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The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons.
Neuroscience. 2006 Nov 17; 143(1):265-72.N

Abstract

Cannabinoid receptor agonists have been demonstrated to inhibit medullary and spinal cord dorsal horn nociceptive neurons. The effect of cannabinoids on thermoreceptive specific neurons in the spinal or medullary dorsal horn remains unknown. In the present study, single-unit recordings from the rat medullary dorsal horn were performed to examine the effect of a cannabinoid receptor agonists on cold-specific lamina I spinothalamic tract neurons. The cannabinoid CB1/CB2 receptor agonist, WIN 55,212-2 (WIN-2), was locally applied to the medullary dorsal horn and the neuronal activity evoked by cooling the receptive field was recorded. WIN-2 (1 microg/microl and 2 microg/microl) significantly attenuated cold-evoked activity. Co-administration of the CB1 receptor antagonist SR 141716 with WIN-2 did not affect cold-evoked activity. These results demonstrate a potential mechanism by which cannabinoids produce hypothermia, and also suggest that cannabinoids may affect non-noxious thermal discrimination.

Authors+Show Affiliations

Department of Physiology, College of Osteopathic Medicine, University of New England, Biddeford, ME 04005, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16949215

Citation

Ogawa, A, and I D. Meng. "The Cannabinoid Receptor Agonist, WIN 55,212-2, Inhibits Cool-specific Lamina I Medullary Dorsal Horn Neurons." Neuroscience, vol. 143, no. 1, 2006, pp. 265-72.
Ogawa A, Meng ID. The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons. Neuroscience. 2006;143(1):265-72.
Ogawa, A., & Meng, I. D. (2006). The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons. Neuroscience, 143(1), 265-72.
Ogawa A, Meng ID. The Cannabinoid Receptor Agonist, WIN 55,212-2, Inhibits Cool-specific Lamina I Medullary Dorsal Horn Neurons. Neuroscience. 2006 Nov 17;143(1):265-72. PubMed PMID: 16949215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cannabinoid receptor agonist, WIN 55,212-2, inhibits cool-specific lamina I medullary dorsal horn neurons. AU - Ogawa,A, AU - Meng,I D, Y1 - 2006/09/01/ PY - 2006/05/02/received PY - 2006/07/27/revised PY - 2006/07/27/accepted PY - 2006/9/5/pubmed PY - 2007/1/27/medline PY - 2006/9/5/entrez SP - 265 EP - 72 JF - Neuroscience JO - Neuroscience VL - 143 IS - 1 N2 - Cannabinoid receptor agonists have been demonstrated to inhibit medullary and spinal cord dorsal horn nociceptive neurons. The effect of cannabinoids on thermoreceptive specific neurons in the spinal or medullary dorsal horn remains unknown. In the present study, single-unit recordings from the rat medullary dorsal horn were performed to examine the effect of a cannabinoid receptor agonists on cold-specific lamina I spinothalamic tract neurons. The cannabinoid CB1/CB2 receptor agonist, WIN 55,212-2 (WIN-2), was locally applied to the medullary dorsal horn and the neuronal activity evoked by cooling the receptive field was recorded. WIN-2 (1 microg/microl and 2 microg/microl) significantly attenuated cold-evoked activity. Co-administration of the CB1 receptor antagonist SR 141716 with WIN-2 did not affect cold-evoked activity. These results demonstrate a potential mechanism by which cannabinoids produce hypothermia, and also suggest that cannabinoids may affect non-noxious thermal discrimination. SN - 0306-4522 UR - https://www.unboundmedicine.com/medline/citation/16949215/The_cannabinoid_receptor_agonist_WIN_55212_2_inhibits_cool_specific_lamina_I_medullary_dorsal_horn_neurons_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4522(06)01054-2 DB - PRIME DP - Unbound Medicine ER -