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Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia-ischemia in the rat.
Neurobiol Learn Mem. 2007 Jan; 87(1):101-8.NL

Abstract

Environmental enrichment (EE) results in improved learning and spatial memory, as well as attenuates morphological changes resulting from cerebral ischemia in adult animals. This study examined the effects of daily EE on memory deficits in the water maze and cerebral damage, assessed in the hippocampus and cerebral cortex, caused by neonatal hypoxia-ischemia. Male Wistar rats in the 7th postnatal day were submitted to the Levine-Rice model of neonatal hypoxia-ischemia (HI), comprising permanent occlusion of the right common carotid artery and a period of hypoxia (90 min, 8%O(2)-92%N(2)). Starting two weeks after the HI event, animals were stimulated by the enriched environment (1h/day for 9 weeks); subsequent to the stimulation, performance of animals in the water maze was assessed. HI resulted in spatial reference and working memory impairments that were completely reversed by EE. Following the behavioral study, animals were killed and the hippocampal volume and cortical area were estimated. There was a significant reduction of both hippocampal volume and cortical area, ipsilateral to arterial occlusion, in HI animals; environmental stimulation had no effect on these morphological measurements. Presented data indicate that stimulation by the daily environmental enrichment recovers spatial memory deficits caused by neonatal hypoxia-ischemia without affecting tissue atrophy in either hippocampus or cortex.

Authors+Show Affiliations

Programa de Pós-graduação em Neurociências, ICBS, Universidade Federal do Rio Grande do Sul, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16931063

Citation

Pereira, Lenir Orlandi, et al. "Effects of Daily Environmental Enrichment On Memory Deficits and Brain Injury Following Neonatal Hypoxia-ischemia in the Rat." Neurobiology of Learning and Memory, vol. 87, no. 1, 2007, pp. 101-8.
Pereira LO, Arteni NS, Petersen RC, et al. Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia-ischemia in the rat. Neurobiol Learn Mem. 2007;87(1):101-8.
Pereira, L. O., Arteni, N. S., Petersen, R. C., da Rocha, A. P., Achaval, M., & Netto, C. A. (2007). Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia-ischemia in the rat. Neurobiology of Learning and Memory, 87(1), 101-8.
Pereira LO, et al. Effects of Daily Environmental Enrichment On Memory Deficits and Brain Injury Following Neonatal Hypoxia-ischemia in the Rat. Neurobiol Learn Mem. 2007;87(1):101-8. PubMed PMID: 16931063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of daily environmental enrichment on memory deficits and brain injury following neonatal hypoxia-ischemia in the rat. AU - Pereira,Lenir Orlandi, AU - Arteni,Nice Sarmento, AU - Petersen,Ruth Chamorro, AU - da Rocha,Anderson Padilha, AU - Achaval,Matilde, AU - Netto,Carlos Alexandre, Y1 - 2006/08/23/ PY - 2006/04/19/received PY - 2006/07/09/revised PY - 2006/07/10/accepted PY - 2006/8/26/pubmed PY - 2007/2/23/medline PY - 2006/8/26/entrez SP - 101 EP - 8 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 87 IS - 1 N2 - Environmental enrichment (EE) results in improved learning and spatial memory, as well as attenuates morphological changes resulting from cerebral ischemia in adult animals. This study examined the effects of daily EE on memory deficits in the water maze and cerebral damage, assessed in the hippocampus and cerebral cortex, caused by neonatal hypoxia-ischemia. Male Wistar rats in the 7th postnatal day were submitted to the Levine-Rice model of neonatal hypoxia-ischemia (HI), comprising permanent occlusion of the right common carotid artery and a period of hypoxia (90 min, 8%O(2)-92%N(2)). Starting two weeks after the HI event, animals were stimulated by the enriched environment (1h/day for 9 weeks); subsequent to the stimulation, performance of animals in the water maze was assessed. HI resulted in spatial reference and working memory impairments that were completely reversed by EE. Following the behavioral study, animals were killed and the hippocampal volume and cortical area were estimated. There was a significant reduction of both hippocampal volume and cortical area, ipsilateral to arterial occlusion, in HI animals; environmental stimulation had no effect on these morphological measurements. Presented data indicate that stimulation by the daily environmental enrichment recovers spatial memory deficits caused by neonatal hypoxia-ischemia without affecting tissue atrophy in either hippocampus or cortex. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/16931063/Effects_of_daily_environmental_enrichment_on_memory_deficits_and_brain_injury_following_neonatal_hypoxia_ischemia_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(06)00084-0 DB - PRIME DP - Unbound Medicine ER -