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Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet.
J Ethnopharmacol. 2007 Jan 19; 109(2):207-13.JE

Abstract

The present study was designed to explore the possible antioxidant and hypolipidemic effects of the aqueous extract of Ajuga iva (0.5% in the diet) in rats fed a high-cholesterol (1%) diet (HCD). The results indicated that the HCD-Ai versus HCD treatment led to many changes in biochemical parameters. They showed a decrease of plasma total cholesterol (TC) and VLDL-cholesterol but an increase of HDL(2)-cholesterol. The triacylglycerol contents were reduced in plasma and in VLDL. The lipid peroxidation determined by TBARS was decreased by 75% in plasma. TBARS in liver, heart and kidneys were highly reduced excepted in the adipose tissue. Ajuga iva treatment enhanced superoxide dismutase activity in liver and kidney. Glutathione reductase activity was lowered in adipose tissue but increased in liver and in kidney. A significant increase was noted in glutathione peroxidase activity in liver, heart and kidney but a low value in adipose tissue was observed. In conclusion, the present study demonstrates that in addition to its potent TG and TC-lowering effects, Ajuga iva is effective in improving the antioxidant status by reducing lipid peroxidation in plasma and tissues and enhancing the antioxidant enzymes in rats fed high-cholesterol diet. Furthermore, Ajuga iva may reduce intestinal cholesterol absorption.

Authors+Show Affiliations

Laboratoire de Nutrition Clinique et Métabolique, Faculté des Sciences, Université d'Oran Es Sénia, 31000 Oran, Algeria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16949233

Citation

Chenni, A, et al. "Effect of Aqueous Extract of Ajuga Iva Supplementation On Plasma Lipid Profile and Tissue Antioxidant Status in Rats Fed a High-cholesterol Diet." Journal of Ethnopharmacology, vol. 109, no. 2, 2007, pp. 207-13.
Chenni A, Yahia DA, Boukortt FO, et al. Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet. J Ethnopharmacol. 2007;109(2):207-13.
Chenni, A., Yahia, D. A., Boukortt, F. O., Prost, J., Lacaille-Dubois, M. A., & Bouchenak, M. (2007). Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet. Journal of Ethnopharmacology, 109(2), 207-13.
Chenni A, et al. Effect of Aqueous Extract of Ajuga Iva Supplementation On Plasma Lipid Profile and Tissue Antioxidant Status in Rats Fed a High-cholesterol Diet. J Ethnopharmacol. 2007 Jan 19;109(2):207-13. PubMed PMID: 16949233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet. AU - Chenni,A, AU - Yahia,D Ait, AU - Boukortt,F O, AU - Prost,J, AU - Lacaille-Dubois,M A, AU - Bouchenak,M, Y1 - 2006/07/25/ PY - 2006/03/13/received PY - 2006/05/23/revised PY - 2006/05/25/accepted PY - 2006/9/5/pubmed PY - 2007/4/6/medline PY - 2006/9/5/entrez SP - 207 EP - 13 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 109 IS - 2 N2 - The present study was designed to explore the possible antioxidant and hypolipidemic effects of the aqueous extract of Ajuga iva (0.5% in the diet) in rats fed a high-cholesterol (1%) diet (HCD). The results indicated that the HCD-Ai versus HCD treatment led to many changes in biochemical parameters. They showed a decrease of plasma total cholesterol (TC) and VLDL-cholesterol but an increase of HDL(2)-cholesterol. The triacylglycerol contents were reduced in plasma and in VLDL. The lipid peroxidation determined by TBARS was decreased by 75% in plasma. TBARS in liver, heart and kidneys were highly reduced excepted in the adipose tissue. Ajuga iva treatment enhanced superoxide dismutase activity in liver and kidney. Glutathione reductase activity was lowered in adipose tissue but increased in liver and in kidney. A significant increase was noted in glutathione peroxidase activity in liver, heart and kidney but a low value in adipose tissue was observed. In conclusion, the present study demonstrates that in addition to its potent TG and TC-lowering effects, Ajuga iva is effective in improving the antioxidant status by reducing lipid peroxidation in plasma and tissues and enhancing the antioxidant enzymes in rats fed high-cholesterol diet. Furthermore, Ajuga iva may reduce intestinal cholesterol absorption. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16949233/Effect_of_aqueous_extract_of_Ajuga_iva_supplementation_on_plasma_lipid_profile_and_tissue_antioxidant_status_in_rats_fed_a_high_cholesterol_diet_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(06)00358-8 DB - PRIME DP - Unbound Medicine ER -