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Phencyclidine affects memory in a nitric oxide-dependent manner: working and reference memory.
Behav Brain Res. 2006 Nov 01; 174(1):49-55.BB

Abstract

Phencyclidine (PCP), a non-competitive NMDA receptor antagonist, was used to model schizophrenia-like cognitive dysfunctions of learning and memory in rats using the Morris water maze model for spatial memory. A protocol introduced by Baldi and co-workers was used to distinguish working memory from reference memory. Male Sprague-Dawley rats were administered PCP (2.0 mg/kg) before the first swimming trial on each of five spatial memory acquisition days, either alone or after pre-treatment with the nitric oxide synthase inhibitor, L-NAME (10 mg/kg). Probe tests for memory were conducted before and after each acquisition session. The results showed that PCP disrupted the acquisition of both working and reference memory. Pre-treatment with L-NAME reversed both these effects of PCP. L-NAME treatment by itself did not significantly alter either acquisition or retention of spatial memory.

Authors+Show Affiliations

Department of Pharmacology, The Sahlgrenska Academy at Göteborg University, POB 431, SE 405 30 Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16935357

Citation

Wass, Caroline, et al. "Phencyclidine Affects Memory in a Nitric Oxide-dependent Manner: Working and Reference Memory." Behavioural Brain Research, vol. 174, no. 1, 2006, pp. 49-55.
Wass C, Archer T, Pålsson E, et al. Phencyclidine affects memory in a nitric oxide-dependent manner: working and reference memory. Behav Brain Res. 2006;174(1):49-55.
Wass, C., Archer, T., Pålsson, E., Fejgin, K., Alexandersson, A., Klamer, D., Engel, J. A., & Svensson, L. (2006). Phencyclidine affects memory in a nitric oxide-dependent manner: working and reference memory. Behavioural Brain Research, 174(1), 49-55.
Wass C, et al. Phencyclidine Affects Memory in a Nitric Oxide-dependent Manner: Working and Reference Memory. Behav Brain Res. 2006 Nov 1;174(1):49-55. PubMed PMID: 16935357.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phencyclidine affects memory in a nitric oxide-dependent manner: working and reference memory. AU - Wass,Caroline, AU - Archer,Trevor, AU - Pålsson,Erik, AU - Fejgin,Kim, AU - Alexandersson,Asa, AU - Klamer,Daniel, AU - Engel,Jörgen A, AU - Svensson,Lennart, Y1 - 2006/08/28/ PY - 2006/04/06/received PY - 2006/07/04/revised PY - 2006/07/05/accepted PY - 2006/8/29/pubmed PY - 2006/12/9/medline PY - 2006/8/29/entrez SP - 49 EP - 55 JF - Behavioural brain research JO - Behav Brain Res VL - 174 IS - 1 N2 - Phencyclidine (PCP), a non-competitive NMDA receptor antagonist, was used to model schizophrenia-like cognitive dysfunctions of learning and memory in rats using the Morris water maze model for spatial memory. A protocol introduced by Baldi and co-workers was used to distinguish working memory from reference memory. Male Sprague-Dawley rats were administered PCP (2.0 mg/kg) before the first swimming trial on each of five spatial memory acquisition days, either alone or after pre-treatment with the nitric oxide synthase inhibitor, L-NAME (10 mg/kg). Probe tests for memory were conducted before and after each acquisition session. The results showed that PCP disrupted the acquisition of both working and reference memory. Pre-treatment with L-NAME reversed both these effects of PCP. L-NAME treatment by itself did not significantly alter either acquisition or retention of spatial memory. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16935357/Phencyclidine_affects_memory_in_a_nitric_oxide_dependent_manner:_working_and_reference_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(06)00378-0 DB - PRIME DP - Unbound Medicine ER -