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The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test.
Clin Nutr. 2007 Feb; 26(1):57-62.CN

Abstract

BACKGROUND & AIMS

Systemic chemotherapy may damage gastrointestinal epithelium. Mucositis is associated with increased intestinal permeability (IP). It is known that IP test with chromium 51-ethylene diaminetetra-acetate (51Cr-EDTA) is a useful tool to assess the mucositis. Oral glutamine supplements (OGS) may have a role in the prevention of chemotherapy-induced mucositis/stomatitis. The aim of this study was to characterize the relationship between the urinary excretion of 51Cr-EDTA and the severity of mucositis, and the effect of OGS on 5-fluorouracil/leucovorin (FU/LV)-induced mucositis/stomatitis.

METHODS

Fifty-one patients with advanced or metastatic cancer received FU/LV chemotherapy. The control group included 18 healthy volunteers. IP was assessed via the measurement of 51Cr-EDTA urinary excretion after oral challenge, on days 7 after the discontinuation of chemotherapy. Of the 51 patients, 22 patients received OGS (30 g/day) and 29 received only best supportive care (BSC). Glutamine supplementation continued for 15 days. It was initiated at least 3 days before the beginning of chemotherapy. Mucositis/stomatitis was graded according to version 3.0 of the Common Terminology Criteria for Adverse Events.

RESULTS

In the chemotherapy group, the median (25 percentile, 75 percentile) IP test score was significantly higher than those of the control group [6.78% (4.63, 10.66) vs. 2.17% (1.38, 2.40), P<0.001]. The severity of stomatitis was significantly correlated with IP test scores (r=0.898, P<0.001). In the OGS group, the median IP test score was significantly lower than that of the BSC group [4.69% (3.10, 6.48) vs. 8.54% (6.48, 15.31), P<0.001]. A mucositis/stomatitis of grade 2-4 was observed in two patients of the OGS group (9%), and in 11 patients (38%) in the BSC group (P<0.001).

CONCLUSIONS

The IP test may be a useful tool in the evaluation of mucositis/stomatitis. OGS may exert a protective effect on FU/LV-induced mucositis/stomatitis. Further studies, however, will be necessary to define the role of glutamine supplementation in FU/LV-induced mucositis/stomatitis.

Authors+Show Affiliations

Choi K
Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Republic of Korea.
Lee SS
No affiliation info available
Oh SJ
No affiliation info available
Lim SY
No affiliation info available
Lim SY
No affiliation info available
Jeon WK
No affiliation info available
Oh TY
No affiliation info available
Kim JW
No affiliation info available

MeSH

AdultAgedAntimetabolites, AntineoplasticAntineoplastic Combined Chemotherapy ProtocolsChromium RadioisotopesEdetic AcidFemaleFluorouracilGlutamineHumansIntestinal AbsorptionLeucovorinMaleMiddle AgedMucositisNeoplasmsPermeabilitySeverity of Illness IndexStomatitisTreatment Outcome

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16949180

Clinical Trial Links

Effects of Oral L-Glutamine in Head and Neck Cancer Patients During Radiotherapy

Citation

Choi, Kwon, et al. "The Effect of Oral Glutamine On 5-fluorouracil/leucovorin-induced Mucositis/stomatitis Assessed By Intestinal Permeability Test." Clinical Nutrition (Edinburgh, Scotland), vol. 26, no. 1, 2007, pp. 57-62.
Choi K, Lee SS, Oh SJ, et al. The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. Clin Nutr. 2007;26(1):57-62.
Choi, K., Lee, S. S., Oh, S. J., Lim, S. Y., Lim, S. Y., Jeon, W. K., Oh, T. Y., & Kim, J. W. (2007). The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. Clinical Nutrition (Edinburgh, Scotland), 26(1), 57-62.
Choi K, et al. The Effect of Oral Glutamine On 5-fluorouracil/leucovorin-induced Mucositis/stomatitis Assessed By Intestinal Permeability Test. Clin Nutr. 2007;26(1):57-62. PubMed PMID: 16949180.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test. AU - Choi,Kwon, AU - Lee,Seung Sei, AU - Oh,Suk Joong, AU - Lim,Seong Yong, AU - Lim,Si Young, AU - Jeon,Woo Kyu, AU - Oh,Tae Yun, AU - Kim,Jeong Wook, Y1 - 2006/09/01/ PY - 2006/01/06/received PY - 2006/05/23/revised PY - 2006/07/04/accepted PY - 2006/9/5/pubmed PY - 2007/5/1/medline PY - 2006/9/5/entrez SP - 57 EP - 62 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 26 IS - 1 N2 - BACKGROUND & AIMS: Systemic chemotherapy may damage gastrointestinal epithelium. Mucositis is associated with increased intestinal permeability (IP). It is known that IP test with chromium 51-ethylene diaminetetra-acetate (51Cr-EDTA) is a useful tool to assess the mucositis. Oral glutamine supplements (OGS) may have a role in the prevention of chemotherapy-induced mucositis/stomatitis. The aim of this study was to characterize the relationship between the urinary excretion of 51Cr-EDTA and the severity of mucositis, and the effect of OGS on 5-fluorouracil/leucovorin (FU/LV)-induced mucositis/stomatitis. METHODS: Fifty-one patients with advanced or metastatic cancer received FU/LV chemotherapy. The control group included 18 healthy volunteers. IP was assessed via the measurement of 51Cr-EDTA urinary excretion after oral challenge, on days 7 after the discontinuation of chemotherapy. Of the 51 patients, 22 patients received OGS (30 g/day) and 29 received only best supportive care (BSC). Glutamine supplementation continued for 15 days. It was initiated at least 3 days before the beginning of chemotherapy. Mucositis/stomatitis was graded according to version 3.0 of the Common Terminology Criteria for Adverse Events. RESULTS: In the chemotherapy group, the median (25 percentile, 75 percentile) IP test score was significantly higher than those of the control group [6.78% (4.63, 10.66) vs. 2.17% (1.38, 2.40), P<0.001]. The severity of stomatitis was significantly correlated with IP test scores (r=0.898, P<0.001). In the OGS group, the median IP test score was significantly lower than that of the BSC group [4.69% (3.10, 6.48) vs. 8.54% (6.48, 15.31), P<0.001]. A mucositis/stomatitis of grade 2-4 was observed in two patients of the OGS group (9%), and in 11 patients (38%) in the BSC group (P<0.001). CONCLUSIONS: The IP test may be a useful tool in the evaluation of mucositis/stomatitis. OGS may exert a protective effect on FU/LV-induced mucositis/stomatitis. Further studies, however, will be necessary to define the role of glutamine supplementation in FU/LV-induced mucositis/stomatitis. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/16949180/The_effect_of_oral_glutamine_on_5_fluorouracil/leucovorin_induced_mucositis/stomatitis_assessed_by_intestinal_permeability_test_ DB - PRIME DP - Unbound Medicine ER -