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Scanning laser polarimetry with variable corneal compensation in the area of apparently normal hemifield in eyes with normal-tension glaucoma.
Ophthalmology 2006; 113(11):1954-60O

Abstract

PURPOSE

To evaluate the retinal nerve fiber layer (RNFL) in the retinal segments without visual field loss in eyes with normal-tension glaucoma (NTG) that have localized visual field defects.

DESIGN

Prospective interventional case series.

PARTICIPANTS

Fifty-six Asian glaucoma patients with localized visual field defects confined to 1 hemifield and 43 normal control participants.

METHODS

A complete ophthalmic examination, the 24-2 full-threshold test on the Humphrey Field Analyzer (HFA; Carl Zeiss Meditec, Dublin, CA), and scanning laser polarimetry with variable corneal compensation (SLP-VCC; GDx-VCC, Carl Zeiss Meditec) were performed in each participant.

MAIN OUTCOME MEASURES

We compared RNFL thickness parameters on SLP-VCC printouts and severity scores based on the SLP-VCC deviation map algorithm in retinal segments with corresponding visual field defects with those in segments without visual field defects and with those in matched segments of age-matched normal controls. Linear regression analyses were performed between the RNFL thickness parameters and the severity scores in both segments with corresponding visual field defects and those without visual field defects and HFA indices (mean deviation, corrected pattern standard deviation) in these NTG eyes.

RESULTS

Seven of 56 eyes with NTG showed abnormal RNFL thickness parameters (P<0.05) in the quadrants without visual field defects, whereas no eye showed abnormal RNFL thickness parameters (P<0.05) in the matched quadrant of the control group. The mean RNFL thickness parameter in the quadrants without visual field defects in the NTG eyes was 62.41+/-7.71, which was significantly lower than in the matched quadrants of the control group (74.57+/-9.21; P<0.001) but was significantly higher than in the quadrants with corresponding visual field defects in NTG eyes (48.01+/-9.45; P<0.001). The severity score in the matched quadrants of control eyes was 0.53+/-3.20, whereas the severity score of quadrants without visual field defects of the NTG eyes was 13.52+/-35.40 (P<0.001).

CONCLUSIONS

Perimetrically normal hemifields of NTG eyes showed significantly lower RNFL thickness parameters than the corresponding retinal regions of healthy eyes, as measured by SLP-VCC. Scanning laser polarimetry with variable corneal compensation may have potential as an ancillary diagnostic tool in the evaluation of the corresponding RNFL without visual field defects in NTG eyes with localized visual field defects.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Choi J
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Republic of Korea.
    Cho HS
    No affiliation info available
    Lee CH
    No affiliation info available
    Kook MS
    No affiliation info available

    MeSH

    Adaptation, PhysiologicalAdultAgedCorneaFemaleGlaucoma, Open-AngleHumansIntraocular PressureLasersMaleMiddle AgedNerve FibersProspective StudiesRetinaSeverity of Illness IndexVisual Fields

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16935338

    Citation

    Choi, Jaewan, et al. "Scanning Laser Polarimetry With Variable Corneal Compensation in the Area of Apparently Normal Hemifield in Eyes With Normal-tension Glaucoma." Ophthalmology, vol. 113, no. 11, 2006, pp. 1954-60.
    Choi J, Cho HS, Lee CH, et al. Scanning laser polarimetry with variable corneal compensation in the area of apparently normal hemifield in eyes with normal-tension glaucoma. Ophthalmology. 2006;113(11):1954-60.
    Choi, J., Cho, H. S., Lee, C. H., & Kook, M. S. (2006). Scanning laser polarimetry with variable corneal compensation in the area of apparently normal hemifield in eyes with normal-tension glaucoma. Ophthalmology, 113(11), pp. 1954-60.
    Choi J, et al. Scanning Laser Polarimetry With Variable Corneal Compensation in the Area of Apparently Normal Hemifield in Eyes With Normal-tension Glaucoma. Ophthalmology. 2006;113(11):1954-60. PubMed PMID: 16935338.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Scanning laser polarimetry with variable corneal compensation in the area of apparently normal hemifield in eyes with normal-tension glaucoma. AU - Choi,Jaewan, AU - Cho,Hyun-soo, AU - Lee,Chang Hwan, AU - Kook,Michael S, Y1 - 2006/08/28/ PY - 2005/08/29/received PY - 2006/04/29/revised PY - 2006/05/26/accepted PY - 2006/8/29/pubmed PY - 2006/12/9/medline PY - 2006/8/29/entrez SP - 1954 EP - 60 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 11 N2 - PURPOSE: To evaluate the retinal nerve fiber layer (RNFL) in the retinal segments without visual field loss in eyes with normal-tension glaucoma (NTG) that have localized visual field defects. DESIGN: Prospective interventional case series. PARTICIPANTS: Fifty-six Asian glaucoma patients with localized visual field defects confined to 1 hemifield and 43 normal control participants. METHODS: A complete ophthalmic examination, the 24-2 full-threshold test on the Humphrey Field Analyzer (HFA; Carl Zeiss Meditec, Dublin, CA), and scanning laser polarimetry with variable corneal compensation (SLP-VCC; GDx-VCC, Carl Zeiss Meditec) were performed in each participant. MAIN OUTCOME MEASURES: We compared RNFL thickness parameters on SLP-VCC printouts and severity scores based on the SLP-VCC deviation map algorithm in retinal segments with corresponding visual field defects with those in segments without visual field defects and with those in matched segments of age-matched normal controls. Linear regression analyses were performed between the RNFL thickness parameters and the severity scores in both segments with corresponding visual field defects and those without visual field defects and HFA indices (mean deviation, corrected pattern standard deviation) in these NTG eyes. RESULTS: Seven of 56 eyes with NTG showed abnormal RNFL thickness parameters (P<0.05) in the quadrants without visual field defects, whereas no eye showed abnormal RNFL thickness parameters (P<0.05) in the matched quadrant of the control group. The mean RNFL thickness parameter in the quadrants without visual field defects in the NTG eyes was 62.41+/-7.71, which was significantly lower than in the matched quadrants of the control group (74.57+/-9.21; P<0.001) but was significantly higher than in the quadrants with corresponding visual field defects in NTG eyes (48.01+/-9.45; P<0.001). The severity score in the matched quadrants of control eyes was 0.53+/-3.20, whereas the severity score of quadrants without visual field defects of the NTG eyes was 13.52+/-35.40 (P<0.001). CONCLUSIONS: Perimetrically normal hemifields of NTG eyes showed significantly lower RNFL thickness parameters than the corresponding retinal regions of healthy eyes, as measured by SLP-VCC. Scanning laser polarimetry with variable corneal compensation may have potential as an ancillary diagnostic tool in the evaluation of the corresponding RNFL without visual field defects in NTG eyes with localized visual field defects. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16935338/Scanning_laser_polarimetry_with_variable_corneal_compensation_in_the_area_of_apparently_normal_hemifield_in_eyes_with_normal_tension_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00726-3 DB - PRIME DP - Unbound Medicine ER -