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Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules.
Clin Pediatr (Phila). 2006 Sep; 45(7):613-20.CPed

Abstract

A sixth dose of tetanus, diphtheria, acellular pertussis (Tdap) vaccine in adolescents might produce a differing reactogenicity and/or immunogenicity response depending on the composition of the 5 prior doses of DTaP or DT-whole cell pertussis (DTwP) vaccine. Reactions and immune responses following receipt of the Sanofi Pasteur (Adacel) and GlaxoSmithKline (Boostrix) Tdap vaccines were assessed in 229 adolescents. No differences were observed for reactions to either Tdap vaccine regardless of the prior DTaP/DTwP vaccination history. Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic.

Authors+Show Affiliations

Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA. michael_pichichero@urmc.rochester.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16928838

Citation

Pichichero, Michael E., et al. "Acellular Pertussis Vaccine Boosters Combined With Diphtheria and Tetanus Toxoid Boosters for Adolescents: Safety and Immunogenicity Assessment when Preceded By Different 5-dose DTaP/DTwP Schedules." Clinical Pediatrics, vol. 45, no. 7, 2006, pp. 613-20.
Pichichero ME, Casey JR, Francis AB, et al. Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules. Clin Pediatr (Phila). 2006;45(7):613-20.
Pichichero, M. E., Casey, J. R., Francis, A. B., Marsocci, S. M., Murphy, M., Hoeger, W., & Cleary, C. (2006). Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules. Clinical Pediatrics, 45(7), 613-20.
Pichichero ME, et al. Acellular Pertussis Vaccine Boosters Combined With Diphtheria and Tetanus Toxoid Boosters for Adolescents: Safety and Immunogenicity Assessment when Preceded By Different 5-dose DTaP/DTwP Schedules. Clin Pediatr (Phila). 2006;45(7):613-20. PubMed PMID: 16928838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules. AU - Pichichero,Michael E, AU - Casey,Janet R, AU - Francis,Anne B, AU - Marsocci,Steven M, AU - Murphy,Marie, AU - Hoeger,William, AU - Cleary,Carolyn, PY - 2006/8/25/pubmed PY - 2007/2/3/medline PY - 2006/8/25/entrez SP - 613 EP - 20 JF - Clinical pediatrics JO - Clin Pediatr (Phila) VL - 45 IS - 7 N2 - A sixth dose of tetanus, diphtheria, acellular pertussis (Tdap) vaccine in adolescents might produce a differing reactogenicity and/or immunogenicity response depending on the composition of the 5 prior doses of DTaP or DT-whole cell pertussis (DTwP) vaccine. Reactions and immune responses following receipt of the Sanofi Pasteur (Adacel) and GlaxoSmithKline (Boostrix) Tdap vaccines were assessed in 229 adolescents. No differences were observed for reactions to either Tdap vaccine regardless of the prior DTaP/DTwP vaccination history. Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic. SN - 0009-9228 UR - https://www.unboundmedicine.com/medline/citation/16928838/Acellular_pertussis_vaccine_boosters_combined_with_diphtheria_and_tetanus_toxoid_boosters_for_adolescents:_safety_and_immunogenicity_assessment_when_preceded_by_different_5_dose_DTaP/DTwP_schedules_ L2 - https://journals.sagepub.com/doi/10.1177/0009922806289593?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -