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Improved survival of persons with human immunodeficiency virus type 1 infection in the era of highly active antiretroviral therapy in Taiwan.
Jpn J Infect Dis. 2006 Aug; 59(4):222-8.JJ

Abstract

We assessed the survival of 1,044 HIV-infected persons enrolled in three periods: period 1, 1994 to 1997 (before the introduction of highly active antiretroviral therapy [HAART]); period 2, 1997 to 2000 (early-HAART); and period 3, 2000 to 2004 (late-HAART). As of 30 June 2005, 259 (24.8%) persons had died after a median observation duration of 985 days (range, 2 - 4,025 days). The mortality rate declined from 33.75 per 100 person-years in the pre-HAART era to 6.51 per 100 person-years in the late-HAART era (P < 0.0001). The adjusted hazard ratios for death in persons with a baseline CD4 count of <200 cells/mul in periods 2 and 3 were 0.605 (P = 0.007) and 0.371 (P < 0.0001), respectively, when compared with persons enrolled in period 1; the adjusted hazard ratio for death was 0.611 for persons enrolled in period 3 when compared to period 2 (P = 0.01). Our study suggested that the survival of persons in the late stage of HIV infection in Taiwan continued to improve in the late HAART era.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. hcc0401@ha.mc.ntu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16936339

Citation

Hung, Chien-Ching, et al. "Improved Survival of Persons With Human Immunodeficiency Virus Type 1 Infection in the Era of Highly Active Antiretroviral Therapy in Taiwan." Japanese Journal of Infectious Diseases, vol. 59, no. 4, 2006, pp. 222-8.
Hung CC, Hsiao CF, Chen MY, et al. Improved survival of persons with human immunodeficiency virus type 1 infection in the era of highly active antiretroviral therapy in Taiwan. Jpn J Infect Dis. 2006;59(4):222-8.
Hung, C. C., Hsiao, C. F., Chen, M. Y., Hsieh, S. M., Chang, S. Y., Sheng, W. H., Sun, H. Y., & Chang, S. C. (2006). Improved survival of persons with human immunodeficiency virus type 1 infection in the era of highly active antiretroviral therapy in Taiwan. Japanese Journal of Infectious Diseases, 59(4), 222-8.
Hung CC, et al. Improved Survival of Persons With Human Immunodeficiency Virus Type 1 Infection in the Era of Highly Active Antiretroviral Therapy in Taiwan. Jpn J Infect Dis. 2006;59(4):222-8. PubMed PMID: 16936339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improved survival of persons with human immunodeficiency virus type 1 infection in the era of highly active antiretroviral therapy in Taiwan. AU - Hung,Chien-Ching, AU - Hsiao,Chin-Fu, AU - Chen,Mao-Yuan, AU - Hsieh,Szu-Min, AU - Chang,Sui-Yuan, AU - Sheng,Wang-Huei, AU - Sun,Hsin-Yun, AU - Chang,Shan-Chwen, PY - 2006/8/29/pubmed PY - 2006/10/13/medline PY - 2006/8/29/entrez SP - 222 EP - 8 JF - Japanese journal of infectious diseases JO - Jpn J Infect Dis VL - 59 IS - 4 N2 - We assessed the survival of 1,044 HIV-infected persons enrolled in three periods: period 1, 1994 to 1997 (before the introduction of highly active antiretroviral therapy [HAART]); period 2, 1997 to 2000 (early-HAART); and period 3, 2000 to 2004 (late-HAART). As of 30 June 2005, 259 (24.8%) persons had died after a median observation duration of 985 days (range, 2 - 4,025 days). The mortality rate declined from 33.75 per 100 person-years in the pre-HAART era to 6.51 per 100 person-years in the late-HAART era (P < 0.0001). The adjusted hazard ratios for death in persons with a baseline CD4 count of <200 cells/mul in periods 2 and 3 were 0.605 (P = 0.007) and 0.371 (P < 0.0001), respectively, when compared with persons enrolled in period 1; the adjusted hazard ratio for death was 0.611 for persons enrolled in period 3 when compared to period 2 (P = 0.01). Our study suggested that the survival of persons in the late stage of HIV infection in Taiwan continued to improve in the late HAART era. SN - 1344-6304 UR - https://www.unboundmedicine.com/medline/citation/16936339/Improved_survival_of_persons_with_human_immunodeficiency_virus_type_1_infection_in_the_era_of_highly_active_antiretroviral_therapy_in_Taiwan_ L2 - http://hivinsite.ucsf.edu/InSite?page=kb-03-03-05 DB - PRIME DP - Unbound Medicine ER -