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[Two new furostanol saponins from the rhizomes of Anemarrhena asphodeloides].
Yao Xue Xue Bao. 2006 Jun; 41(6):527-32.YX

Abstract

AIM

To investigate the chemical constituents of the rhizomes of Anemarrhena asphodeloides Bunge.

METHODS

The compounds were separated by means of solvent extraction, chromatography on absorbent resin SP825 and silica gel C18 repeatedly, and their structures were elucidated on the basis of chemical methods and spectral analyses (FAB-MS, 1H NMR, 13C NMR, 1H-1H COSY).

RESULTS

Six steroidal saponins were isolated from the rhizomes of Anemarrhena asphodeloides Bunge. They were identified as (25S)-26-O-beta-D-glucopyranosyl-22-hydroxy-5beta-furostane-2beta, 3beta, 26-triol-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranoside (timosaponin N, 1), timosaponin E1 (2), (25S)-26-O-beta-D-glucopyranosyl-22-methoxy-5beta-furostane-2beta, 3beta, 26-triol-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranoside (timosaponin O, 3) , timosaponin E2 (4), (25R) -26-O-beta-D-glucopyranosyl-22-hydroxy-5alpha-furostane-2alpha, 3beta, 26-triol-3-O-beta-D-glucopyranosyl-(1 --> 2)-[beta-D-xylpyranosyl-(1 --> 3)]-beta-D-glucopyranosyl-(1 --> 4)-beta-D-galactopyranoside (purpureagitosid, 5) and marcogenin-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranoside (6).

CONCLUSION

Compound 1 and compound 3 are new compounds, and compound 5 was isolated from the rhizomes of Anemarrhena asphodeloides Bunge for the first time.

Authors+Show Affiliations

Kang LP
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
Ma BP
No affiliation info available
Shi TJ
No affiliation info available
Zhang J
No affiliation info available
Xiong CQ
No affiliation info available

MeSH

AnemarrhenaMolecular ConformationMolecular StructurePlants, MedicinalRhizomeSaponins

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16927827

Citation

Kang, Li-Ping, et al. "[Two New Furostanol Saponins From the Rhizomes of Anemarrhena Asphodeloides]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 41, no. 6, 2006, pp. 527-32.
Kang LP, Ma BP, Shi TJ, et al. [Two new furostanol saponins from the rhizomes of Anemarrhena asphodeloides]. Yao Xue Xue Bao. 2006;41(6):527-32.
Kang, L. P., Ma, B. P., Shi, T. J., Zhang, J., & Xiong, C. Q. (2006). [Two new furostanol saponins from the rhizomes of Anemarrhena asphodeloides]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 41(6), 527-32.
Kang LP, et al. [Two New Furostanol Saponins From the Rhizomes of Anemarrhena Asphodeloides]. Yao Xue Xue Bao. 2006;41(6):527-32. PubMed PMID: 16927827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Two new furostanol saponins from the rhizomes of Anemarrhena asphodeloides]. AU - Kang,Li-Ping, AU - Ma,Bai-Ping, AU - Shi,Tian-Jun, AU - Zhang,Jie, AU - Xiong,Cheng-Qi, PY - 2006/8/25/pubmed PY - 2008/1/4/medline PY - 2006/8/25/entrez SP - 527 EP - 32 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 41 IS - 6 N2 - AIM: To investigate the chemical constituents of the rhizomes of Anemarrhena asphodeloides Bunge. METHODS: The compounds were separated by means of solvent extraction, chromatography on absorbent resin SP825 and silica gel C18 repeatedly, and their structures were elucidated on the basis of chemical methods and spectral analyses (FAB-MS, 1H NMR, 13C NMR, 1H-1H COSY). RESULTS: Six steroidal saponins were isolated from the rhizomes of Anemarrhena asphodeloides Bunge. They were identified as (25S)-26-O-beta-D-glucopyranosyl-22-hydroxy-5beta-furostane-2beta, 3beta, 26-triol-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranoside (timosaponin N, 1), timosaponin E1 (2), (25S)-26-O-beta-D-glucopyranosyl-22-methoxy-5beta-furostane-2beta, 3beta, 26-triol-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranoside (timosaponin O, 3) , timosaponin E2 (4), (25R) -26-O-beta-D-glucopyranosyl-22-hydroxy-5alpha-furostane-2alpha, 3beta, 26-triol-3-O-beta-D-glucopyranosyl-(1 --> 2)-[beta-D-xylpyranosyl-(1 --> 3)]-beta-D-glucopyranosyl-(1 --> 4)-beta-D-galactopyranoside (purpureagitosid, 5) and marcogenin-3-O-beta-D-glucopyranosyl-(1 --> 2)-beta-D-galactopyranoside (6). CONCLUSION: Compound 1 and compound 3 are new compounds, and compound 5 was isolated from the rhizomes of Anemarrhena asphodeloides Bunge for the first time. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/16927827/[Two_new_furostanol_saponins_from_the_rhizomes_of_Anemarrhena_asphodeloides]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:16927827 DB - PRIME DP - Unbound Medicine ER -