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Otitis media with effusion and chronic upper respiratory tract infection in children: a randomized, placebo-controlled clinical study.
Laryngoscope. 1990 Jun; 100(6):627-33.L

Abstract

This study was performed to investigate the course of spontaneous recovery from otitis media with effusion in children with chronic rhinosinusitis treated in various ways. One hundred forty-one children between 3 and 10 years of age were selected for the presence of chronic rhinosinusitis and unilateral or bilateral otitis media with effusion. The children were assigned at random to one of four treatment groups, i.e., placebo, amoxicillin combined with xylometazoline hydrochloride nose drops, maxillary sinus drainage, or a combination of the latter two forms of therapy. The follow-up period was 6 months. Drainage of the maxillary sinus had no effect on either the recovery of the chronic upper respiratory tract infection or otitis media with effusion. Amoxicillin combined with xylometazoline nose drops had no significant effect on recovery from the upper respiratory tract infection, but did have a small but significant effect on recovery from otitis media with effusion. However, the general tendency of the upper respiratory tract and ears to recover was poor. Persistence of the chronic upper respiratory tract infection during the follow-up period proved to be a negative prognostic factor with respect to cure of otitis media with effusion. Children with chronic rhinosinusitis as defined in this study appear to have a high risk of developing chronic otitis media with effusion. The results of the study are discussed.

Authors+Show Affiliations

Department of Otorhinolaryngology-Head and Neck Surgery, Leiden University Hospital, The Netherlands.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1693411

Citation

Otten, F W., and J J. Grote. "Otitis Media With Effusion and Chronic Upper Respiratory Tract Infection in Children: a Randomized, Placebo-controlled Clinical Study." The Laryngoscope, vol. 100, no. 6, 1990, pp. 627-33.
Otten FW, Grote JJ. Otitis media with effusion and chronic upper respiratory tract infection in children: a randomized, placebo-controlled clinical study. Laryngoscope. 1990;100(6):627-33.
Otten, F. W., & Grote, J. J. (1990). Otitis media with effusion and chronic upper respiratory tract infection in children: a randomized, placebo-controlled clinical study. The Laryngoscope, 100(6), 627-33.
Otten FW, Grote JJ. Otitis Media With Effusion and Chronic Upper Respiratory Tract Infection in Children: a Randomized, Placebo-controlled Clinical Study. Laryngoscope. 1990;100(6):627-33. PubMed PMID: 1693411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Otitis media with effusion and chronic upper respiratory tract infection in children: a randomized, placebo-controlled clinical study. AU - Otten,F W, AU - Grote,J J, PY - 1990/6/1/pubmed PY - 1990/6/1/medline PY - 1990/6/1/entrez SP - 627 EP - 33 JF - The Laryngoscope JO - Laryngoscope VL - 100 IS - 6 N2 - This study was performed to investigate the course of spontaneous recovery from otitis media with effusion in children with chronic rhinosinusitis treated in various ways. One hundred forty-one children between 3 and 10 years of age were selected for the presence of chronic rhinosinusitis and unilateral or bilateral otitis media with effusion. The children were assigned at random to one of four treatment groups, i.e., placebo, amoxicillin combined with xylometazoline hydrochloride nose drops, maxillary sinus drainage, or a combination of the latter two forms of therapy. The follow-up period was 6 months. Drainage of the maxillary sinus had no effect on either the recovery of the chronic upper respiratory tract infection or otitis media with effusion. Amoxicillin combined with xylometazoline nose drops had no significant effect on recovery from the upper respiratory tract infection, but did have a small but significant effect on recovery from otitis media with effusion. However, the general tendency of the upper respiratory tract and ears to recover was poor. Persistence of the chronic upper respiratory tract infection during the follow-up period proved to be a negative prognostic factor with respect to cure of otitis media with effusion. Children with chronic rhinosinusitis as defined in this study appear to have a high risk of developing chronic otitis media with effusion. The results of the study are discussed. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/1693411/Otitis_media_with_effusion_and_chronic_upper_respiratory_tract_infection_in_children:_a_randomized_placebo_controlled_clinical_study_ L2 - https://doi.org/10.1288/00005537-199006000-00014 DB - PRIME DP - Unbound Medicine ER -