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[Bullous amyloïdis revealing a light chains lambda myeloma].
Rev Med Interne. 2006 Sep; 27(9):694-8.RM

Abstract

INTRODUCTION

Although rare, skin lesions are regularly reported in patients with systemic amyloidosis. The existence of bullous skin lesions however is very rare; only thirty cases have been previously reported. We report a new case of bullous amyloidosis revealing a light chains lambda myeloma, and underline the usual characteristics of this type of systemic amyloidosis.

EXEGESIS

An 85-year-old man was hospitalised for a bullous eruption associated with a general asthenia. Bullous amyloidosis revealing a light chains lambda myeloma was diagnosed and confirmed by histopathological examination of a skin biopsy specimen. The patient died of a severe congestive heart failure, 15 days later, due to cardiac involvement of the amyloidosis.

CONCLUSION

Bullous amyloidosis lesions can be an early manifestation of occult dysglobulinemia. Early diagnosis would allow rapid treatment, before onset of systemic amyloidosis, which is often lethal.

Authors+Show Affiliations

Service de Dermatologie, Hôpital Robert-Debré, CHU de Reims, 51092 Reims, France. ziad.reguiai@club-internet.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Comparative Study
English Abstract
Journal Article

Language

fre

PubMed ID

16930779

Citation

Reguiaï, Z, et al. "[Bullous Amyloïdis Revealing a Light Chains Lambda Myeloma]." La Revue De Medecine Interne, vol. 27, no. 9, 2006, pp. 694-8.
Reguiaï Z, Aïnine K, Rémy-Leroux V, et al. [Bullous amyloïdis revealing a light chains lambda myeloma]. Rev Med Interne. 2006;27(9):694-8.
Reguiaï, Z., Aïnine, K., Rémy-Leroux, V., Perceau, G., Derancourt, C., & Bernard, P. (2006). [Bullous amyloïdis revealing a light chains lambda myeloma]. La Revue De Medecine Interne, 27(9), 694-8.
Reguiaï Z, et al. [Bullous Amyloïdis Revealing a Light Chains Lambda Myeloma]. Rev Med Interne. 2006;27(9):694-8. PubMed PMID: 16930779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bullous amyloïdis revealing a light chains lambda myeloma]. AU - Reguiaï,Z, AU - Aïnine,K, AU - Rémy-Leroux,V, AU - Perceau,G, AU - Derancourt,C, AU - Bernard,P, Y1 - 2006/06/16/ PY - 2006/03/07/received PY - 2006/05/19/accepted PY - 2006/8/26/pubmed PY - 2006/10/21/medline PY - 2006/8/26/entrez SP - 694 EP - 8 JF - La Revue de medecine interne JO - Rev Med Interne VL - 27 IS - 9 N2 - INTRODUCTION: Although rare, skin lesions are regularly reported in patients with systemic amyloidosis. The existence of bullous skin lesions however is very rare; only thirty cases have been previously reported. We report a new case of bullous amyloidosis revealing a light chains lambda myeloma, and underline the usual characteristics of this type of systemic amyloidosis. EXEGESIS: An 85-year-old man was hospitalised for a bullous eruption associated with a general asthenia. Bullous amyloidosis revealing a light chains lambda myeloma was diagnosed and confirmed by histopathological examination of a skin biopsy specimen. The patient died of a severe congestive heart failure, 15 days later, due to cardiac involvement of the amyloidosis. CONCLUSION: Bullous amyloidosis lesions can be an early manifestation of occult dysglobulinemia. Early diagnosis would allow rapid treatment, before onset of systemic amyloidosis, which is often lethal. SN - 0248-8663 UR - https://www.unboundmedicine.com/medline/citation/16930779/[Bullous_amyloïdis_revealing_a_light_chains_lambda_myeloma]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0248-8663(06)00237-2 DB - PRIME DP - Unbound Medicine ER -