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The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats.
Psychopharmacology (Berl). 2006 Nov; 188(4):641-9.P

Abstract

RATIONALE

Previous studies demonstrated that pharmacological blockade of CB1 cannabinoid receptors decreases the extinction of conditioned fear and spatial memory in rodents. However, the effects of CB1 cannabinoid receptor activation in this response remain unclear.

OBJECTIVES

To evaluate the effects of the cannabinoid agonist WIN 55,212-2 (WIN) and the cannabinoid antagonist SR 147778 (SR) on the extinction of contextual fear memory in rats 24 h or 30 days after fear conditioning.

METHODS

For fear conditioning, rats were placed in the conditioning chamber for 3 min and received a 1-s electric foot shock (1.5 mA). Retrieval testing consisted of a 3-min exposure to the conditioning chamber and extinction training consisted of successive 9-min exposures at 24-h intervals. Rats were also evaluated in the open field and water maze reversal task.

RESULTS

The administration of SR (1.0 mg/kg, i.p.) and WIN (0.25 mg/kg, i.p.) before extinction training disrupted and facilitated, respectively, the extinction of 24 h contextual fear memory. These effects were not related to any disturbance in memory retrieval, unconditioned freezing expression, or locomotor activity. WIN (0.25 mg/kg, i.p.) also facilitated the extinction of 30-day-old contextual fear memory, while the prior administration of SR (0.2 mg/kg, i.p.) antagonized this response. The facilitative effect of WIN on memory extinction does not seem to be specific for contextual fear memory because it was also observed in the water maze reversal task.

CONCLUSIONS

These results suggest cannabinoid receptor agonists as potential drugs to treat anxiety disorders related to the retrieval of aversive memories.

Authors+Show Affiliations

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário Trindade, Florianópolis, Santa Catarina, 88049-900, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16947018

Citation

Pamplona, Fabrício A., et al. "The Cannabinoid Receptor Agonist WIN 55,212-2 Facilitates the Extinction of Contextual Fear Memory and Spatial Memory in Rats." Psychopharmacology, vol. 188, no. 4, 2006, pp. 641-9.
Pamplona FA, Prediger RD, Pandolfo P, et al. The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats. Psychopharmacology (Berl). 2006;188(4):641-9.
Pamplona, F. A., Prediger, R. D., Pandolfo, P., & Takahashi, R. N. (2006). The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats. Psychopharmacology, 188(4), 641-9.
Pamplona FA, et al. The Cannabinoid Receptor Agonist WIN 55,212-2 Facilitates the Extinction of Contextual Fear Memory and Spatial Memory in Rats. Psychopharmacology (Berl). 2006;188(4):641-9. PubMed PMID: 16947018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cannabinoid receptor agonist WIN 55,212-2 facilitates the extinction of contextual fear memory and spatial memory in rats. AU - Pamplona,Fabrício A, AU - Prediger,Rui D S, AU - Pandolfo,Pablo, AU - Takahashi,Reinaldo N, Y1 - 2006/09/01/ PY - 2006/01/25/received PY - 2006/06/28/accepted PY - 2006/9/2/pubmed PY - 2007/3/14/medline PY - 2006/9/2/entrez SP - 641 EP - 9 JF - Psychopharmacology JO - Psychopharmacology (Berl.) VL - 188 IS - 4 N2 - RATIONALE: Previous studies demonstrated that pharmacological blockade of CB1 cannabinoid receptors decreases the extinction of conditioned fear and spatial memory in rodents. However, the effects of CB1 cannabinoid receptor activation in this response remain unclear. OBJECTIVES: To evaluate the effects of the cannabinoid agonist WIN 55,212-2 (WIN) and the cannabinoid antagonist SR 147778 (SR) on the extinction of contextual fear memory in rats 24 h or 30 days after fear conditioning. METHODS: For fear conditioning, rats were placed in the conditioning chamber for 3 min and received a 1-s electric foot shock (1.5 mA). Retrieval testing consisted of a 3-min exposure to the conditioning chamber and extinction training consisted of successive 9-min exposures at 24-h intervals. Rats were also evaluated in the open field and water maze reversal task. RESULTS: The administration of SR (1.0 mg/kg, i.p.) and WIN (0.25 mg/kg, i.p.) before extinction training disrupted and facilitated, respectively, the extinction of 24 h contextual fear memory. These effects were not related to any disturbance in memory retrieval, unconditioned freezing expression, or locomotor activity. WIN (0.25 mg/kg, i.p.) also facilitated the extinction of 30-day-old contextual fear memory, while the prior administration of SR (0.2 mg/kg, i.p.) antagonized this response. The facilitative effect of WIN on memory extinction does not seem to be specific for contextual fear memory because it was also observed in the water maze reversal task. CONCLUSIONS: These results suggest cannabinoid receptor agonists as potential drugs to treat anxiety disorders related to the retrieval of aversive memories. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/16947018/The_cannabinoid_receptor_agonist_WIN_55212_2_facilitates_the_extinction_of_contextual_fear_memory_and_spatial_memory_in_rats_ L2 - https://dx.doi.org/10.1007/s00213-006-0514-0 DB - PRIME DP - Unbound Medicine ER -