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Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats.
J Ethnopharmacol. 2007 Jan 03; 109(1):41-7.JE

Abstract

The study was aimed to investigate the antioxidant activity of Cytisus scoparius L. (Family: Leguminosae) on CCl(4) (carbon tetrachloride) treated oxidative stress in Wistar albino rats. CCl(4) injection induced oxidative stress by a significant rise in serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) along with reduction of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-s-transferase (GST) and glutathione reductase (GRD). Pretreatment of rats with different doses of plant extract (250 and 500mg/kg) significantly lowered SGOT, SGPT, LDH and TBARS levels against CCl(4) treated rats. GSH and hepatic enzymes like SOD, CAT, GPx, GRD, and GST were significantly increased by treatment with the plant extract, against CCl(4) treated rats. The activity of extract at the dose of 500mg/kg was comparable to the standard drug, silymarin (25mg/kg). Based on these results, it was observed that Cytisus scoparius extract protects liver from oxidative stress induced by CCl(4) in rats and thus helps in evaluation of the traditional claim on this plant.

Authors+Show Affiliations

School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16930896

Citation

Raja, S, et al. "Antioxidant Effect of Cytisus Scoparius Against Carbon Tetrachloride Treated Liver Injury in Rats." Journal of Ethnopharmacology, vol. 109, no. 1, 2007, pp. 41-7.
Raja S, Ahamed KF, Kumar V, et al. Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol. 2007;109(1):41-7.
Raja, S., Ahamed, K. F., Kumar, V., Mukherjee, K., Bandyopadhyay, A., & Mukherjee, P. K. (2007). Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. Journal of Ethnopharmacology, 109(1), 41-7.
Raja S, et al. Antioxidant Effect of Cytisus Scoparius Against Carbon Tetrachloride Treated Liver Injury in Rats. J Ethnopharmacol. 2007 Jan 3;109(1):41-7. PubMed PMID: 16930896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. AU - Raja,S, AU - Ahamed,K F H Nazeer, AU - Kumar,V, AU - Mukherjee,Kakali, AU - Bandyopadhyay,A, AU - Mukherjee,Pulok K, Y1 - 2006/07/20/ PY - 2005/11/23/received PY - 2006/06/14/revised PY - 2006/06/30/accepted PY - 2006/8/26/pubmed PY - 2007/4/14/medline PY - 2006/8/26/entrez SP - 41 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 109 IS - 1 N2 - The study was aimed to investigate the antioxidant activity of Cytisus scoparius L. (Family: Leguminosae) on CCl(4) (carbon tetrachloride) treated oxidative stress in Wistar albino rats. CCl(4) injection induced oxidative stress by a significant rise in serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), lactate dehydrogenase (LDH) and thiobarbituric acid reactive substances (TBARS) along with reduction of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-s-transferase (GST) and glutathione reductase (GRD). Pretreatment of rats with different doses of plant extract (250 and 500mg/kg) significantly lowered SGOT, SGPT, LDH and TBARS levels against CCl(4) treated rats. GSH and hepatic enzymes like SOD, CAT, GPx, GRD, and GST were significantly increased by treatment with the plant extract, against CCl(4) treated rats. The activity of extract at the dose of 500mg/kg was comparable to the standard drug, silymarin (25mg/kg). Based on these results, it was observed that Cytisus scoparius extract protects liver from oxidative stress induced by CCl(4) in rats and thus helps in evaluation of the traditional claim on this plant. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16930896/Antioxidant_effect_of_Cytisus_scoparius_against_carbon_tetrachloride_treated_liver_injury_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00325-4 DB - PRIME DP - Unbound Medicine ER -