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Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research.
Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov; 75(4-5):291-7.PL

Abstract

INTRODUCTION

Perinatal depression refers to major depression in the context of pregnancy and postpartum. In consideration of its prevalence and consequences, the treatment and prevention of perinatal depression should be important public health priorities. Omega-3 fatty acids are attractive for consideration in perinatal women, due to known health benefits for the mother and baby. Antidepressant medications may pose risks in utero and in breastfeeding.

METHODS

MEDLINE and manual searches were conducted.

RESULTS

Epidemiological and preclinical data support a role of omega-3 fatty acids in perinatal depression. Two studies failed to support a role of omega-3 fatty acids for postpartum depression prophylaxis, although one included a small sample, and the other utilized a low dosage. Two pilot studies suggest good tolerability and potential efficacy in the acute treatment of perinatal depression.

CONCLUSIONS

Further research studies are warranted to determine the role of omega-3 fatty acids in the treatment of perinatal depression.

Authors+Show Affiliations

Women's Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ 85724-5002, USA. marlenef@email.arizona.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

16930971

Citation

Freeman, M P.. "Omega-3 Fatty Acids and Perinatal Depression: a Review of the Literature and Recommendations for Future Research." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 75, no. 4-5, 2006, pp. 291-7.
Freeman MP. Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. Prostaglandins Leukot Essent Fatty Acids. 2006;75(4-5):291-7.
Freeman, M. P. (2006). Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 75(4-5), 291-7.
Freeman MP. Omega-3 Fatty Acids and Perinatal Depression: a Review of the Literature and Recommendations for Future Research. Prostaglandins Leukot Essent Fatty Acids. 2006 Oct-Nov;75(4-5):291-7. PubMed PMID: 16930971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. A1 - Freeman,M P, Y1 - 2006/08/22/ PY - 2006/8/26/pubmed PY - 2007/1/12/medline PY - 2006/8/26/entrez SP - 291 EP - 7 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 75 IS - 4-5 N2 - INTRODUCTION: Perinatal depression refers to major depression in the context of pregnancy and postpartum. In consideration of its prevalence and consequences, the treatment and prevention of perinatal depression should be important public health priorities. Omega-3 fatty acids are attractive for consideration in perinatal women, due to known health benefits for the mother and baby. Antidepressant medications may pose risks in utero and in breastfeeding. METHODS: MEDLINE and manual searches were conducted. RESULTS: Epidemiological and preclinical data support a role of omega-3 fatty acids in perinatal depression. Two studies failed to support a role of omega-3 fatty acids for postpartum depression prophylaxis, although one included a small sample, and the other utilized a low dosage. Two pilot studies suggest good tolerability and potential efficacy in the acute treatment of perinatal depression. CONCLUSIONS: Further research studies are warranted to determine the role of omega-3 fatty acids in the treatment of perinatal depression. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/16930971/Omega_3_fatty_acids_and_perinatal_depression:_a_review_of_the_literature_and_recommendations_for_future_research_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(06)00121-9 DB - PRIME DP - Unbound Medicine ER -