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Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis.
Turk J Gastroenterol 2006; 17(3):172-6TJ

Abstract

BACKGROUND/AIMS

Serum pepsinogen levels are considered as a non-endoscopic blood test in the diagnosis of atrophic gastritis. The objective of the present study was to investigate whether there is any difference between pepsinogen levels in Helicobacter pylori-positive and -negative patients with atrophic gastritis, and to analyze the relationship between histopathology and pepsinogen levels after treatment in H. pylori-positive patients with atrophic gastritis.

METHODS

The study enrolled a total of 30 cases with atrophic gastritis (18 H. pylori-positive and 12 H. pylori-negative). The H. pylori-positive cases received a one-week eradication treatment. Initially for all and after the treatment for H. pylori-positive cases, serum pepsinogen I and II levels, anti-H. pylori IgG titration and histopathologic analysis were carried out.

RESULTS

In the H. pylori-positive patients with atrophic gastritis, the levels of pepsinogen I and pepsinogen I/II ratio were lower while the levels of pepsinogen II were higher compared to the H. pylori-negative patients (p<0.05 for all). The post-treatment serum pepsinogen I levels and pepsinogen I/II ratios did not change in the H. pylori-positive group, while the levels of pepsinogen II, H. pylori antibody titration and gastric atrophy degree remarkably decreased (p<0.05 for all).

CONCLUSIONS

In atrophic gastritis, the levels of serum pepsinogen and pepsinogen I/II ratio show a difference in H. pylori-negative versus -positive cases. Additionally, the usage of pepsinogen II as a serum marker in predicting the eradication of H. pylori with atrophic gastritis could be more reliable than pepsinogen I or the I/II ratio.

Authors+Show Affiliations

Department of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, Harran University, Sanliurfa, and Department of Gastroenterology, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey. drcengizbolukbas@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16941249

Citation

Bölükbaş, Cengiz, et al. "Relationship Between Helicobacter Pylori Status and Serum Pepsinogens as Serologic Markers in Atrophic Gastritis." The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, vol. 17, no. 3, 2006, pp. 172-6.
Bölükbaş C, Bölükbaş FF, Ovünç O, et al. Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis. Turk J Gastroenterol. 2006;17(3):172-6.
Bölükbaş, C., Bölükbaş, F. F., Ovünç, O., Kiliç, G., Dalay, R., Güven, H., ... Pişkinpaşa, N. (2006). Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis. The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology, 17(3), pp. 172-6.
Bölükbaş C, et al. Relationship Between Helicobacter Pylori Status and Serum Pepsinogens as Serologic Markers in Atrophic Gastritis. Turk J Gastroenterol. 2006;17(3):172-6. PubMed PMID: 16941249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis. AU - Bölükbaş,Cengiz, AU - Bölükbaş,Füsun F, AU - Ovünç,Oya, AU - Kiliç,Güray, AU - Dalay,Remzi, AU - Güven,Hatice, AU - Uras,Fikriye, AU - Yardimci,Turay K, AU - Sökmen,Mehmet H, AU - Agan,Ahmet F, AU - Pişkinpaşa,Nezih, PY - 2006/8/31/pubmed PY - 2007/8/19/medline PY - 2006/8/31/entrez SP - 172 EP - 6 JF - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JO - Turk J Gastroenterol VL - 17 IS - 3 N2 - BACKGROUND/AIMS: Serum pepsinogen levels are considered as a non-endoscopic blood test in the diagnosis of atrophic gastritis. The objective of the present study was to investigate whether there is any difference between pepsinogen levels in Helicobacter pylori-positive and -negative patients with atrophic gastritis, and to analyze the relationship between histopathology and pepsinogen levels after treatment in H. pylori-positive patients with atrophic gastritis. METHODS: The study enrolled a total of 30 cases with atrophic gastritis (18 H. pylori-positive and 12 H. pylori-negative). The H. pylori-positive cases received a one-week eradication treatment. Initially for all and after the treatment for H. pylori-positive cases, serum pepsinogen I and II levels, anti-H. pylori IgG titration and histopathologic analysis were carried out. RESULTS: In the H. pylori-positive patients with atrophic gastritis, the levels of pepsinogen I and pepsinogen I/II ratio were lower while the levels of pepsinogen II were higher compared to the H. pylori-negative patients (p<0.05 for all). The post-treatment serum pepsinogen I levels and pepsinogen I/II ratios did not change in the H. pylori-positive group, while the levels of pepsinogen II, H. pylori antibody titration and gastric atrophy degree remarkably decreased (p<0.05 for all). CONCLUSIONS: In atrophic gastritis, the levels of serum pepsinogen and pepsinogen I/II ratio show a difference in H. pylori-negative versus -positive cases. Additionally, the usage of pepsinogen II as a serum marker in predicting the eradication of H. pylori with atrophic gastritis could be more reliable than pepsinogen I or the I/II ratio. SN - 1300-4948 UR - https://www.unboundmedicine.com/medline/citation/16941249/Relationship_between_Helicobacter_pylori_status_and_serum_pepsinogens_as_serologic_markers_in_atrophic_gastritis_ L2 - http://www.turkjgastroenterol.org/eng/makale/3613/240/Full-Text DB - PRIME DP - Unbound Medicine ER -