TY - JOUR T1 - Highly enantioselective direct aldol reaction catalyzed by organic molecules. AU - Raj,Monika, AU - Vishnumaya,Vishnumaya, AU - Ginotra,Sandeep K, AU - Singh,Vinod K, PY - 2006/8/25/pubmed PY - 2006/8/25/medline PY - 2006/8/25/entrez SP - 4097 EP - 9 JF - Organic letters JO - Org Lett VL - 8 IS - 18 N2 - We have demonstrated that a new class of l-proline-based organic compounds catalyzed the direct aldol reaction between aldehydes and acetone to provide beta-hydroxy ketones in good yields. The reaction is efficient, and 5-10 mol % of the catalyst and excellent enantioselectivities (97-99% ee) were obtained in both aromatic and aliphatic aldehydes. The presence of a gem-diphenyl group at the beta-carbon is necessary for high enantioselectivity. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/16928083/Highly_enantioselective_direct_aldol_reaction_catalyzed_by_organic_molecules_ L2 - https://doi.org/10.1021/ol0616081 DB - PRIME DP - Unbound Medicine ER -