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Dorsal sural nerve conduction study in vitamin B(12) deficiency with megaloblastic anemia.
J Peripher Nerv Syst. 2006 Sep; 11(3):247-52.JP

Abstract

Peripheral neuropathy is frequently observed in B(12) deficiency. In spite of this, there is little knowledge about peripheral neuropathy in B(12) deficiency because the severity of clinical involvement of the central nervous system clearly outweighs signs and symptoms due to peripheral nervous system involvement. We primarily investigated peripheral neuropathy with dorsal sural conduction study, which is a new method for detection of early peripheral neuropathy, in B(12) deficiency with megaloblastic anemia. Conventional nerve conduction studies and tibial sensory-evoked potential (SEP) recording were also performed. Twenty-eight B(12)-deficient patients (15 male, 13 female, mean age 65.8 years) with megaloblastic anemia and 18 age- and sex-matched controls were included in the study. Although dorsal sural sensory nerve action potentials (SNAPs) were not recorded in 15 (54%) of 28 patients, only 9 (32%) of them were found to have polyneuropathy by conventional conduction studies. Furthermore, patients with dorsal sural SNAP had mean lower amplitude, mean longer latency, and slower velocity response when compared with controls. Twenty patients (71%) were diagnosed as having myelopathy by the combination of tibial SEP and neurological findings. Two patients whose dorsal sural SNAPs were not recorded had normal tibial SEP responses; therefore, these patients were considered to have isolated peripheral neuropathy. As a result, we conclude that dorsal sural nerve conduction study is a reliable method for detection of early peripheral neuropathy in B(12) deficiency.

Authors+Show Affiliations

Department of Medicine, Division of Hematology, Trakya Medical Faculty, University of Trakya, Edirne, Turkey. burhanturgut@trakya.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16930287

Citation

Turgut, Burhan, et al. "Dorsal Sural Nerve Conduction Study in Vitamin B(12) Deficiency With Megaloblastic Anemia." Journal of the Peripheral Nervous System : JPNS, vol. 11, no. 3, 2006, pp. 247-52.
Turgut B, Turgut N, Akpinar S, et al. Dorsal sural nerve conduction study in vitamin B(12) deficiency with megaloblastic anemia. J Peripher Nerv Syst. 2006;11(3):247-52.
Turgut, B., Turgut, N., Akpinar, S., Balci, K., Pamuk, G. E., Tekgündüz, E., & Demir, M. (2006). Dorsal sural nerve conduction study in vitamin B(12) deficiency with megaloblastic anemia. Journal of the Peripheral Nervous System : JPNS, 11(3), 247-52.
Turgut B, et al. Dorsal Sural Nerve Conduction Study in Vitamin B(12) Deficiency With Megaloblastic Anemia. J Peripher Nerv Syst. 2006;11(3):247-52. PubMed PMID: 16930287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal sural nerve conduction study in vitamin B(12) deficiency with megaloblastic anemia. AU - Turgut,Burhan, AU - Turgut,Nilda, AU - Akpinar,Seval, AU - Balci,Kemal, AU - Pamuk,Gülsüm E, AU - Tekgündüz,Emre, AU - Demir,Muzaffer, PY - 2006/8/26/pubmed PY - 2006/10/25/medline PY - 2006/8/26/entrez SP - 247 EP - 52 JF - Journal of the peripheral nervous system : JPNS JO - J. Peripher. Nerv. Syst. VL - 11 IS - 3 N2 - Peripheral neuropathy is frequently observed in B(12) deficiency. In spite of this, there is little knowledge about peripheral neuropathy in B(12) deficiency because the severity of clinical involvement of the central nervous system clearly outweighs signs and symptoms due to peripheral nervous system involvement. We primarily investigated peripheral neuropathy with dorsal sural conduction study, which is a new method for detection of early peripheral neuropathy, in B(12) deficiency with megaloblastic anemia. Conventional nerve conduction studies and tibial sensory-evoked potential (SEP) recording were also performed. Twenty-eight B(12)-deficient patients (15 male, 13 female, mean age 65.8 years) with megaloblastic anemia and 18 age- and sex-matched controls were included in the study. Although dorsal sural sensory nerve action potentials (SNAPs) were not recorded in 15 (54%) of 28 patients, only 9 (32%) of them were found to have polyneuropathy by conventional conduction studies. Furthermore, patients with dorsal sural SNAP had mean lower amplitude, mean longer latency, and slower velocity response when compared with controls. Twenty patients (71%) were diagnosed as having myelopathy by the combination of tibial SEP and neurological findings. Two patients whose dorsal sural SNAPs were not recorded had normal tibial SEP responses; therefore, these patients were considered to have isolated peripheral neuropathy. As a result, we conclude that dorsal sural nerve conduction study is a reliable method for detection of early peripheral neuropathy in B(12) deficiency. SN - 1085-9489 UR - https://www.unboundmedicine.com/medline/citation/16930287/Dorsal_sural_nerve_conduction_study_in_vitamin_B_12__deficiency_with_megaloblastic_anemia_ L2 - https://doi.org/10.1111/j.1529-8027.2006.00095.x DB - PRIME DP - Unbound Medicine ER -