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Phylloquinone intake and risk of cardiovascular diseases in men.
Nutr Metab Cardiovasc Dis 2007; 17(1):58-62NM

Abstract

BACKGROUND AND AIMS

Dietary patterns high in fruits and vegetables have been associated with lower risk of cardiovascular diseases. It is difficult to assess whether individuals are following a dietary pattern recommended for cardiovascular disease prevention in large population based studies. Therefore, the association between phylloquinone (vitamin K(1)) intake, derived mainly from green vegetables, and risk of cardiovascular diseases [total and fatal coronary heart disease (CHD), non-fatal myocardial infarction, total and ischemic stroke] was prospectively assessed.

METHODS AND RESULTS

The study was conducted in 40,087 men who participated in the Health Professionals' Follow-up Study during 1986-2000. There were 1857 CHD events and 617 strokes. After adjustment for lifestyle factors, the relative risks of total CHD events in increasing quintile categories of phylloquinone intake were 1 (reference), 0.84, 0.87, 0.82 and 0.84, respectively (P for trend 0.05). However, the risk of CHD events and strokes did not remain significantly associated with phylloquinone intake after adjustment for lifestyle and other dietary factors.

CONCLUSION

These results suggest that although not an independent risk factor, high phylloquinone intake may be a marker of dietary patterns associated with lower CHD risk and useful when used within that context.

Authors+Show Affiliations

Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. arja.erkkila@uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16928438

Citation

Erkkilä, Arja T., et al. "Phylloquinone Intake and Risk of Cardiovascular Diseases in Men." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 17, no. 1, 2007, pp. 58-62.
Erkkilä AT, Booth SL, Hu FB, et al. Phylloquinone intake and risk of cardiovascular diseases in men. Nutr Metab Cardiovasc Dis. 2007;17(1):58-62.
Erkkilä, A. T., Booth, S. L., Hu, F. B., Jacques, P. F., & Lichtenstein, A. H. (2007). Phylloquinone intake and risk of cardiovascular diseases in men. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 17(1), pp. 58-62.
Erkkilä AT, et al. Phylloquinone Intake and Risk of Cardiovascular Diseases in Men. Nutr Metab Cardiovasc Dis. 2007;17(1):58-62. PubMed PMID: 16928438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phylloquinone intake and risk of cardiovascular diseases in men. AU - Erkkilä,Arja T, AU - Booth,Sarah L, AU - Hu,Frank B, AU - Jacques,Paul F, AU - Lichtenstein,Alice H, Y1 - 2006/08/22/ PY - 2005/11/29/received PY - 2006/02/02/revised PY - 2006/03/31/accepted PY - 2006/8/25/pubmed PY - 2007/1/5/medline PY - 2006/8/25/entrez SP - 58 EP - 62 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 17 IS - 1 N2 - BACKGROUND AND AIMS: Dietary patterns high in fruits and vegetables have been associated with lower risk of cardiovascular diseases. It is difficult to assess whether individuals are following a dietary pattern recommended for cardiovascular disease prevention in large population based studies. Therefore, the association between phylloquinone (vitamin K(1)) intake, derived mainly from green vegetables, and risk of cardiovascular diseases [total and fatal coronary heart disease (CHD), non-fatal myocardial infarction, total and ischemic stroke] was prospectively assessed. METHODS AND RESULTS: The study was conducted in 40,087 men who participated in the Health Professionals' Follow-up Study during 1986-2000. There were 1857 CHD events and 617 strokes. After adjustment for lifestyle factors, the relative risks of total CHD events in increasing quintile categories of phylloquinone intake were 1 (reference), 0.84, 0.87, 0.82 and 0.84, respectively (P for trend 0.05). However, the risk of CHD events and strokes did not remain significantly associated with phylloquinone intake after adjustment for lifestyle and other dietary factors. CONCLUSION: These results suggest that although not an independent risk factor, high phylloquinone intake may be a marker of dietary patterns associated with lower CHD risk and useful when used within that context. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/16928438/Phylloquinone_intake_and_risk_of_cardiovascular_diseases_in_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(06)00100-1 DB - PRIME DP - Unbound Medicine ER -