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Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study.
J Psychiatr Res. 2007 Oct; 41(8):625-34.JP

Abstract

Involvement of the prefrontal cortex in schizophrenia has been implicated by neuropsychological, as well as neuropathological and imaging studies. Reductions of N-acetylaspartate (NAA), an in vivo marker of neuronal integrity, have repeatedly been detected in the frontal lobes of patients with schizophrenia by proton magnetic resonance spectroscopy (1H-MRS). In chronic medicated patients, a positive correlation between NAA levels of the prefrontal cortex and cognitive functioning has been observed, but to date, there have been no studies in first-episode neuroleptic-naive patients. In this study, single-voxel 1H-MRS was used to investigate neuronal function of the dorsolateral prefrontal cortex in 15 first-episode and 20 chronic schizophrenic patients. Outcomes were compared to 20 age-matched healthy controls to assess the relationship between prefrontal metabolism and neuropsychological performance. Patients with chronic schizophrenia had significant reductions of NAA, glutamate/glutamine, and choline levels compared to first-episode patients and healthy controls. Furthermore, creatine and phosphocreatine were significantly reduced in both patient groups compared to healthy controls. In the neuropsychological tests, chronic schizophrenic patients performed significantly poorer in the Auditory Verbal Learning Task (AVLT) compared to first-episode patients. In both patient groups, NAA levels of the left frontal lobe significantly correlated with performances in verbal learning and memory. These results corroborate data from recent structural and spectroscopic imaging studies of the frontal lobes in schizophrenia, in which cortical gray matter reductions after onset of symptoms as well as reduced levels of NAA in chronic, but not in first-episode schizophrenic patients have been reported.

Authors+Show Affiliations

Department of Psychiatry, University of Muenster, Albert-Schweitzer Strasse 11, D-48149 Muenster, NRW, Germany. ohrmann@uni-muenster.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16949099

Citation

Ohrmann, Patricia, et al. "Cognitive Impairment and in Vivo Metabolites in First-episode Neuroleptic-naive and Chronic Medicated Schizophrenic Patients: a Proton Magnetic Resonance Spectroscopy Study." Journal of Psychiatric Research, vol. 41, no. 8, 2007, pp. 625-34.
Ohrmann P, Siegmund A, Suslow T, et al. Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study. J Psychiatr Res. 2007;41(8):625-34.
Ohrmann, P., Siegmund, A., Suslow, T., Pedersen, A., Spitzberg, K., Kersting, A., Rothermundt, M., Arolt, V., Heindel, W., & Pfleiderer, B. (2007). Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study. Journal of Psychiatric Research, 41(8), 625-34.
Ohrmann P, et al. Cognitive Impairment and in Vivo Metabolites in First-episode Neuroleptic-naive and Chronic Medicated Schizophrenic Patients: a Proton Magnetic Resonance Spectroscopy Study. J Psychiatr Res. 2007;41(8):625-34. PubMed PMID: 16949099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study. AU - Ohrmann,Patricia, AU - Siegmund,Ansgar, AU - Suslow,Thomas, AU - Pedersen,Anya, AU - Spitzberg,Katharina, AU - Kersting,Anette, AU - Rothermundt,Matthias, AU - Arolt,Volker, AU - Heindel,Walter, AU - Pfleiderer,Bettina, Y1 - 2006/09/01/ PY - 2006/05/03/received PY - 2006/07/04/revised PY - 2006/07/05/accepted PY - 2006/9/5/pubmed PY - 2007/7/17/medline PY - 2006/9/5/entrez SP - 625 EP - 34 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 41 IS - 8 N2 - Involvement of the prefrontal cortex in schizophrenia has been implicated by neuropsychological, as well as neuropathological and imaging studies. Reductions of N-acetylaspartate (NAA), an in vivo marker of neuronal integrity, have repeatedly been detected in the frontal lobes of patients with schizophrenia by proton magnetic resonance spectroscopy (1H-MRS). In chronic medicated patients, a positive correlation between NAA levels of the prefrontal cortex and cognitive functioning has been observed, but to date, there have been no studies in first-episode neuroleptic-naive patients. In this study, single-voxel 1H-MRS was used to investigate neuronal function of the dorsolateral prefrontal cortex in 15 first-episode and 20 chronic schizophrenic patients. Outcomes were compared to 20 age-matched healthy controls to assess the relationship between prefrontal metabolism and neuropsychological performance. Patients with chronic schizophrenia had significant reductions of NAA, glutamate/glutamine, and choline levels compared to first-episode patients and healthy controls. Furthermore, creatine and phosphocreatine were significantly reduced in both patient groups compared to healthy controls. In the neuropsychological tests, chronic schizophrenic patients performed significantly poorer in the Auditory Verbal Learning Task (AVLT) compared to first-episode patients. In both patient groups, NAA levels of the left frontal lobe significantly correlated with performances in verbal learning and memory. These results corroborate data from recent structural and spectroscopic imaging studies of the frontal lobes in schizophrenia, in which cortical gray matter reductions after onset of symptoms as well as reduced levels of NAA in chronic, but not in first-episode schizophrenic patients have been reported. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/16949099/Cognitive_impairment_and_in_vivo_metabolites_in_first_episode_neuroleptic_naive_and_chronic_medicated_schizophrenic_patients:_a_proton_magnetic_resonance_spectroscopy_study_ DB - PRIME DP - Unbound Medicine ER -