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Paraoxonase gene polymorphism, serum lipid, and oxidized low-density lipoprotein in preeclampsia.
Eur J Obstet Gynecol Reprod Biol. 2007 Jul; 133(1):47-52.EJ

Abstract

OBJECTIVES

Human paraoxonase-1 (PON-1) is thought to play a role in preeclampsia and atherosclerosis, mainly through a reduction in low-density lipoprotein oxidation. Oxidized low-density lipoprotein (LDL) is very important in endothelial dysfunction of preeclampsia. The aim of the present study was to investigate the association between PON1 gene polymorphism and preeclampsia and to determine concentrations of serum lipid in preeclampsia patients. We aimed also to evaluate serum oxidized LDL levels in normal and preeclampsia patients.

STUDY DESIGN

We performed the present study in 57 control women and 32 preeclampsia patients. PON-1 genotypes were determined by polymerase chain reaction amplification and restriction fragment length polymorphism. Serum triglyceride, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were measured. We also measured serum levels of oxidized LDL by ELISA method.

RESULTS

There was no significant difference in PON1 genotype frequencies between the control and preeclampsia patients. The levels of serum cholesterol and high-density lipoprotein were significantly lower in preeclampsia patients compared with that of the control women (p=0.05, and p<0.01, respectively). The serum levels of oxidized LDL in preeclampsia patients were significantly higher than those in the control women (p=0.001).

CONCLUSIONS

These findings support the importance of the atherogenic lipid profile and oxidized LDL that is enhanced in preeclampsia, and these findings may be significant contributors to endothelial dysfunction.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Ewha Womans University, Seoul, Republic of Korea. kkyj@ewha.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16949193

Citation

Kim, Young Ju, et al. "Paraoxonase Gene Polymorphism, Serum Lipid, and Oxidized Low-density Lipoprotein in Preeclampsia." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 133, no. 1, 2007, pp. 47-52.
Kim YJ, Park H, Lee HY, et al. Paraoxonase gene polymorphism, serum lipid, and oxidized low-density lipoprotein in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2007;133(1):47-52.
Kim, Y. J., Park, H., Lee, H. Y., Ahn, Y. M., Ha, E. H., Suh, S. H., & Pang, M. G. (2007). Paraoxonase gene polymorphism, serum lipid, and oxidized low-density lipoprotein in preeclampsia. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 133(1), 47-52.
Kim YJ, et al. Paraoxonase Gene Polymorphism, Serum Lipid, and Oxidized Low-density Lipoprotein in Preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2007;133(1):47-52. PubMed PMID: 16949193.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Paraoxonase gene polymorphism, serum lipid, and oxidized low-density lipoprotein in preeclampsia. AU - Kim,Young Ju, AU - Park,Hyesook, AU - Lee,Hwa Young, AU - Ahn,Young-mo, AU - Ha,Eun Hee, AU - Suh,Suk Hyo, AU - Pang,Myung-Geol, Y1 - 2006/09/01/ PY - 2006/03/16/received PY - 2006/07/05/revised PY - 2006/07/19/accepted PY - 2006/9/5/pubmed PY - 2007/9/6/medline PY - 2006/9/5/entrez SP - 47 EP - 52 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 133 IS - 1 N2 - OBJECTIVES: Human paraoxonase-1 (PON-1) is thought to play a role in preeclampsia and atherosclerosis, mainly through a reduction in low-density lipoprotein oxidation. Oxidized low-density lipoprotein (LDL) is very important in endothelial dysfunction of preeclampsia. The aim of the present study was to investigate the association between PON1 gene polymorphism and preeclampsia and to determine concentrations of serum lipid in preeclampsia patients. We aimed also to evaluate serum oxidized LDL levels in normal and preeclampsia patients. STUDY DESIGN: We performed the present study in 57 control women and 32 preeclampsia patients. PON-1 genotypes were determined by polymerase chain reaction amplification and restriction fragment length polymorphism. Serum triglyceride, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were measured. We also measured serum levels of oxidized LDL by ELISA method. RESULTS: There was no significant difference in PON1 genotype frequencies between the control and preeclampsia patients. The levels of serum cholesterol and high-density lipoprotein were significantly lower in preeclampsia patients compared with that of the control women (p=0.05, and p<0.01, respectively). The serum levels of oxidized LDL in preeclampsia patients were significantly higher than those in the control women (p=0.001). CONCLUSIONS: These findings support the importance of the atherogenic lipid profile and oxidized LDL that is enhanced in preeclampsia, and these findings may be significant contributors to endothelial dysfunction. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/16949193/Paraoxonase_gene_polymorphism_serum_lipid_and_oxidized_low_density_lipoprotein_in_preeclampsia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(06)00465-9 DB - PRIME DP - Unbound Medicine ER -