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Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum.
J Asian Nat Prod Res. 2006 Sep; 8(6):535-9.JA

Abstract

Two new 18-carbon norditerpenoid alkaloids, sinaconitines A (1) and B (2), together with two known alkaloids, ranaconitine (3) and lappaconitine (4), were isolated from the roots of Aconitum sinomontanum. Their structures were elucidated on the basis of spectral evidences and X-ray crystallographic analysis for 1. Furthermore, the reversed 13C NMR assignments for C-10 and C-13 of 3, 4, puberanine, puberanidine and demethyllappaconitine were revised. Compounds 1-4 were evaluated for cyclooxygenase-2 (COX-2) enzyme inhibitory activity. However, they did not show any inhibition at 10 microM.

Authors+Show Affiliations

State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 ZuChongZhi Road, Shanghai 201203, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16931429

Citation

Tan, J-J, et al. "Two New 18-carbon Norditerpenoid Alkaloids From Aconitum Sinomontanum." Journal of Asian Natural Products Research, vol. 8, no. 6, 2006, pp. 535-9.
Tan JJ, Tan CH, Ruan BQ, et al. Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum. J Asian Nat Prod Res. 2006;8(6):535-9.
Tan, J. J., Tan, C. H., Ruan, B. Q., Jiang, S. H., & Zhu, D. Y. (2006). Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum. Journal of Asian Natural Products Research, 8(6), 535-9.
Tan JJ, et al. Two New 18-carbon Norditerpenoid Alkaloids From Aconitum Sinomontanum. J Asian Nat Prod Res. 2006;8(6):535-9. PubMed PMID: 16931429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum. AU - Tan,J-J, AU - Tan,C-H, AU - Ruan,B-Q, AU - Jiang,S-H, AU - Zhu,D-Y, PY - 2006/8/26/pubmed PY - 2007/1/16/medline PY - 2006/8/26/entrez SP - 535 EP - 9 JF - Journal of Asian natural products research JO - J Asian Nat Prod Res VL - 8 IS - 6 N2 - Two new 18-carbon norditerpenoid alkaloids, sinaconitines A (1) and B (2), together with two known alkaloids, ranaconitine (3) and lappaconitine (4), were isolated from the roots of Aconitum sinomontanum. Their structures were elucidated on the basis of spectral evidences and X-ray crystallographic analysis for 1. Furthermore, the reversed 13C NMR assignments for C-10 and C-13 of 3, 4, puberanine, puberanidine and demethyllappaconitine were revised. Compounds 1-4 were evaluated for cyclooxygenase-2 (COX-2) enzyme inhibitory activity. However, they did not show any inhibition at 10 microM. SN - 1028-6020 UR - https://www.unboundmedicine.com/medline/citation/16931429/Two_new_18_carbon_norditerpenoid_alkaloids_from_Aconitum_sinomontanum_ L2 - https://www.tandfonline.com/doi/full/10.1080/10286020500175643 DB - PRIME DP - Unbound Medicine ER -