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Urinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii.
Eur J Clin Nutr. 2007 Feb; 61(2):255-61.EJ

Abstract

OBJECTIVE

To explore soy intake and urinary isoflavonoid excretion within several generations of American-Japanese women based on the hypothesis that earlier generations excrete higher levels of urinary isoflavonoids, in particular the metabolite equol, than later generations.

SUBJECTS

A convenience sample of 43 women from 19 families aged 18-78 years, all of whom reported at least 50% Japanese ancestry.

INTERVENTIONS

Each woman collected overnight urine samples at baseline and after consuming one serving of soymilk, both samples were analyzed for the isoflavonoids daidzein, genistein and equol using liquid chromatography-mass spectrometry.

RESULTS

Median isoflavone intakes during the last year were 7.2 mg/day for the first generation, 7.3 mg/day for the second generation and 6.3 mg/day for the third generation (P=0.36). At baseline, the median isoflavonoid excretion for the first generation was nonsignificantly higher than for later generations (190, 86 and 42 nmol/h; P=0.20) but after intervention, the median urinary isoflavonoid excretion was very similar for the three groups: 2465, 1895 and 2775 nmol/h (P=0.70). Following intervention, a nonsignificantly higher proportion of older than younger women (53 vs 32 and 33%; P=0.41) excreted the metabolite equol. The respective median equol excretion rates by generation following intervention were 39.5, 4.2 and 3.5 nmol/h (P=0.04).

CONCLUSIONS

This small investigation among three generations of Japanese-Americans detected a higher equol production among older women after a soy challenge, but no difference in the excretion of total isoflavonoids after a standardized dose of soymilk was observed.

Authors+Show Affiliations

Cancer Research Center of Hawaii, Honolulu, HI 96813, USA. gertraud@crch.hawaii.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16929241

Citation

Maskarinec, G, et al. "Urinary Isoflavonoid Excretion and Soy Consumption in Three Generations of Japanese Women in Hawaii." European Journal of Clinical Nutrition, vol. 61, no. 2, 2007, pp. 255-61.
Maskarinec G, Yamakawa R, Hebshi S, et al. Urinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii. Eur J Clin Nutr. 2007;61(2):255-61.
Maskarinec, G., Yamakawa, R., Hebshi, S., & Franke, A. A. (2007). Urinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii. European Journal of Clinical Nutrition, 61(2), 255-61.
Maskarinec G, et al. Urinary Isoflavonoid Excretion and Soy Consumption in Three Generations of Japanese Women in Hawaii. Eur J Clin Nutr. 2007;61(2):255-61. PubMed PMID: 16929241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary isoflavonoid excretion and soy consumption in three generations of Japanese women in Hawaii. AU - Maskarinec,G, AU - Yamakawa,R, AU - Hebshi,S, AU - Franke,A A, Y1 - 2006/08/16/ PY - 2006/8/25/pubmed PY - 2007/3/21/medline PY - 2006/8/25/entrez SP - 255 EP - 61 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 2 N2 - OBJECTIVE: To explore soy intake and urinary isoflavonoid excretion within several generations of American-Japanese women based on the hypothesis that earlier generations excrete higher levels of urinary isoflavonoids, in particular the metabolite equol, than later generations. SUBJECTS: A convenience sample of 43 women from 19 families aged 18-78 years, all of whom reported at least 50% Japanese ancestry. INTERVENTIONS: Each woman collected overnight urine samples at baseline and after consuming one serving of soymilk, both samples were analyzed for the isoflavonoids daidzein, genistein and equol using liquid chromatography-mass spectrometry. RESULTS: Median isoflavone intakes during the last year were 7.2 mg/day for the first generation, 7.3 mg/day for the second generation and 6.3 mg/day for the third generation (P=0.36). At baseline, the median isoflavonoid excretion for the first generation was nonsignificantly higher than for later generations (190, 86 and 42 nmol/h; P=0.20) but after intervention, the median urinary isoflavonoid excretion was very similar for the three groups: 2465, 1895 and 2775 nmol/h (P=0.70). Following intervention, a nonsignificantly higher proportion of older than younger women (53 vs 32 and 33%; P=0.41) excreted the metabolite equol. The respective median equol excretion rates by generation following intervention were 39.5, 4.2 and 3.5 nmol/h (P=0.04). CONCLUSIONS: This small investigation among three generations of Japanese-Americans detected a higher equol production among older women after a soy challenge, but no difference in the excretion of total isoflavonoids after a standardized dose of soymilk was observed. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16929241/Urinary_isoflavonoid_excretion_and_soy_consumption_in_three_generations_of_Japanese_women_in_Hawaii_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602511 DB - PRIME DP - Unbound Medicine ER -