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Influence of ethanol withdrawal on fear memory: Effect of D-cycloserine.
Neuroscience. 2006 Nov 03; 142(4):979-90.N

Abstract

Animals made dependent via an ethanol (ETOH) -containing liquid diet (6% v/v) for 14 days were subjected to a contextual fear conditioning paradigm 3 days after the last consumption day. After conditioning, rats were subjected to four extinction trials by exposing the animals to the conditioned context and their freezing was evaluated for each trial. Immediately after the first extinction trial, animals were injected with D-cycloserine (DCS) 5 mg/kg i.p., a dose that did not influence the extinction in control rats. Spontaneous recovery of learned fear was tested seven days after the last extinction trial. The following day, animals were subjected to a reacquisition or a reinstatement procedure and their freezing responses evaluated 24 h later. The present study shows that: 1. discontinuation from chronic ETOH administration facilitated the formation of a new fear memory concomitant with a marked resistance to being extinguished, 2. administration of DCS (5 mg/kg) facilitated the extinction process only in ETOH withdrawn rats, 3. both reinstatement and reacquisition procedures restored the increased freezing in ETOH withdrawn animals after extinction, 4. DCS administered immediately after the first extinction trial prevented the increase in freezing following both reacquisition and reinstatement. The enhanced sensitivity to the facilitatory effect of DCS in ETOH withdrawn animals may be mediated by adaptive changes in N-methyl-D-aspartate (NMDA) receptor provoked by ETOH dependence.

Authors+Show Affiliations

Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria 5000, Córdoba, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16934411

Citation

Bertotto, M E., et al. "Influence of Ethanol Withdrawal On Fear Memory: Effect of D-cycloserine." Neuroscience, vol. 142, no. 4, 2006, pp. 979-90.
Bertotto ME, Bustos SG, Molina VA, et al. Influence of ethanol withdrawal on fear memory: Effect of D-cycloserine. Neuroscience. 2006;142(4):979-90.
Bertotto, M. E., Bustos, S. G., Molina, V. A., & Martijena, I. D. (2006). Influence of ethanol withdrawal on fear memory: Effect of D-cycloserine. Neuroscience, 142(4), 979-90.
Bertotto ME, et al. Influence of Ethanol Withdrawal On Fear Memory: Effect of D-cycloserine. Neuroscience. 2006 Nov 3;142(4):979-90. PubMed PMID: 16934411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of ethanol withdrawal on fear memory: Effect of D-cycloserine. AU - Bertotto,M E, AU - Bustos,S G, AU - Molina,V A, AU - Martijena,I D, Y1 - 2006/08/23/ PY - 2005/12/01/received PY - 2006/07/13/revised PY - 2006/07/17/accepted PY - 2006/8/29/pubmed PY - 2007/2/28/medline PY - 2006/8/29/entrez SP - 979 EP - 90 JF - Neuroscience JO - Neuroscience VL - 142 IS - 4 N2 - Animals made dependent via an ethanol (ETOH) -containing liquid diet (6% v/v) for 14 days were subjected to a contextual fear conditioning paradigm 3 days after the last consumption day. After conditioning, rats were subjected to four extinction trials by exposing the animals to the conditioned context and their freezing was evaluated for each trial. Immediately after the first extinction trial, animals were injected with D-cycloserine (DCS) 5 mg/kg i.p., a dose that did not influence the extinction in control rats. Spontaneous recovery of learned fear was tested seven days after the last extinction trial. The following day, animals were subjected to a reacquisition or a reinstatement procedure and their freezing responses evaluated 24 h later. The present study shows that: 1. discontinuation from chronic ETOH administration facilitated the formation of a new fear memory concomitant with a marked resistance to being extinguished, 2. administration of DCS (5 mg/kg) facilitated the extinction process only in ETOH withdrawn rats, 3. both reinstatement and reacquisition procedures restored the increased freezing in ETOH withdrawn animals after extinction, 4. DCS administered immediately after the first extinction trial prevented the increase in freezing following both reacquisition and reinstatement. The enhanced sensitivity to the facilitatory effect of DCS in ETOH withdrawn animals may be mediated by adaptive changes in N-methyl-D-aspartate (NMDA) receptor provoked by ETOH dependence. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/16934411/Influence_of_ethanol_withdrawal_on_fear_memory:_Effect_of_D_cycloserine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(06)00993-6 DB - PRIME DP - Unbound Medicine ER -