Tags

Type your tag names separated by a space and hit enter

Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs.
Eur J Pharmacol. 2006 Oct 10; 547(1-3):160-4.EJ

Abstract

We examined the effect of inhaled histamine on citric acid-induced coughs and clarified the role of ionotropic purinergic receptors in the resulting changes. Although the inhalation of 0.1 M citric acid by itself produced only a few coughs in guinea pigs, exposure to histamine, at concentrations of 0.3 to 1 mM, for 2 min concentration dependently increased the number of citric acid-induced coughs. This histamine-induced increase in the number of citric acid-induced coughs was dose dependently and significantly reduced when animals were pretreated with fexofenadine, a histamine H1 receptor antagonist. The histamine-induced increase in the number of citric acid-induced coughs was completely reduced when animals were co-pretreated with 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5-triphosphate (TNP-ATP, 50 microM), a P2X receptor antagonist, and reactive blue 2, a P2Y receptor antagonist, for 2 min. Furthermore, the ATP-induced increase in the number of citric acid-induced coughs was dose dependently and significantly decreased when animals were pretreated with fexofenadine, at doses of 0.3, 1 and 3 mg/kg, p.o. These results suggest that histamine enhances the excitability of rapidly adapting receptors to tussive stimuli via modulation of ATP release in the airways. Furthermore, ATP might act not only on P2X receptors to directly activate rapidly adapting receptors, but also on P2Y receptors to increase histamine release, indirectly increasing the cough reflex sensitivity.

Authors+Show Affiliations

Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan. kamei@hoshi.ac.jp <kamei@hoshi.ac.jp>No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16935279

Citation

Kamei, Junzo, and Yoshiki Takahashi. "Involvement of Ionotropic Purinergic Receptors in the Histamine-induced Enhancement of the Cough Reflex Sensitivity in Guinea Pigs." European Journal of Pharmacology, vol. 547, no. 1-3, 2006, pp. 160-4.
Kamei J, Takahashi Y. Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. Eur J Pharmacol. 2006;547(1-3):160-4.
Kamei, J., & Takahashi, Y. (2006). Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. European Journal of Pharmacology, 547(1-3), 160-4.
Kamei J, Takahashi Y. Involvement of Ionotropic Purinergic Receptors in the Histamine-induced Enhancement of the Cough Reflex Sensitivity in Guinea Pigs. Eur J Pharmacol. 2006 Oct 10;547(1-3):160-4. PubMed PMID: 16935279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. AU - Kamei,Junzo, AU - Takahashi,Yoshiki, Y1 - 2006/07/26/ PY - 2006/03/20/received PY - 2006/07/18/revised PY - 2006/07/19/accepted PY - 2006/8/29/pubmed PY - 2006/12/16/medline PY - 2006/8/29/entrez SP - 160 EP - 4 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 547 IS - 1-3 N2 - We examined the effect of inhaled histamine on citric acid-induced coughs and clarified the role of ionotropic purinergic receptors in the resulting changes. Although the inhalation of 0.1 M citric acid by itself produced only a few coughs in guinea pigs, exposure to histamine, at concentrations of 0.3 to 1 mM, for 2 min concentration dependently increased the number of citric acid-induced coughs. This histamine-induced increase in the number of citric acid-induced coughs was dose dependently and significantly reduced when animals were pretreated with fexofenadine, a histamine H1 receptor antagonist. The histamine-induced increase in the number of citric acid-induced coughs was completely reduced when animals were co-pretreated with 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5-triphosphate (TNP-ATP, 50 microM), a P2X receptor antagonist, and reactive blue 2, a P2Y receptor antagonist, for 2 min. Furthermore, the ATP-induced increase in the number of citric acid-induced coughs was dose dependently and significantly decreased when animals were pretreated with fexofenadine, at doses of 0.3, 1 and 3 mg/kg, p.o. These results suggest that histamine enhances the excitability of rapidly adapting receptors to tussive stimuli via modulation of ATP release in the airways. Furthermore, ATP might act not only on P2X receptors to directly activate rapidly adapting receptors, but also on P2Y receptors to increase histamine release, indirectly increasing the cough reflex sensitivity. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/16935279/Involvement_of_ionotropic_purinergic_receptors_in_the_histamine_induced_enhancement_of_the_cough_reflex_sensitivity_in_guinea_pigs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(06)00788-6 DB - PRIME DP - Unbound Medicine ER -