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Effects of combination of melatonin and dexamethasone on acute lung injury in a mice model of carrageenan-induced pleurisy.
J Pineal Res. 2006 Oct; 41(3):228-37.JP

Abstract

The aim of this study was to investigate the effects of combination therapy with melatonin and dexamethasone (DEX) on acute lung injury. In particular, we investigated the effects of combination therapy in animal models of acute lung inflammation (carrageenan-induced pleurisy). Injection of carrageenan into the pleural cavity of rats elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils [polymorphonuclear leukocyte (PMN)] as well as an infiltration of PMN in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), and prostaglandin E2 (PGE2). Furthermore, carrageenan induced an upregulation of the adhesion molecules ICAM-1 and P-selectin, inducible nitric oxide synthase, cycloxygenase-2 as well as nitrotyrosine as determined by immunohistochemical analysis of lung tissues. No anti-inflammatory effect was observed in animals treated with melatonin (10 mg/kg) or with DEX (0.01 mg/kg) alone. This study shows that the combination therapy with melatonin and DEX reduced the degree of acute lung inflammation and tissue damage associated with carrageenan-induced pleurisy in mice and supports the possible use of melatonin in combination with steroids in order to reduce the dose and the side effects related with the use of steroids for the management of inflammatory disease.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Messina, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16948783

Citation

Crisafulli, Concetta, et al. "Effects of Combination of Melatonin and Dexamethasone On Acute Lung Injury in a Mice Model of Carrageenan-induced Pleurisy." Journal of Pineal Research, vol. 41, no. 3, 2006, pp. 228-37.
Crisafulli C, Mazzon E, Muià C, et al. Effects of combination of melatonin and dexamethasone on acute lung injury in a mice model of carrageenan-induced pleurisy. J Pineal Res. 2006;41(3):228-37.
Crisafulli, C., Mazzon, E., Muià, C., Bella, P., Esposito, E., Meli, R., & Cuzzocrea, S. (2006). Effects of combination of melatonin and dexamethasone on acute lung injury in a mice model of carrageenan-induced pleurisy. Journal of Pineal Research, 41(3), 228-37.
Crisafulli C, et al. Effects of Combination of Melatonin and Dexamethasone On Acute Lung Injury in a Mice Model of Carrageenan-induced Pleurisy. J Pineal Res. 2006;41(3):228-37. PubMed PMID: 16948783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of combination of melatonin and dexamethasone on acute lung injury in a mice model of carrageenan-induced pleurisy. AU - Crisafulli,Concetta, AU - Mazzon,Emanuela, AU - Muià,Carmelo, AU - Bella,PaoloDi, AU - Esposito,Emanuela, AU - Meli,Rosaria, AU - Cuzzocrea,Salvatore, PY - 2006/9/5/pubmed PY - 2006/12/23/medline PY - 2006/9/5/entrez SP - 228 EP - 37 JF - Journal of pineal research JO - J Pineal Res VL - 41 IS - 3 N2 - The aim of this study was to investigate the effects of combination therapy with melatonin and dexamethasone (DEX) on acute lung injury. In particular, we investigated the effects of combination therapy in animal models of acute lung inflammation (carrageenan-induced pleurisy). Injection of carrageenan into the pleural cavity of rats elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity which contained a large number of neutrophils [polymorphonuclear leukocyte (PMN)] as well as an infiltration of PMN in lung tissues and subsequent lipid peroxidation, and increased production of nitrite/nitrate (NOx), and prostaglandin E2 (PGE2). Furthermore, carrageenan induced an upregulation of the adhesion molecules ICAM-1 and P-selectin, inducible nitric oxide synthase, cycloxygenase-2 as well as nitrotyrosine as determined by immunohistochemical analysis of lung tissues. No anti-inflammatory effect was observed in animals treated with melatonin (10 mg/kg) or with DEX (0.01 mg/kg) alone. This study shows that the combination therapy with melatonin and DEX reduced the degree of acute lung inflammation and tissue damage associated with carrageenan-induced pleurisy in mice and supports the possible use of melatonin in combination with steroids in order to reduce the dose and the side effects related with the use of steroids for the management of inflammatory disease. SN - 0742-3098 UR - https://www.unboundmedicine.com/medline/citation/16948783/Effects_of_combination_of_melatonin_and_dexamethasone_on_acute_lung_injury_in_a_mice_model_of_carrageenan_induced_pleurisy_ L2 - https://doi.org/10.1111/j.1600-079X.2006.00358.x DB - PRIME DP - Unbound Medicine ER -