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Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits.
Res Vet Sci. 2007 Apr; 82(2):242-5.RV

Abstract

The pharmacokinetic behaviour and bioavailability of enrofloxacin (ENR) were determined after single intravenous (iv) and intramuscular (im) administrations of 5mg/kg bw to six healthy adult Angora rabbits. Plasma ENR concentrations were measured by high performance liquid chromatography. The pharmacokinetic data were best described by a two-compartment open model. ENR pharmacokinetic parameters were similar (p>0.05) for iv and im administrations in terms of AUC0-infinity, t1/2beta and MRT. ENR was rapidly (t1/2a, 0.05 h) and almost completely (F, 87%) absorbed after im injection. In conclusion, the pharmacokinetic properties of ENR following iv and im administration in Angora rabbits are similar to other rabbit breeds, and once or twice daily iv and im administrations of ENR at the dose of 5mg/kg bw, depending upon the causative pathogen and/or severity of disorders, may be useful in treatment of infectious diseases caused by sensitive pathogens in Angora rabbits.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selcuk, 42031 Konya, Turkey. melmas@selcuk.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16930647

Citation

Elmas, Muammer, et al. "Pharmacokinetics of Enrofloxacin Following Intravenous and Intramuscular Administration in Angora Rabbits." Research in Veterinary Science, vol. 82, no. 2, 2007, pp. 242-5.
Elmas M, Uney K, Yazar E, et al. Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits. Res Vet Sci. 2007;82(2):242-5.
Elmas, M., Uney, K., Yazar, E., Karabacak, A., & Traş, B. (2007). Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits. Research in Veterinary Science, 82(2), 242-5.
Elmas M, et al. Pharmacokinetics of Enrofloxacin Following Intravenous and Intramuscular Administration in Angora Rabbits. Res Vet Sci. 2007;82(2):242-5. PubMed PMID: 16930647.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of enrofloxacin following intravenous and intramuscular administration in Angora rabbits. AU - Elmas,Muammer, AU - Uney,Kamil, AU - Yazar,Enver, AU - Karabacak,Ayse, AU - Traş,Bünyamin, Y1 - 2006/08/22/ PY - 2005/06/24/received PY - 2006/06/06/revised PY - 2006/06/26/accepted PY - 2006/8/26/pubmed PY - 2007/4/20/medline PY - 2006/8/26/entrez SP - 242 EP - 5 JF - Research in veterinary science JO - Res Vet Sci VL - 82 IS - 2 N2 - The pharmacokinetic behaviour and bioavailability of enrofloxacin (ENR) were determined after single intravenous (iv) and intramuscular (im) administrations of 5mg/kg bw to six healthy adult Angora rabbits. Plasma ENR concentrations were measured by high performance liquid chromatography. The pharmacokinetic data were best described by a two-compartment open model. ENR pharmacokinetic parameters were similar (p>0.05) for iv and im administrations in terms of AUC0-infinity, t1/2beta and MRT. ENR was rapidly (t1/2a, 0.05 h) and almost completely (F, 87%) absorbed after im injection. In conclusion, the pharmacokinetic properties of ENR following iv and im administration in Angora rabbits are similar to other rabbit breeds, and once or twice daily iv and im administrations of ENR at the dose of 5mg/kg bw, depending upon the causative pathogen and/or severity of disorders, may be useful in treatment of infectious diseases caused by sensitive pathogens in Angora rabbits. SN - 0034-5288 UR - https://www.unboundmedicine.com/medline/citation/16930647/Pharmacokinetics_of_enrofloxacin_following_intravenous_and_intramuscular_administration_in_Angora_rabbits_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(06)00126-3 DB - PRIME DP - Unbound Medicine ER -