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Treatment of drug-induced psychosis in Parkinson's disease with ziprasidone can induce severe dose-dependent off-periods and pathological laughing.
Clin Neurol Neurosurg. 2007 Feb; 109(2):188-91.CN

Abstract

"Atypical anti-psychotics" are substances of choice in treating drug-induced psychosis (DP) in Parkinson's disease (PD). We report on four patients with DP who received treatment with ziprasidone after previously applied clozapine and quetiapine had failed. Three patients showed a significant improvement of DP, without deterioration of motor function. In one case, ziprasidone considerably increased decline in off-periods. Two patients developed pathological laughing as a possible side-effect of ziprasidone. Ziprasidone may serve as an additional "atypical anti-psychotic" for the treatment of DP in PD but can also induce deterioration of motor function.

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Authors+Show Affiliations

Schindehütte J
Paracelsus Elena-Klinik Kassel, Klinikstrasse 16, 34128 Kassel, Germany. jschind@gwdg.de
Trenkwalder C
No affiliation info available

MeSH

AgedAntiparkinson AgentsAntipsychotic AgentsClozapineDibenzothiazepinesDose-Response Relationship, DrugDrug Therapy, CombinationHumansLaughterLevodopaMaleMiddle AgedNeurologic ExaminationParkinson DiseaseParkinson Disease, SecondaryPiperazinesPsychoses, Substance-InducedQuetiapine FumarateThiazoles

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16949733

Citation

Schindehütte, Jan, and Claudia Trenkwalder. "Treatment of Drug-induced Psychosis in Parkinson's Disease With Ziprasidone Can Induce Severe Dose-dependent Off-periods and Pathological Laughing." Clinical Neurology and Neurosurgery, vol. 109, no. 2, 2007, pp. 188-91.
Schindehütte J, Trenkwalder C. Treatment of drug-induced psychosis in Parkinson's disease with ziprasidone can induce severe dose-dependent off-periods and pathological laughing. Clin Neurol Neurosurg. 2007;109(2):188-91.
Schindehütte, J., & Trenkwalder, C. (2007). Treatment of drug-induced psychosis in Parkinson's disease with ziprasidone can induce severe dose-dependent off-periods and pathological laughing. Clinical Neurology and Neurosurgery, 109(2), 188-91.
Schindehütte J, Trenkwalder C. Treatment of Drug-induced Psychosis in Parkinson's Disease With Ziprasidone Can Induce Severe Dose-dependent Off-periods and Pathological Laughing. Clin Neurol Neurosurg. 2007;109(2):188-91. PubMed PMID: 16949733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of drug-induced psychosis in Parkinson's disease with ziprasidone can induce severe dose-dependent off-periods and pathological laughing. AU - Schindehütte,Jan, AU - Trenkwalder,Claudia, Y1 - 2006/09/01/ PY - 2006/01/19/received PY - 2006/04/30/revised PY - 2006/07/21/accepted PY - 2006/9/5/pubmed PY - 2007/4/4/medline PY - 2006/9/5/entrez SP - 188 EP - 91 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 109 IS - 2 N2 - "Atypical anti-psychotics" are substances of choice in treating drug-induced psychosis (DP) in Parkinson's disease (PD). We report on four patients with DP who received treatment with ziprasidone after previously applied clozapine and quetiapine had failed. Three patients showed a significant improvement of DP, without deterioration of motor function. In one case, ziprasidone considerably increased decline in off-periods. Two patients developed pathological laughing as a possible side-effect of ziprasidone. Ziprasidone may serve as an additional "atypical anti-psychotic" for the treatment of DP in PD but can also induce deterioration of motor function. SN - 0303-8467 UR - https://www.unboundmedicine.com/medline/citation/16949733/Treatment_of_drug_induced_psychosis_in_Parkinson's_disease_with_ziprasidone_can_induce_severe_dose_dependent_off_periods_and_pathological_laughing_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(06)00115-6 DB - PRIME DP - Unbound Medicine ER -