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The effect of platelet-activating factor on histamine release from rat peritoneal mast cells.
Jpn J Pharmacol. 1990 May; 53(1):75-80.JJ

Abstract

The effect of platelet-activating factor (PAF) on histamine release from peritoneal mast cells of adult and young male rats was investigated. PAF alone tended to release histamine from the mast cells of adult and young rats, although very slightly. On the other hand, PAF significantly inhibited the histamine release induced by the Ca2+ ionophore A23187 in mast cells obtained from rats of either age group, but not that by compound 48/80. Such inhibition was not seen with lyso-PAF. CV-3988, a PAF antagonist, antagonized the inhibitory effect of PAF on the A23187-induced histamine release in mast cells from adult and young rats. These results suggest that PAF does not have a strong histamine-liberating action on mast cells, and that PAF inhibits the calcium influx into mast cells through the activation of PAF receptors.

Authors+Show Affiliations

Misawa M
Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Huang SC
No affiliation info available

MeSH

AgingAnimalsAscitic FluidBuffersCalcimycinCalciumHistamine ReleaseIn Vitro TechniquesMaleMast CellsPhospholipid EthersPlatelet Activating FactorRatsRats, Inbred Strainsp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1693706

Citation

Misawa, M, and S C. Huang. "The Effect of Platelet-activating Factor On Histamine Release From Rat Peritoneal Mast Cells." Japanese Journal of Pharmacology, vol. 53, no. 1, 1990, pp. 75-80.
Misawa M, Huang SC. The effect of platelet-activating factor on histamine release from rat peritoneal mast cells. Jpn J Pharmacol. 1990;53(1):75-80.
Misawa, M., & Huang, S. C. (1990). The effect of platelet-activating factor on histamine release from rat peritoneal mast cells. Japanese Journal of Pharmacology, 53(1), 75-80.
Misawa M, Huang SC. The Effect of Platelet-activating Factor On Histamine Release From Rat Peritoneal Mast Cells. Jpn J Pharmacol. 1990;53(1):75-80. PubMed PMID: 1693706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of platelet-activating factor on histamine release from rat peritoneal mast cells. AU - Misawa,M, AU - Huang,S C, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez SP - 75 EP - 80 JF - Japanese journal of pharmacology JO - Jpn J Pharmacol VL - 53 IS - 1 N2 - The effect of platelet-activating factor (PAF) on histamine release from peritoneal mast cells of adult and young male rats was investigated. PAF alone tended to release histamine from the mast cells of adult and young rats, although very slightly. On the other hand, PAF significantly inhibited the histamine release induced by the Ca2+ ionophore A23187 in mast cells obtained from rats of either age group, but not that by compound 48/80. Such inhibition was not seen with lyso-PAF. CV-3988, a PAF antagonist, antagonized the inhibitory effect of PAF on the A23187-induced histamine release in mast cells from adult and young rats. These results suggest that PAF does not have a strong histamine-liberating action on mast cells, and that PAF inhibits the calcium influx into mast cells through the activation of PAF receptors. SN - 0021-5198 UR - https://www.unboundmedicine.com/medline/citation/1693706/The_effect_of_platelet_activating_factor_on_histamine_release_from_rat_peritoneal_mast_cells_ DB - PRIME DP - Unbound Medicine ER -