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Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia.
Nutr Metab Cardiovasc Dis. 2006 Sep; 16(6):395-404.NM

Abstract

BACKGROUND AND AIM

Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. High intake of soy product has been suggested to prevent cardiovascular disease. The purpose of this study was to evaluate if dietary supplement of soybean D-LeciVita product, rich in polyunsaturated phospholipids (with 12% lecithin, 35% soy protein) affects serum lipids and serum and erythrocyte phospholipid fatty acid composition in type 2 diabetic patients.

METHODS AND RESULTS

Forty-seven patients (men and post-menopausal women) with isolated hypertriglyceridemia (IHTG) and combined hyperlipidemia (CHL), aged 43-70 years, were given 15g of D-LeciVita powder as a water suspension in a single evening dose during the follow-up period of 12 weeks. Patients kept their diabetic diet relatively constant. Treatment was associated with a significant (p < or = 0.001) decrease in serum total cholesterol and triglyceride levels by 12% and 22%, respectively. LDL-cholesterol decreased by 16% and HDL-cholesterol increased by 11% (p < or = 0.001). Our study shows a 27% decrease in LDL-cholesterol (p < or = 0.001) and a 12% increase in HDL-cholesterol (p < or = 0.01) in CHL type 2 diabetic patients. Triglyceride levels decreased in type 2 diabetic patients with IHTG and CHL by 29% and 13%, respectively (p < or = 0.01 and p < or = 0.05). Our results show decrease in SFA and increase in n-6 and n-3 PUFA in serum and erythrocyte phospholipids. SFA decreased and n-3 PUFA increased in serum and erythrocyte phospholipids in IHTG and CHL groups.

CONCLUSION

The present study indicated that added to a regular diet, soybean D-LeciVita product (combination of soy protein and lecithin) is associated not only with lipid-lowering effects but also with more favorable serum phospholipids fatty acid profile in type 2 diabetic patients with hyperlipidemia.

Authors+Show Affiliations

Institute for Medical Research, Laboratory for Nutrition and Metabolism, Dr Subotića 4a, Belgrade, PO Box 102, 11 129 Belgrade, Serbia and Montenegro. danijelar@imi.bg.ac.yuNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16935698

Citation

Ristić Medić, Danijela, et al. "Effects of Soybean D-LeciVita Product On Serum Lipids and Fatty Acid Composition in Type 2 Diabetic Patients With Hyperlipidemia." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 16, no. 6, 2006, pp. 395-404.
Ristić Medić D, Ristić V, Arsić A, et al. Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia. Nutr Metab Cardiovasc Dis. 2006;16(6):395-404.
Ristić Medić, D., Ristić, V., Arsić, A., Postić, M., Ristić, G., Blazencić Mladenović, V., & Tepsić, J. (2006). Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 16(6), 395-404.
Ristić Medić D, et al. Effects of Soybean D-LeciVita Product On Serum Lipids and Fatty Acid Composition in Type 2 Diabetic Patients With Hyperlipidemia. Nutr Metab Cardiovasc Dis. 2006;16(6):395-404. PubMed PMID: 16935698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of soybean D-LeciVita product on serum lipids and fatty acid composition in type 2 diabetic patients with hyperlipidemia. AU - Ristić Medić,Danijela, AU - Ristić,Vanja, AU - Arsić,Aleksandra, AU - Postić,Marija, AU - Ristić,Gordana, AU - Blazencić Mladenović,Vera, AU - Tepsić,Jasna, Y1 - 2005/11/04/ PY - 2005/02/17/received PY - 2005/06/16/revised PY - 2005/06/16/accepted PY - 2006/8/29/pubmed PY - 2006/9/23/medline PY - 2006/8/29/entrez SP - 395 EP - 404 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 16 IS - 6 N2 - BACKGROUND AND AIM: Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. High intake of soy product has been suggested to prevent cardiovascular disease. The purpose of this study was to evaluate if dietary supplement of soybean D-LeciVita product, rich in polyunsaturated phospholipids (with 12% lecithin, 35% soy protein) affects serum lipids and serum and erythrocyte phospholipid fatty acid composition in type 2 diabetic patients. METHODS AND RESULTS: Forty-seven patients (men and post-menopausal women) with isolated hypertriglyceridemia (IHTG) and combined hyperlipidemia (CHL), aged 43-70 years, were given 15g of D-LeciVita powder as a water suspension in a single evening dose during the follow-up period of 12 weeks. Patients kept their diabetic diet relatively constant. Treatment was associated with a significant (p < or = 0.001) decrease in serum total cholesterol and triglyceride levels by 12% and 22%, respectively. LDL-cholesterol decreased by 16% and HDL-cholesterol increased by 11% (p < or = 0.001). Our study shows a 27% decrease in LDL-cholesterol (p < or = 0.001) and a 12% increase in HDL-cholesterol (p < or = 0.01) in CHL type 2 diabetic patients. Triglyceride levels decreased in type 2 diabetic patients with IHTG and CHL by 29% and 13%, respectively (p < or = 0.01 and p < or = 0.05). Our results show decrease in SFA and increase in n-6 and n-3 PUFA in serum and erythrocyte phospholipids. SFA decreased and n-3 PUFA increased in serum and erythrocyte phospholipids in IHTG and CHL groups. CONCLUSION: The present study indicated that added to a regular diet, soybean D-LeciVita product (combination of soy protein and lecithin) is associated not only with lipid-lowering effects but also with more favorable serum phospholipids fatty acid profile in type 2 diabetic patients with hyperlipidemia. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/16935698/Effects_of_soybean_D_LeciVita_product_on_serum_lipids_and_fatty_acid_composition_in_type_2_diabetic_patients_with_hyperlipidemia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(05)00145-6 DB - PRIME DP - Unbound Medicine ER -