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Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients.
Eur J Clin Nutr 2007; 61(2):200-4EJ

Abstract

OBJECTIVE

Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using a higher dose of arginine-enhanced diet (17 g/day) than previous studies, could improve nutritional variables as well as clinical outcomes, when compared with a control enteral diet.

DESIGN

Randomized clinical trial.

SETTING

Tertiary care.

SUBJECTS

A population of 72 patients with oral and laryngeal cancer was enrolled.

INTERVENTIONS

At surgery, patients were randomly allocated to two groups: (a) 35 patients receiving an arginine-enhanced formula with arginine (group I) and (b) 37 patients receiving an isocaloric, isonitrogenous enteral formula (group II).

RESULTS

No significant intergroup differences in the trend of the three plasma proteins (albumin, transferrin, prealbumin) and lymphocytes were detected. Episodes of diarrhea rate were equal in both groups (22.8% group I and 21.6% group II: NS). The postoperative infections complications were equal in both groups (5.7% group I and 5.4% group II: NS). Fistula (wound complication) was less frequent in enriched nutrition group (2.8% group I and 18.9% group II: P<0.05), whereas wound infection was similar in both groups. The length of postoperative stay was similar in both (27.9+/-21 vs 28.2+/-12 days; NS).

CONCLUSIONS

At this dose, arginine-enhanced formula improves fistula rates in postoperative head and neck cancer patients without a high rate of diarrhea.

Authors+Show Affiliations

Medicine School and Unit of Investigation, Institute of Endocrinology and Nutrition, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16929239

Citation

de Luis, D A., et al. "Clinical and Biochemical Outcomes After a Randomized Trial With a High Dose of Enteral Arginine Formula in Postsurgical Head and Neck Cancer Patients." European Journal of Clinical Nutrition, vol. 61, no. 2, 2007, pp. 200-4.
de Luis DA, Izaola O, Cuellar L, et al. Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. Eur J Clin Nutr. 2007;61(2):200-4.
de Luis, D. A., Izaola, O., Cuellar, L., Terroba, M. C., Martin, T., & Aller, R. (2007). Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. European Journal of Clinical Nutrition, 61(2), pp. 200-4.
de Luis DA, et al. Clinical and Biochemical Outcomes After a Randomized Trial With a High Dose of Enteral Arginine Formula in Postsurgical Head and Neck Cancer Patients. Eur J Clin Nutr. 2007;61(2):200-4. PubMed PMID: 16929239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and biochemical outcomes after a randomized trial with a high dose of enteral arginine formula in postsurgical head and neck cancer patients. AU - de Luis,D A, AU - Izaola,O, AU - Cuellar,L, AU - Terroba,M C, AU - Martin,T, AU - Aller,R, Y1 - 2006/08/23/ PY - 2006/8/25/pubmed PY - 2007/3/21/medline PY - 2006/8/25/entrez SP - 200 EP - 4 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 2 N2 - OBJECTIVE: Patients with head and neck cancer undergoing surgery have a high incidence of postoperative complications. The aim of our study was to investigate whether postoperative nutrition of head and neck cancer patients, using a higher dose of arginine-enhanced diet (17 g/day) than previous studies, could improve nutritional variables as well as clinical outcomes, when compared with a control enteral diet. DESIGN: Randomized clinical trial. SETTING: Tertiary care. SUBJECTS: A population of 72 patients with oral and laryngeal cancer was enrolled. INTERVENTIONS: At surgery, patients were randomly allocated to two groups: (a) 35 patients receiving an arginine-enhanced formula with arginine (group I) and (b) 37 patients receiving an isocaloric, isonitrogenous enteral formula (group II). RESULTS: No significant intergroup differences in the trend of the three plasma proteins (albumin, transferrin, prealbumin) and lymphocytes were detected. Episodes of diarrhea rate were equal in both groups (22.8% group I and 21.6% group II: NS). The postoperative infections complications were equal in both groups (5.7% group I and 5.4% group II: NS). Fistula (wound complication) was less frequent in enriched nutrition group (2.8% group I and 18.9% group II: P<0.05), whereas wound infection was similar in both groups. The length of postoperative stay was similar in both (27.9+/-21 vs 28.2+/-12 days; NS). CONCLUSIONS: At this dose, arginine-enhanced formula improves fistula rates in postoperative head and neck cancer patients without a high rate of diarrhea. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16929239/Clinical_and_biochemical_outcomes_after_a_randomized_trial_with_a_high_dose_of_enteral_arginine_formula_in_postsurgical_head_and_neck_cancer_patients_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602515 DB - PRIME DP - Unbound Medicine ER -