Pseudomonas spp. M(R) 37.6 per cent, I(R) 30 per cent. In isolates from intensive care units (ICU) resistance to carbapenems was significantly higher than non-ICU patients. INTERPRETATION AND CONCLUSION: Resistance to meropenem and imipenem was seen in various clinical isolates of Gram-negative ESBL-positive bacteria. There is a need to alarm our clinicians for judicious use of antibiotics. SN - 0971-5916 UR - https://www.unboundmedicine.com/medline/citation/16926463/Emerging_resistance_to_carbapenems_in_a_tertiary_care_hospital_in_north_India_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -