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Fruit and vegetable consumption and risk of cholecystectomy in women.

Abstract

PURPOSE

Many constituents of fruits and vegetables may reduce the risk for gallstones, but prospective data relating fruit and vegetable intake to gallstone disease are sparse.

METHODS

We prospectively studied fruit and vegetable consumption in relation to the risk of cholecystectomy in a cohort of 77,090 women in the Nurses' Health Study, 37 to 64 years of age, who had no history of gallstone disease. Women reported on follow-up questionnaires both their consumption of fruits and vegetables and whether they had undergone cholecystectomy.

RESULTS

During 1,060,033 person-years of follow-up from 1984 to 2000, participants reported 6608 cases of cholecystectomy. After adjusting for established or suspected risk factors, the relative risk for women in the highest quintile of overall consumption of fruits and vegetables was 0.79 (95% confidence interval [CI], 0.73-0.87, P for trend<.0001) compared with those in the lowest quintile. Similar results were seen for both total fruits and total vegetables separately. The composite items of fruits and vegetables including green leafy vegetables, citrus fruits, vitamin C-rich fruits and vegetables, and cruciferous vegetables also were each inversely associated with the risk.

CONCLUSIONS

Our findings suggest a protective role of greater fruit and vegetable consumption against risk of cholecystectomy in women.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536-0298, USA. hpcjt@channing.harvard.edu

    , ,

    Source

    The American journal of medicine 119:9 2006 Sep pg 760-7

    MeSH

    Adult
    Cholecystectomy
    Diet
    Female
    Fruit
    Gallstones
    Humans
    Middle Aged
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    16945611

    Citation

    Tsai, Chung-Jyi, et al. "Fruit and Vegetable Consumption and Risk of Cholecystectomy in Women." The American Journal of Medicine, vol. 119, no. 9, 2006, pp. 760-7.
    Tsai CJ, Leitzmann MF, Willett WC, et al. Fruit and vegetable consumption and risk of cholecystectomy in women. Am J Med. 2006;119(9):760-7.
    Tsai, C. J., Leitzmann, M. F., Willett, W. C., & Giovannucci, E. L. (2006). Fruit and vegetable consumption and risk of cholecystectomy in women. The American Journal of Medicine, 119(9), pp. 760-7.
    Tsai CJ, et al. Fruit and Vegetable Consumption and Risk of Cholecystectomy in Women. Am J Med. 2006;119(9):760-7. PubMed PMID: 16945611.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Fruit and vegetable consumption and risk of cholecystectomy in women. AU - Tsai,Chung-Jyi, AU - Leitzmann,Michael F, AU - Willett,Walter C, AU - Giovannucci,Edward L, PY - 2005/10/27/received PY - 2006/02/20/revised PY - 2006/02/24/accepted PY - 2006/9/2/pubmed PY - 2006/9/15/medline PY - 2006/9/2/entrez SP - 760 EP - 7 JF - The American journal of medicine JO - Am. J. Med. VL - 119 IS - 9 N2 - PURPOSE: Many constituents of fruits and vegetables may reduce the risk for gallstones, but prospective data relating fruit and vegetable intake to gallstone disease are sparse. METHODS: We prospectively studied fruit and vegetable consumption in relation to the risk of cholecystectomy in a cohort of 77,090 women in the Nurses' Health Study, 37 to 64 years of age, who had no history of gallstone disease. Women reported on follow-up questionnaires both their consumption of fruits and vegetables and whether they had undergone cholecystectomy. RESULTS: During 1,060,033 person-years of follow-up from 1984 to 2000, participants reported 6608 cases of cholecystectomy. After adjusting for established or suspected risk factors, the relative risk for women in the highest quintile of overall consumption of fruits and vegetables was 0.79 (95% confidence interval [CI], 0.73-0.87, P for trend<.0001) compared with those in the lowest quintile. Similar results were seen for both total fruits and total vegetables separately. The composite items of fruits and vegetables including green leafy vegetables, citrus fruits, vitamin C-rich fruits and vegetables, and cruciferous vegetables also were each inversely associated with the risk. CONCLUSIONS: Our findings suggest a protective role of greater fruit and vegetable consumption against risk of cholecystectomy in women. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/16945611/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9343(06)00340-8 DB - PRIME DP - Unbound Medicine ER -