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Postprandial hyperglycaemia and cardiovascular complications of diabetes: an update.
Nutr Metab Cardiovasc Dis. 2006 Oct; 16(7):453-6.NM

Abstract

Type 2 diabetes is characterised by a gradual decline in insulin secretion in response to nutrient loads; hence, it is primarily a disorder of postprandial glucose (PPG) regulation. However, physicians continue to rely on fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c) levels as indicators for disease management. There is a linear relationship between the risk of cardiovascular disease (CVD) and the two-hour oral glucose tolerance test (OGTT), while a recent study confirms postprandial hyperglycaemia as an independent risk factor for CVD in type 2 diabetes. At the same time, several intervention studies have shown that treating postprandial hyperglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that postprandial hyperglycaemia may be linked to CVD through the generation of oxidative stress. Furthermore, clinical data suggest that postprandial hyperglycaemia is a common phenomenon, even in patients who may be considered in 'good metabolic control'. Therefore, in addition to HbA1c and FPG, physicians should consider monitoring and targeting PPG in patients with type 2 diabetes.

Authors+Show Affiliations

Ceriello A
Clinical Science Research Institute, Clinical Science Building, Warwick Medical School, University of Warwick, Coventry, UK. antonio.ceriello@warwick.ac.uk
Davidson J
No affiliation info available
Hanefeld M
No affiliation info available
Leiter L
No affiliation info available
Monnier L
No affiliation info available
Owens D
No affiliation info available
Tajima N
No affiliation info available
Tuomilehto J
No affiliation info available
International Prandial Glucose Regulation Study Group
No affiliation info available

MeSH

Cardiovascular DiseasesDiabetes ComplicationsDiabetes Mellitus, Type 2HumansHyperglycemiaPostprandial PeriodRisk Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16934443

Clinical Trial Links

Treating Type 2 Diabetes by Reducing Postprandial Glucose Elevations: A Paradigm Shift in Lifestyle Modification
Benefits of Continuous Glucose Monitoring With GEM Lifestyle Modification for Adults With Type 2 Diabetes

Citation

Ceriello, Antonio, et al. "Postprandial Hyperglycaemia and Cardiovascular Complications of Diabetes: an Update." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 16, no. 7, 2006, pp. 453-6.
Ceriello A, Davidson J, Hanefeld M, et al. Postprandial hyperglycaemia and cardiovascular complications of diabetes: an update. Nutr Metab Cardiovasc Dis. 2006;16(7):453-6.
Ceriello, A., Davidson, J., Hanefeld, M., Leiter, L., Monnier, L., Owens, D., Tajima, N., & Tuomilehto, J. (2006). Postprandial hyperglycaemia and cardiovascular complications of diabetes: an update. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 16(7), 453-6.
Ceriello A, et al. Postprandial Hyperglycaemia and Cardiovascular Complications of Diabetes: an Update. Nutr Metab Cardiovasc Dis. 2006;16(7):453-6. PubMed PMID: 16934443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postprandial hyperglycaemia and cardiovascular complications of diabetes: an update. AU - Ceriello,Antonio, AU - Davidson,Jamie, AU - Hanefeld,Markolf, AU - Leiter,Lawrence, AU - Monnier,Louis, AU - Owens,David, AU - Tajima,Naoko, AU - Tuomilehto,Jaakko, AU - ,, Y1 - 2006/08/24/ PY - 2006/02/20/received PY - 2006/05/07/revised PY - 2006/05/25/accepted PY - 2006/8/29/pubmed PY - 2006/10/17/medline PY - 2006/8/29/entrez SP - 453 EP - 6 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 16 IS - 7 N2 - Type 2 diabetes is characterised by a gradual decline in insulin secretion in response to nutrient loads; hence, it is primarily a disorder of postprandial glucose (PPG) regulation. However, physicians continue to rely on fasting plasma glucose (FPG) and glycosylated haemoglobin (HbA1c) levels as indicators for disease management. There is a linear relationship between the risk of cardiovascular disease (CVD) and the two-hour oral glucose tolerance test (OGTT), while a recent study confirms postprandial hyperglycaemia as an independent risk factor for CVD in type 2 diabetes. At the same time, several intervention studies have shown that treating postprandial hyperglycaemia may reduce the incidence of new cardiovascular events. Evidence supports the hypothesis that postprandial hyperglycaemia may be linked to CVD through the generation of oxidative stress. Furthermore, clinical data suggest that postprandial hyperglycaemia is a common phenomenon, even in patients who may be considered in 'good metabolic control'. Therefore, in addition to HbA1c and FPG, physicians should consider monitoring and targeting PPG in patients with type 2 diabetes. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/16934443/Postprandial_hyperglycaemia_and_cardiovascular_complications_of_diabetes:_an_update_ DB - PRIME DP - Unbound Medicine ER -