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Apo E gene polymorphism on development of diabetic nephropathy.
Cell Biochem Funct. 2007 Sep-Oct; 25(5):527-32.CB

Abstract

Type 2 diabetes causes premature morbidity and mortality due to the complications of atherosclerosis and diabetic nephropathy (DN). Polymorphism of Apo E gene is known to influence lipid metabolism. Apo E is polymorphic, consisting of three common isoforms (epsilon2, epsilon3 and epsilon4) encoded by three alleles (2, 3 and 4) in exon 4 on chromosome 19. The aim of this study was to investigate the effect of Apo E polymorphism as a prognostic risk factor for the development of DN. A total of 108 NIDDM patients were recruited from the Nephrology and Endocrinology Departments of our hospital. All subjects were divided into three groups: Group I: diabetes with nephropathy (n:37), group II: diabetes without nephropathy (n:71), group III: controls (n:46). Apo E genotypes were determined by real-time PCR. The epsilon4 allele frequency was significantly higher in-group I (10.8%) than in-group III (2.2%), (p < 0.05). In diabetics without nephropathy, the total cholesterol and LDL cholesterol levels were significantly lower in subjects with epsilon2 alleles than epsilon3 and epsilon4 alleles. In conclusion, the present prospective study indicates that the epsilon4 allele of the Apo E polymorphism is one of the prognostic risk factors involved in the development of DN with type 2 diabetes mellitus.

Authors+Show Affiliations

Department of Biochemistry, Firat University Firat Medical Center, Elazig, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16933203

Citation

Ilhan, Necip, et al. "Apo E Gene Polymorphism On Development of Diabetic Nephropathy." Cell Biochemistry and Function, vol. 25, no. 5, 2007, pp. 527-32.
Ilhan N, Kahraman N, Seçkin D, et al. Apo E gene polymorphism on development of diabetic nephropathy. Cell Biochem Funct. 2007;25(5):527-32.
Ilhan, N., Kahraman, N., Seçkin, D., Ilhan, N., & Colak, R. (2007). Apo E gene polymorphism on development of diabetic nephropathy. Cell Biochemistry and Function, 25(5), 527-32.
Ilhan N, et al. Apo E Gene Polymorphism On Development of Diabetic Nephropathy. Cell Biochem Funct. 2007 Sep-Oct;25(5):527-32. PubMed PMID: 16933203.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apo E gene polymorphism on development of diabetic nephropathy. AU - Ilhan,Necip, AU - Kahraman,Neslihan, AU - Seçkin,Dilara, AU - Ilhan,Nevin, AU - Colak,Ramis, PY - 2006/8/26/pubmed PY - 2007/11/6/medline PY - 2006/8/26/entrez SP - 527 EP - 32 JF - Cell biochemistry and function JO - Cell Biochem Funct VL - 25 IS - 5 N2 - Type 2 diabetes causes premature morbidity and mortality due to the complications of atherosclerosis and diabetic nephropathy (DN). Polymorphism of Apo E gene is known to influence lipid metabolism. Apo E is polymorphic, consisting of three common isoforms (epsilon2, epsilon3 and epsilon4) encoded by three alleles (2, 3 and 4) in exon 4 on chromosome 19. The aim of this study was to investigate the effect of Apo E polymorphism as a prognostic risk factor for the development of DN. A total of 108 NIDDM patients were recruited from the Nephrology and Endocrinology Departments of our hospital. All subjects were divided into three groups: Group I: diabetes with nephropathy (n:37), group II: diabetes without nephropathy (n:71), group III: controls (n:46). Apo E genotypes were determined by real-time PCR. The epsilon4 allele frequency was significantly higher in-group I (10.8%) than in-group III (2.2%), (p < 0.05). In diabetics without nephropathy, the total cholesterol and LDL cholesterol levels were significantly lower in subjects with epsilon2 alleles than epsilon3 and epsilon4 alleles. In conclusion, the present prospective study indicates that the epsilon4 allele of the Apo E polymorphism is one of the prognostic risk factors involved in the development of DN with type 2 diabetes mellitus. SN - 0263-6484 UR - https://www.unboundmedicine.com/medline/citation/16933203/Apo_E_gene_polymorphism_on_development_of_diabetic_nephropathy_ L2 - https://doi.org/10.1002/cbf.1348 DB - PRIME DP - Unbound Medicine ER -