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Stability of cosmetic formulations containing esters of vitamins E and A: chemical and physical aspects.
Int J Pharm. 2006 Dec 11; 327(1-2):12-6.IJ

Abstract

Cosmetic stability prediction relies on quantitative chemical determinations of active components after certain times and in different temperatures. However, physical stability, an important parameter in skin care products is not considered in these conditions. This study proposes the determination of cosmetic stability chemical and physical parameters validated by (HPLC) chromatography and rheological measurements, respectively, using a gel-cream containing retinyl palmitate and tocopheryl acetate as a model system. The predicted shelf life addresses both the physical and chemical aspects of the system. Results emphasize the importance of studying both parameters by showing the relation of components degradation and physical stability. Moreover, they contribute to an improved understanding of physical and chemical stability aspects of cosmetic formulations, mainly if they contain Vitamins A and E derivatives.

Authors+Show Affiliations

Laboratory of Cosmetic Technology, Department of Pharmaceutical Sciences, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, Bairro Monte Alegre, 14040-903 Ribeirão Preto, SP, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16949224

Citation

Guaratini, Thais, et al. "Stability of Cosmetic Formulations Containing Esters of Vitamins E and A: Chemical and Physical Aspects." International Journal of Pharmaceutics, vol. 327, no. 1-2, 2006, pp. 12-6.
Guaratini T, Gianeti MD, Campos PM. Stability of cosmetic formulations containing esters of vitamins E and A: chemical and physical aspects. Int J Pharm. 2006;327(1-2):12-6.
Guaratini, T., Gianeti, M. D., & Campos, P. M. (2006). Stability of cosmetic formulations containing esters of vitamins E and A: chemical and physical aspects. International Journal of Pharmaceutics, 327(1-2), 12-6.
Guaratini T, Gianeti MD, Campos PM. Stability of Cosmetic Formulations Containing Esters of Vitamins E and A: Chemical and Physical Aspects. Int J Pharm. 2006 Dec 11;327(1-2):12-6. PubMed PMID: 16949224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of cosmetic formulations containing esters of vitamins E and A: chemical and physical aspects. AU - Guaratini,Thais, AU - Gianeti,Mirela D, AU - Campos,Patrícia M B G M, Y1 - 2006/07/15/ PY - 2005/12/14/received PY - 2006/07/10/revised PY - 2006/07/11/accepted PY - 2006/9/5/pubmed PY - 2007/3/14/medline PY - 2006/9/5/entrez SP - 12 EP - 6 JF - International journal of pharmaceutics JO - Int J Pharm VL - 327 IS - 1-2 N2 - Cosmetic stability prediction relies on quantitative chemical determinations of active components after certain times and in different temperatures. However, physical stability, an important parameter in skin care products is not considered in these conditions. This study proposes the determination of cosmetic stability chemical and physical parameters validated by (HPLC) chromatography and rheological measurements, respectively, using a gel-cream containing retinyl palmitate and tocopheryl acetate as a model system. The predicted shelf life addresses both the physical and chemical aspects of the system. Results emphasize the importance of studying both parameters by showing the relation of components degradation and physical stability. Moreover, they contribute to an improved understanding of physical and chemical stability aspects of cosmetic formulations, mainly if they contain Vitamins A and E derivatives. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/16949224/Stability_of_cosmetic_formulations_containing_esters_of_vitamins_E_and_A:_chemical_and_physical_aspects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(06)00587-4 DB - PRIME DP - Unbound Medicine ER -