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Are men with low selenium levels at increased risk of prostate cancer?
Eur J Cancer 2006; 42(15):2463-71EJ

Abstract

A meta-analysis was undertaken to quantitatively determine if men with low selenium levels were at increased risk of prostate cancer. PubMed, EMBASE and current contents were searched to identify relevant studies. The effect size was calculated by pooling the mean difference for serum, plasma and toenail selenium levels (95% confidence intervals) separately and combined using a random effects model. Meta-regression analysis explored possible sources of heterogeneity. Twenty epidemiologic studies were selected. Mean differences were: -5.55 microg/l (-9.82; -1.27; p=0.01), -0.01 microg/g (-0.03; 0.006; p=0.19), -0.52 microg/l (-4.63; 3.58; p=0.80) for serum, toenail and plasma studies, respectively. Overall, the pooled standardized mean difference between cases and controls was; -0.23 (-0.40; -0.05; p=0.01) indicating a possible inverse association between selenium levels and risk of prostate cancer. Differences in selenium levels between populations, a possible threshold effect and the relationship between selenium and the different stages of prostate cancer require further investigation.

Authors+Show Affiliations

Department of General Practice, Katholieke Universiteit Leuven, Kapucijnenvoer 33, Blok J, 3000 Leuven, Belgium. brinkman@skynet.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

16945521

Citation

Brinkman, Maree, et al. "Are Men With Low Selenium Levels at Increased Risk of Prostate Cancer?" European Journal of Cancer (Oxford, England : 1990), vol. 42, no. 15, 2006, pp. 2463-71.
Brinkman M, Reulen RC, Kellen E, et al. Are men with low selenium levels at increased risk of prostate cancer? Eur J Cancer. 2006;42(15):2463-71.
Brinkman, M., Reulen, R. C., Kellen, E., Buntinx, F., & Zeegers, M. P. (2006). Are men with low selenium levels at increased risk of prostate cancer? European Journal of Cancer (Oxford, England : 1990), 42(15), pp. 2463-71.
Brinkman M, et al. Are Men With Low Selenium Levels at Increased Risk of Prostate Cancer. Eur J Cancer. 2006;42(15):2463-71. PubMed PMID: 16945521.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Are men with low selenium levels at increased risk of prostate cancer? AU - Brinkman,Maree, AU - Reulen,Raoul C, AU - Kellen,Eliane, AU - Buntinx,Frank, AU - Zeegers,Maurice P, Y1 - 2006/09/01/ PY - 2006/02/17/received PY - 2006/02/26/revised PY - 2006/02/28/accepted PY - 2006/9/2/pubmed PY - 2006/12/19/medline PY - 2006/9/2/entrez SP - 2463 EP - 71 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 42 IS - 15 N2 - A meta-analysis was undertaken to quantitatively determine if men with low selenium levels were at increased risk of prostate cancer. PubMed, EMBASE and current contents were searched to identify relevant studies. The effect size was calculated by pooling the mean difference for serum, plasma and toenail selenium levels (95% confidence intervals) separately and combined using a random effects model. Meta-regression analysis explored possible sources of heterogeneity. Twenty epidemiologic studies were selected. Mean differences were: -5.55 microg/l (-9.82; -1.27; p=0.01), -0.01 microg/g (-0.03; 0.006; p=0.19), -0.52 microg/l (-4.63; 3.58; p=0.80) for serum, toenail and plasma studies, respectively. Overall, the pooled standardized mean difference between cases and controls was; -0.23 (-0.40; -0.05; p=0.01) indicating a possible inverse association between selenium levels and risk of prostate cancer. Differences in selenium levels between populations, a possible threshold effect and the relationship between selenium and the different stages of prostate cancer require further investigation. SN - 0959-8049 UR - https://www.unboundmedicine.com/medline/citation/16945521/Are_men_with_low_selenium_levels_at_increased_risk_of_prostate_cancer L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(06)00576-4 DB - PRIME DP - Unbound Medicine ER -